Table 1: Newer Enzymatic Markers of Pancreatitis
| Marker | Sensitivity % | Specificity% | Significance | Number of subjects in the studies |
| Pancreatitis associated protein (PAP) [7] | 100 | 94 | Useful in diagnosis, but may not be a good marker for establishing severity. | 70 |
| Phosholipase A2 levels [8] | 75 | 78 | Role in pulmonary dysfunction can differentiate mild from severe pancreatitis as early as day 1. The diagnostic accuracy is low when compared to other biomarkers [9]. | 85 |
| Trypsinogen activated peptide [10-12] | 58 (severity) | 73 (severity) | Serum levels are the best and earliest marker of acute pancreatitis. Urine TAP levels are more sensitive than amylase and lipase [13]. Can differentiate mild from severe forms and urinary detection adds to ease of establishing a diagnosis. | 55-246 patients |
| Serine Protease inhibitor Kazal Type 1 and Human pancreatic secretory trypsin inhibitor [14] | 71 (in predicting severity) | 77 (in predicting severity) | Not widely available, more sensitive than CRP in predicting severity of acute pancreatitis. | 26 |
| Tryspsinogen-2 and Trypsin-2-alpha 1 antitrypsin complex [15-17] | 91(severity) | 71 (severity) | Useful in assessing the severity of pancreatitis. The sensitivity and specificity are similar to amylase and lipase [18]. Trypsinogen 2 is useful in diagnosing CRP associated pancreatitis. | 31 to 100 patients |
| Procarboxypeptidase B and carboxypeptidase B activation peptide (CAPAP) [19,20] | Procarboxypeptidase is similar in sensitivity to amylase and lipase. Persists for longer so useful in late stages. At day 3 it is useful in differentiating mild from severe forms. Carboxypeptidase B, can be detected in urine and a good marker of severity. |