Open Access DOI:10.23937/2572-3286.1510037
Genetic Deletion of the Lipid Raft Protein Caveolin-1 Leads to Worsening Renal Fibrosis
S Chand, J Hazeldine, SW Smith and R Borrows
Article Type: Research Article | First Published: June 25, 2018
Renal disease is a major global public health issue. Renal interstitial fibrosis is the characteristic histopathological finding in all progressive renal disease. Caveolin-1 is the essential structural protein for lipid rafts called caveolae that are ubiquitously distributed among fibroblasts, endothelial and epithelial cells. Caveolin-1 acts as an intracellular signalling pathway chaperone in fibrotic disease....
Open Access DOI:10.23937/2572-3286.1510036
Alport Syndrome: No Evidence of Improved Prognosis in Modern Era
Kelly YP, Wallis L, Patil A, Murray S, Kant S, Kaballo M5, Casserly L, Doyle B, Dorman T, O'Kelly P and Conlon PJ
Article Type: Research Article | First Published: June 09, 2018
Alport syndrome is an inherited renal disease, first described in 1927, which is characterized by haematuria, renal failure, hearing loss, lenticonus, retinal flecks, a lamellated glomerular basement membrane and mutations in the COL4A5 or COL4A3/COL4A4 genes leading to abnormal Type IV collagen composition. The prevalence of the disease is estimated at 1 in 50,000 live births....
Open Access DOI:10.23937/2572-3286.1510035
Effects of Intra-Dialysis Resistance Training in Hemodynamic Parameters, Oxidative Stress and Health-Related Quality of Life in Patients with Chronic Kidney Disease
Bruna S Lourenco, Marcos A Nascimento, Vicente N Siqueira, Sergio A Draibe, Marco T Mello, Sergio Tufik, Maria EF Canziani and Elisa MS Higa
Article Type: Research Article | First Published: May 06, 2018
Chronic kidney disease is a public health problem that causes severe complications to the patient. The major damage is the loss of muscle mass, with a consequent reduction in the functional capacity that is associated with hypertension and increased oxidative stress. This study aimed to evaluate the effect of intra-dialysis resistance training on the hemodynamic parameters, oxidative stress and quality of life in patients with chronic kidney disease....
Open Access DOI:10.23937/2572-3286.1510034
Effective Role of CVVH in Fatal Phenobarbital Overdose Clearance: A Case Report
Chaudhry Adeel Ebad, Alan Gaffney and Peter J Conlon
Article Type: Case Report | First Published: January 31, 2018
We report affective utilization of continuous veno-venous hemofiltration for removal of phenobarbital in a patient who took twice amount of fatal dose and was hemodynamically stable. Historically treatment includes supportive care, activated charcoal and urinary alkalinisation along with the application of extracorporeal treatments such as charcoal haem perfusion or hemodialysis and continuous veno-venous hemodiafiltration are affective treatment for removal of drug. Early initiation of extracor...
