Autoimmune Hepatitis (AIH) is a chronic necroinflammatory liver disease of unknown etiology associated with circulating autoantibodies and high serum globulin level. Systemic lupus erythematous (SLE) is a disease of unknown etiology in which tissues and cells are damaged by pathogenic autoantibodies and immune complex, affecting multiple organs including the liver, kidney, and CNS. AIH has been considered to occur infrequently in SLE. We report a 42-year-old female patient with an overlap syndrome involving autoimmune hepatitis (AIH) and systemic lupus erythematous (SLE). The patient presented with jaundice, arthralgias, fatigue, jaundice, mild fever, and abdominal discomfort. Laboratory tests revealed severe liver dysfunction, a positive ANA/anti-dsDNA test. A liver biopsy showed acute hepatitis with severe inflammatory activity that goes with autoimmune hepatitis. The patient satisfied the international criteria for both SLE and AIH. Clinical symptoms and laboratory findings of SLE improved with appropriate treatment by corticosteroids and azathioprine, and remission of the liver disease was achieved as well.