Open Access DOI:10.23937/2474-3658/1510233
A Randomized Controlled Trial of Ivermectin Monotherapy versus Hydroxychloroquine, Ivermectin, and Azithromycin Combination Therapy in COVID- 19 Patients in Nigeria
Babalola OE, Ndanusa YA, Ajayi AA, Ogedengbe JO, Thairu Y and Omede O
Article Type: Randomised Drug Trial | First Published: October 31, 2021
The efficacy of Ivermectin (IVM) against SARS-CoV-2 has been demonstrated in vitro, while several clinical studies suggest that it is efficacious and safe in reducing morbidity and mortality. Hydroxychloroquine (HCQ, Quinoric®), IVM and Azithromycin(AZM, Zithromax®) (HIA therapy) is being used in several low- and middle-income countries (LMIC) where more expensive medications such as Remdesivir are out of reach. In this study, we set out to compare the efficacy of IVM monotherapy with HIA comb...
Open Access DOI:10.23937/2474-3658/1510232
Sex-Specific Differences in the Short-Term Prevalence Trends of HIV and HBV among Undergraduate Nigerians: Implications for Policy
Henry E Aloh, Sharon O Azubuike-Osu, Cletius Nwabuogu, Miriam Nwankwo and Chukwunonso ECC Ejike
Article Type: Original Article | First Published: October 30, 2021
The prevalence of Human Immunodeficiency Virus (HIV) and Hepatitis B Virus (HBV) infections and their co-infection are rarely reported among undergraduate Nigerians. This study sought to provide data in the said direction and discuss policy imperatives. A population of 4,876 undergraduate students of the Alex Ekwueme Federal University, Ndufu-Alike (AEFUNAI), Nigeria (52.7% females; mean age: 20 ± 2 yrs, females; 20 ± 3 yrs, males) was studied. Standard procedures were used for collection and ...
Open Access DOI:10.23937/2474-3658/1510231
Predictors of Pulmonary Cavitation among Tuberculosis Patients
Oluwafemi O Balogun, Adetayo Fawole, Etiosa Osemwinyen and Busola Balogun
Article Type: Original Article | First Published: October 30, 2021
Globally, Tuberculosis (TB) remains one of the top ten causes of mortality. Furthermore, the incidence and prevalence of the disease spectrum remain high in lowand some middle-income countries. Due to the associated high morbidity and mortality, the World Health Organization (WHO) declared it a public health emergency. Furthermore, pulmonary cavitation, classified epidemiologically and clinically as the hallmark of TB, has been associated with increased bacillary burden, high infection transmiss...
Open Access DOI:10.23937/2474-3658/1510230
An Accuracy-Based Approach to the Microbiologic Diagnosis of Pulmonary Infection
John Ferguson, MD, MPH, Cyprien Jungels, DO and Michael Gailey, DO
Article Type: Review Article | First Published: October 22, 2021
Over six million cases of pneumonia are diagnosed annually in the United States. Clinicians commonly experience uncertainty regarding the accuracy of laboratory tests as these values are not well-published or easily accessible. Performance data of diagnostic tests are needed to assist clinicians in procuring a microbiologic diagnosis. We undertook a literature search to assess the accuracy of diagnostic tests for pneumonia, identified through a search of MEDLINE-indexed journals. Sensitivity and...