Diabetes mellitus (DM), a cluster of metabolic diseases, resulting in high blood glucose levels, is prevalent in today's world. The global costs of diabetes and its consequences are rising and are expected substantially increase by 2030, especially in middle- and lower-income countries. Evidence-based therapies, specifically targeting the reduction of high blood glucose levels, and minimizing diabetic complications, are currently the choice of treatment. Stem cell therapy offers a promising visi...

According to the World Health Organization, the mantle cell lymphoma is a lymphoma subtype characterized by the translocation t (11;14) resulting in overexpression of the protein cyclin D1+. The clinical presentation typically includes extranodal, particularly bone marrow and gastrointestinal tract. Of all B cell lymphomas, it has the worst prognosis and survival, around 3 to 5 years....

Besides invention of iPSC technology, recent progress of stem cell-based organoids is founded on long-standing 3D-reaggregate approaches from embryonic tissues. In particular, histotypic in vitro reconstruction of avian retinal spheroids was most prolific. For instance, a complete reconstitution of all retinal layers was possible, which was supported by Wnt signalling and factors from the retinal pigmented epithelium (RPE); similar in vitro findings are still missing for mammals. Using an establ...