Table 2: Sample description of the SUCCESS-A study variables considered by the PRIM algorithm, including the BRCA1-defined cluster id. Patients were randomized to either standard of care (arm AB) or standard of care plus Gemcitabine (arm AA).
Variable |
Treatment |
||
AA (n = 1590) |
AB (n = 1624) |
P-value |
|
ER status Positive Negative |
1086 (0.68) 504 (0.32) |
1132 (0.70) 492 (0.30) |
0.411 |
HER2 status Positive Negative |
509 (0.32) 1081 (0.68) |
484 (0.30) 1140 (0.70) |
0.188 |
PR status Positive Negative |
1003 (0.63) 587 (0.37) |
1046 (0.64) 578 (0.36) |
0.456 |
Menopause status Premenopausal Postmenopausal |
667 (0.42) 923 (0.58) |
653 (0.40) 971 (0.60) |
0.334 |
Grade G1 (well differentiated) G2 (moderately differentiated) G3 (poorly differentiated) |
81 (0.05) 763 (0.48) 746 (0.47) |
68 (0.04) 778 (0.48) 778 (0.48) |
0.451 |
T stage pT0 pT1 pT2 pT3 pT4 |
1 (0.00) 657 (0.41) 830 (0.52) 81 (0.05) 21 (0.01) |
0 (0.00) 672 (0.41) 838 (0.52) 90 (0.06) 24 (0.01) |
0.823 |
N stage pN0 pN1 pN2 pN3 |
570 (0.36) 697 (0.44) 229 (0.14) 94 (0.06) |
561 (0.35) 747 (0.46) 213 (0.13) 103 (0.06) |
0.487 |
Tumor type Invasive ductal Invasive lobular Other invasive epithelial breast cancer |
1252 (0.79) 165 (0.10) 173 (0.11) |
1278 (0.79) 175 (0.11) 171 (0.11) |
0.899 |
Age categorized (-Inf,50] (50,65] (65, Inf] |
654 (0.41) 693 (0.44) 243 (0.15) |
639 (0.39) 727 (0.45) 258 (0.16) |
0.583 |
BMI categorized (-Inf,25] (25,30] (30, Inf] |
739 (0.46) 537 (0.34) 314 (0.20) |
771 (0.47) 513 (0.32) 340 (0.21) |
0.387 |
CLUSTER ID 1 2 3 4 5 6 7 8 9 |
144 (0.09) 150 (0.09) 353 (0.22) 139 (0.09) 156 (0.10) 169 (0.11) 254 (0.16) 155 (0.10) 70 (0.04) |
159 (0.10) 123 (0.08) 345 (0.21) 142 (0.09) 185 (0.11) 161 (0.10) 265 (0.16) 172 (0.11) 72 (0.04) |
0.538 |