Table 2: American joint committee on cancer TMN classification for penile cancer.
Primary Tumor (T) |
TX Primary tumor cannot be assessed T0 No evidence of primary tumor Tis Carcinoma in situ Ta Noninvasive verrucous carcinoma* T1a Tumor invades subepithelial connective tissue without lymph vascular invasion and is not poorly differentiated (i.e., grade 3-4) T1b Tumor invades subepithelial connective tissue with lymph vascular invasion and is poorly differentiated T2 Tumor invades corpus spongiosum or cavernosum T3 Tumor invades urethra T4 Tumor invades other adjacent structures *Note: Broad pushing penetration (invasion) is permitted; destructive invasion is against this diagnosis. Regional Lymph Nodes (N) |
Clinical Stage Definition* cNX Regional lymph nodes cannot be assessed cN0 No palpable or visibly enlarged inguinal lymph nodes cN1 Palpable mobile unilateral inguinal lymph node cN2 Palpable mobile multiple or bilateral inguinal lymph nodes cN3 Palpable fixed inguinal lymph nodal mass or pelvic lymphadenopathy unilateral or bilateral *Note: Clinical stage definition based on palpation, imaging. Pathologic Stage Definition* |
pNX Regional lymph nodes cannot be assessed pN0 No regional lymph node metastasis pN1 Metastasis in a single inguinal lymph node pN2 Metastasis in multiple or bilateral inguinal lymph nodes pN3 Extranodal extension of lymph node metastasis or pelvic lymph node(s) unilateral or bilateral *Note: Pathologic stage definition based on biopsy or surgical excision Distant Metastasis (M) |
M0 No distant metastasis M1 Distant metastasis* *Note: Lymph node metastasis outside of the true pelvis in addition to visceral or bone sites. |