Open Access DOI:10.23937/2377-3634/1410029
Alpha- and Beta-Cell Proliferation and Extracellular Signaling - A Hypothesis
Cyril J Craven
Article Type: Review Article | First Published: April 01, 2015
A model is offered towards an understanding of the cellular communications of two major cell types of the pancreas. The beta and alpha cells of the pancreas are considered to be coupled by the insulin and glucagon hormones that they produce, respectively. In this model, insulin stimulates the alpha cells to release glucagon and grow, especially by cell division, while glucagon similarly stimulates the beta cells to release insulin and grow....
Open Access DOI:10.23937/2377-3634/1410027
Effect of Diabetes Mellitus on Metabolic Biomarker Levels in Patients with End Stage Renal Disease or Undergoing Total Joint Arthroplasty
J. Saluk, Bansal V, Banos A, Hopkinson W, Rees H, Syed D, Hoppensteadt D, Abro S and Iqbal O and Fareed J
Article Type: Research Article | First Published: March 28, 2015
Diabetes mellitus (DM) is a proven risk factor for diseases such as end stage renal disease (ESRD) and osteoarthritis (OA). Thus, it is not unreasonable to assume that some of the ESRD/ OA pathogenesis, namely inflammation and metabolic dysfunction, could be attributed to DM as a comorbitity. This study aims to investigate DM's effect on metabolic biomarker levels in patients with ESRD or undergoing total joint arthroplasty....
Open Access DOI:10.23937/2377-3634/1410026
Trends in the Occurrence of Type 2 Diabetes in Community-Dwelling Trinidadian Subjects, 1993-2014
Koreen Peter, Lilly Paul, Renee Richardson, Brandon Ramdass, Aisha Ali and Kameel Mungrue
Article Type: Research Article | First Published: March 24, 2015
301 participants were entered into the study. There was ethnic disparity but a reversal from South East to Africans. A strong inverse linear relationship (Pearson's coefficient r=-0.82, p ≤ 0.05) was found between BMI and age at diabetes onset. Between the 1990's and 2004-2014 in two regions of Trinidad the number of patients with T2DM doubled, occurring more commonly among females, the obese and overweight, a tendency towards younger age groups and those of lower socioeconomic status (SES...
