Level 1: Title and abstract screening (n = 147)

Irrelevant exposure

Irrelevant (no quinolone tested)

23

Irrelevant publication type

Case report/case series

101

Letter/commentary

19

Report

3

Conference abstract

1

Level 2: Full-text examination (n = 2,527)

Irrelevant exposure

Quinolone combined with other drugs

294

Cross-over trial

196

Trial with multiple arms

150

Quinolone in a topical formulation

129

Trial with a single arm

100

Quinolones on multiple arms

73

Irrelevant methods

Observational study

147

Review article

102

Not a clinical trial

17

Irrelevant outcome

No results available

181

Current or prior eye disease

7

Unavailable full-text

Reference could not be retrieved

13

Non-original

Additional reports on original studies

973

Eligible trials with no RD

Eligible trial with no reporting on RD

145