Table 1: Sample description of the ACTG175 study variables considered by the PRIM algorithm. The arms are labeled as 0 = zidovudine, 1 = zidovudine and didanosine, 2 = zidovudine and zalcitabine, 3 = didanosine.
Treatment Group |
|||||
Variable |
0 (n = 532) |
1 (n = 522) |
2 (n = 524) |
3 (n = 561) |
P-value |
Age ≤ 30 (30,40] (40,50] > 50 |
166 (0.31) 237 (0.45) 102 (0.19) 27 (0.05) |
164 (0.31) 233 (0.45) 101 (0.19) 24 (0.05) |
164 (0.31) 235 (0.45) 95 (0.18) 30 (0.06) |
177 (0.32) 251 (0.45) 111 (0.20) 22 (0.04) |
0.984 |
Weight (kg) ≤ 60 (60,70] (70,80] > 80 |
44 (0.08) 138 (0.26) 177 (0.33) 173 (0.33) |
63 (0.12) 126 (0.24) 175 (0.34) 158 (0.30) |
58 (0.11) 132 (0.25) 172 (0.33) 162 (0.31) |
66 (0.12) 132 (0.24) 192 (0.34) 171 (0.30) |
0.749 |
Hemophilia No Yes |
490 (0.92) 42 (0.08) |
479 (0.92) 43 (0.08) |
478 (0.91) 46 (0.09) |
512 (0.91) 49 (0.09) |
0.946 |
Homosexual activity No Yes |
191 (0.36) 341 (0.64) |
176 (0.34) 346 (0.66) |
176 (0.34) 348 (0.66) |
182 (0.32) 379 (0.68) |
0.679 |
Karnofsky score 70 80 90 100 |
4 (0.01) 17 (0.03) 197 (0.37) 314 (0.59) |
0 (0.00) 22 (0.04) 189 (0.36) 311 (0.60) |
3 (0.01) 18 (0.03) 180 (0.34) 323 (0.62) |
2 (0.00) 23 (0.04) 221 (0.39) 315 (0.56) |
0.500 |
Prior antiretroviral therapy No Yes |
516 (0.97) 16 (0.03) |
513 (0.98) 9 (0.02) |
511 (0.98) 13 (0.02) |
552 (0.98) 9 (0.02) |
0.350 |
Race White Non-white |
376 (0.71) 156 (0.29) |
384 (0.74) 138 (0.26) |
374 (0.71) 150 (0.29) |
388 (0.69) 173 (0.31) |
0.452 |
Gender Female Male |
100 (0.19) 432 (0.81) |
88 (0.17) 434 (0.83) |
89 (0.17) 435 (0.83) |
91 (0.16) 470 (0.84) |
0.708 |
Baseline CD4 count ≤ 15.3 (15.3,18.4] (18.4,21.6] > 21.6 |
75 (0.14) 182 (0.34) 197 (0.37) 78 (0.15) |
98 (0.19) 175 (0.34) 171 (0.33) 78 (0.15) |
88 (0.17) 175 (0.33) 173 (0.33) 88 (0.17) |
86 (0.15) 197 (0.35) 201 (0.36) 77 (0.14) |
0.528 |
Baseline CD8 count ≤ 6.32 (6.32,6.79] (6.79,7.26] > 7.26 |
72 (0.14) 197 (0.37) 190 (0.36) 73 (0.14) |
79 (0.15) 173 (0.33) 183 (0.35) 87 (0.17) |
69 (0.13) 181 (0.35) 195 (0.37) 79 (0.15) |
88 (0.16) 192 (0.34) 203 (0.36) 78 (0.14) |
0.813 |