Table 1: Reported cases of penile MPNST in the current literature [11-16].

Author (year) NF1 Age at diagnosis (years) Size (cm) Location Treatment Outcome
Dehner (1970) Yes 15 4.0 Prepuce, glans Partial excision Lost to follow-up
Dehner (1970) Yes 2 2.5 Dorsal shaft Excision Recurrence (4x) at same location in 2 years
Aloi (1995) No 58 1 Glans Excision No metastasis at 1-year follow-up
van Eck (2006) Not reported 74 Not reported Not reported Partial penile amputation - Inguinal metastasis at 7 years → resection & radiation (64.8 Gy)
- Gall bladder metastasis at 8 years → cholecystectomy
- Multiple brain metastasis at 9 years → gamma knife surgery (2x)
Mortell (2007) No 3 1.3 × 0.7 × 0.4 Dorsal shaft Excision with positive margins → re-resection at 3 months - Local recurrence (2x) & resection (2x) at 4 and 4.5 years
- No recurrence at 5.5 years
Parekh
(2013)
No 14 months 5.4 × 3.7 × 3.8 Base of penis - Chemotherapy (2 cycles doxorubicin & ifosfamide) with 35% growth - Total penectomy (+ margins) - Radiation (5580 cGy total) No recurrence or metastasis at 9 months
Kaur
(2015)
No 38 3.6 × 2.3 × 2.2 Base of penis - Resection (3 mm margin) → corpora excision
- Radiation (60 Gy in 30 fractions)
- Chemotherapy (6 cycles doxorubicin & ifosfamide)
No recurrence or metastasis at 3 months