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Toxicology and Risk AssessmentISSN: 2572-4061

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 Open Access DOI:10.23937/2572-4061.1510061

Toxicological Studies of Eucalyptus camaldulensis Dehnh. (Myrtaceae) Essential Oil for the Safety of Its Insecticidal Application

Sylvain Ilboudo, Bapio Valérie Elvira Jean Télesphore Bazié, Jean Noël Dado Koussé, Geoffroy Gueswindé Ouédraogo, Gaétan D. SOMDA, Ignace Sawadogo, Moussa Ouédraogo, Roger C.H. Nebie and Sylvin Ouédraogo

Article Type: Research Article | First Published: 2024/07/18

Eucalyptus camaldulensis Dehnh (Myrtaceae) (E. camaldulensis) or red gum is a plant whose essential oil (EO) is recognized for its insecticidal, antibacterial, and antifungal properties. Imported from Australia and introduced to other continents whose Africa, its EO is used in Burkina Faso to formulate biopesticides....

 Open Access DOI:10.23937/2572-4061.1510060

Contamination Levels of Heavy Metals and Assessment of Potential Health Risks in Food Samples in the Democratic Republic of Congo (DRC): A Systematic Review

Mputu Malolo Lievins-Corneille, Mankulu Kakumba Jocelyn, Ndelo Matondo Patrick, Nuapia Belo Yannick and Ndelo-di-Phanzu Josaphat

Article Type: Review Article | First Published: 2024/07/17

Food safety and human health are both negatively impacted when heavy metals are present in food. The objective of this review was to summarise the available data on food contamination with heavy metals (HMs) in the Democratic Republic of the Congo and offer suggestions for developing the field of HMs risk assessment. We searched PubMed/MedLine, Google Scholar, Sciencedirect, and EMBASE extensively for articles on exposure levels to trace elements in DR C (2011-2021). Ten documents in all, five o...

 Open Access DOI:10.23937/2572-4061.1510059

SPE-HPLC-UV Analysis of Phthalates in Biological Fluids of Transfused Mothers in Sacred-Heart Hospital Lantoro Abeokuta Nigeria

Olumayowa Joshua Onipede, Gregory Olufemi Adewuyi, Adejumoke Idowu Ayede, Oladapo Olayemi, Folasade Adenike Bello, Jonathan O. Osamor and Gregory Olawole Arifalo

Article Type: Research Article | First Published: 2024/07/12

Exposure to phthalates through blood transfusion has been a concern of research, as studies have been inconclusive on their leaching of phthalates to the blood of the transfused patient. This study examined levels of diethyl phthalate (DEP), dipropyl phthalate (DPP), dibutyl phthalate (DBP), diethylhexyl phthalate (DEHP) and monobutyl phthalate (MBP) in blood serum, urine and breast milk samples of transfused mothers in Sacred Heart Hospital Lantoro Abeokuta Southwest Nigeria. Samples were extra...

 Open Access DOI:10.23937/2572-4061.1510058

Combining Hazard Information from Multiple Dose-Response Experiments for Benchmark Dose Estimation in Risk Assessment

Lucy Kerns

Article Type: Research Article | First Published: 2024/06/19

An important goal of risk assessment is the determination of the minimum dose levels (benchmark doses or BMDs) of a hazardous chemical at which a specified bench mark risk (BMR) is attained. In practice, more than one experiment is often conducted for a hazard to determine the BMD values. In such cases, synthesizing all available hazard information to produce an average BMD value becomes an important task for risk analysts, which can be challenging when there is significant between-experiment he...

 Open Access DOI:10.23937/2572-4061.1510057

Hepatoprotective Efficacy of Phytochemicals in Clerodendrum volubile as Potential Natural Inhibitor on CYP2e1 Protein Implicated for Toxicity in Liver

Ololade Zacchaeus S, Onifade Olayinka F, Olugboye Bolarinde O, Alabi Temidayo E, Faleye Busayo C and Jimson Favour E

Article Type: Review Article | First Published: 2024/06/13

This study delves into the effects of secondary metabolites in Clerodendrum volubile on CYP2e1, a protein target implicated in hepatotoxicity. Among these compounds, cis,cis-linoleic acid, 3-hydroxydecanoic acid, n-pentadecanoic acid, palmitic acid, and 3,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one demonstrate strong binding affinities and stability within the protein's active site compared to standard compounds with lower values. These compounds exhibited notable binding affinities against ...

Volume 10
Issue 1