Open Access DOI:10.23937/2469-570X/1410070
Therapeutic Effect of Intravenously Administered Autologous Adipose-Derived Stem Cells on Chronic Stage Stroke Patients
Masamitsu Ichihashi, MD, PhD, Masaki Tanaka, MD, PhD, Takashi Iizuka, Narumi Nagoe, Youko Sato, Hitomi Takahashi, Asami Ueda, Hiroko Totsuka, Narumi Takanashi, Takahito Nishikata, PhD, Osamu Matsuo, MD, PhD, Hideya Ando, PhD and Ken-ichiMizutani, PhD
Article Type: Original Article | First Published: December 10, 2020
Intravenous transplantation of mesenchymal stem cells derived from bone marrow and adipose tissue has been reported to be effective, safe and promising in the recovery of clinical outcomes of the stroke patients at acute and subacute stages, but clinical studies at chronic stages are still limited. It is reported that for better recovery of neurological dysfunction, cell therapy is recommended as early as possible after stroke onset. To our knowledge, clinical studies on stem cell therapy of str...
Open Access DOI:10.23937/2469-570X/1410071
Loss of Tissue Regenerative Capacity in Aging - The Tendon
Pedro Carvalho Sá, Margarida Pimenta Queiroz Valério, Inês Monteiro Ferro Inês Campos and Lina Carvalho
Article Type: Original Article | First Published: December 10, 2020
Intrinsic to the process of aging is the loss of the ability to regenerate of different organs and tissues, becoming more susceptible to aggression and impaired function. Tendon aging is a complicated process following, however, similar mechanisms of other tissues - proposed model of the “Hallmarks of Aging”, by López-Otín, et al. Tendon structure and cellular composition is also unique, which makes scientific research in this field both a very specific and select task. Mesenchymal Stem Ce...
Open Access DOI:10.23937/2469-570X/1410069
Stembell Therapy Reduces Macrophages in Atherosclerotic Aortic Valves after Myocardial Infarction
Amber van Broekhoven, MD, Linde Woudstra, PhD, Elisa Meinster, Laura van Haren, Amber M Kay, Marit Koopman, Martine C Morrison, PhD, Marco N Helder, MD, PhD, Lynda J Juffermans, PhD, Casper G Schalkwijk, PhD, Hans WM Niessen, MD, PhD, Alexander BA Vonk, MD, PhD and Paul AJ Krijnen, PhD
Article Type: Original Research | First Published: July 08, 2020
Previously, we have shown that StemBell therapy (i.e. mesenchymal stem cell-microbubble complexes subjected to ultrasound) reduced plaque inflammation and plaque destabilization in the aortic root, and thereby inhibited atherosclerosis exacerbation after myocardial infarction (MI). MI also has an effect on heart valves as it increases valve thickness and remodeling. Moreover, hemodynamic disturbances following MI have also been suggested to affect aortic valve (AV) pathology. Therefore, we have ...
Open Access DOI:10.23937/2469-570X/1410066
Clinical Relevance of RNA Editing to Early Detection of Cancer in Human
Mujib Ullah and Asma Akbar
Article Type: Editorial | First Published: March 14, 2020
DNA encodes RNA and is responsible for protein production in cells. RNA editing is the process by which genetic information is altered in the RNA molecule. RNA editing in cancer initiation, progression and development has been well documented and play an important role in tumorigenesis. Studying RNA editing and its application to change genetic information after transcription, RNA-editing technology could be an important innovation in cancer and has the potential for more effective precision tre...
Open Access DOI:10.23937/2469-570X/1410065
The Blood Levels of the Amino Acid Kynurenine and Indoloxigenase are Predictive of Acute Graft Versus Host Disease (aGVHD)
Ferreira DC, Silva IDCG, Lo Turco EG and Oliveira JSR
Article Type: Research article | First Published: January 25, 2020
The main barrier to the success of hematopoietic stem cell transplantation (HSCT) is acute graft versus host disease (aGVHD). The risk factors for aGVHD are mainly clinical and can be improved if additional biological factors are incorporated, such as the metabolomic profile. It is known that the levels of various metabolites measured are important in the process of immunoregulation. In our population study we investigated the systemic metabolic profile for 26 (Group I) allotransplant recipients...
