Table
2: Simulation
results when true hazard ratio = 1.
Control median |
Sample size |
Percent censored |
Bias |
ASE |
ESD |
Proportion of HR |
||
< 0.5 |
< 0.4 |
< 0.3 |
||||||
6 |
800 |
6.8 |
0.0009 |
0.0733 |
0.0733 |
0.0000 |
0.0000 |
0.0000 |
600 |
6.7 |
0.0011 |
0.0847 |
0.0864 |
0.0000 |
0.0000 |
0.0000 |
|
400 |
6.8 |
-0.0021 |
0.1038 |
0.1067 |
0.0000 |
0.0000 |
0.0000 |
|
200 |
6.8 |
0.0009 |
0.1473 |
0.1484 |
0.0000 |
0.0000 |
0.0000 |
|
100 |
6.8 |
-0.0007 |
0.2092 |
0.2124 |
0.0004 |
0.0000 |
0.0000 |
|
50 |
6.9 |
0.0031 |
0.2991 |
0.3049 |
0.0112 |
0.0018 |
0.0000 |
|
12 |
800 |
25.5 |
0.0018 |
0.0820 |
0.0835 |
0.0000 |
0.0000 |
0.0000 |
600 |
25.6 |
-0.0015 |
0.0948 |
0.0949 |
0.0000 |
0.0000 |
0.0000 |
|
400 |
25.5 |
0.0018 |
0.1160 |
0.1165 |
0.0000 |
0.0000 |
0.0000 |
|
200 |
25.6 |
-0.0053 |
0.1646 |
0.1661 |
0.0002 |
0.0000 |
0.0000 |
|
100 |
25.7 |
0.0028 |
0.2338 |
0.2360 |
0.0022 |
0.0002 |
0.0000 |
|
50 |
26.0 |
-0.0099 |
0.3341 |
0.3357 |
0.0198 |
0.0036 |
0.0002 |
|
24 |
800 |
50.3 |
0.0013 |
0.1005 |
0.1017 |
0.0000 |
0.0000 |
0.0000 |
600 |
50.3 |
0.0012 |
0.1160 |
0.1168 |
0.0000 |
0.0000 |
0.0000 |
|
400 |
50.3 |
0.0031 |
0.1422 |
0.1421 |
0.0000 |
0.0000 |
0.0000 |
|
200 |
50.4 |
-0.0015 |
0.2019 |
0.2006 |
0.0008 |
0.0000 |
0.0000 |
|
100 |
50.4 |
-0.0035 |
0.2875 |
0.2902 |
0.0112 |
0.0020 |
0.0000 |
|
50 |
50.8 |
-0.0062 |
0.4136 |
0.4207 |
0.0520 |
0.0162 |
0.0030 |
Median
HR rounded to two decimal places was 1.00 in all cases except for two cases
when it was 0.99 (Control median = 12, Sample size = 200 and Control median = 12,
Sample size = 50).