Open Access DOI:10.23937/2643-4059/1710017
Efficacy and Tolerability of Quetiapine Extended Release (XR) as Monotherapy in the Treatment of Major Depressive Disorder
Ozden Arisoy, MD, Michelle Murphy, MD, Edwin Meresh, MD and Angelos Halaris, MD, PhD
Article Type: Research Article | First Published: November 25, 2019
The aim of this study was to confirm the efficacy and tolerability of Quetiapine XR as monotherapy in the treatment of Major Depressive Disorder (MDD) and determine the optimal dosing regimen to maximize efficacy and reduce non-compliance due to side effects. This was a 12-week study with MDD subjects. The primary outcome measure was the Hamilton Rating Scale for Depression (HAMD) total score comparing baseline to end of treatment at week 12. Other assessments included the Hamilton Rating Scale ...
Open Access DOI:10.23937/2643-4059/1710016
Review of the Effect of Religion on Anxiety
William C Stewart, MD, Megan J Wetselaar, BA, Lindsay A Nelson, BS and Jeanette A Stewart, RN
Article Type: Review Article | First Published: November 04, 2019
Very little information is available about the influence of religion upon anxiety. The objective of this article is to review the medical literature regarding the influence of personal religious belief and religious-based activities on anxiety. Studies were reviewed evaluating anxiety and the effect of religion in peer reviewed medical literature by using search terms in PubMed and Cochrane data bases. There were 32 studies included. This review showed, in almost every study, that religion in ge...
Open Access DOI:10.23937/2643-4059/1710014
The Effect of Music Therapy on Cognitive Functions and Adaptation in Alzheimer's Patients
Busra Kayaaslan and Neslihan Lok
Article Type: Review Article | First Published: August 23, 2019
With the increasing life expectancy in the world, chronic diseases are seen in elderly individuals. There is currently no treatment that can prevent, stop or cure Alzheimer’s disease, one of these chronic diseases, or slow down neurodegeneration in AD. The treatments used are symptomatic treatments to slow down the course of the disease. Since the 1960s, psychosocial interventions have been used in addition to medications in the treatment of AD and its use has increased after the 2000s. One of...
Open Access DOI:10.23937/2643-4059/1710013
Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression
Frank Adu-Nti, George Ghartey-Kwansah and Benjamin Aboagye
Article Type: Review Article | First Published: July 19, 2019
Major depressive disorder (MDD) is the most common psychiatric disease and it affects millions of people across the world. Patients suffering from MDD consistently complain about cognitive disturbances, significantly worsening the burden of this illness. The second most frequent mental illness in Europe is mood disorders and they are dominated by MDD, affecting 7% of the population. The recent discovery that the N-methyl-D-aspartate receptor (NMDAR) antagonist; ketamine; a revolutionary novel a...
