Table 1: Classification and causes of PH [36].
Types | Causes |
Group 1 Pulmonary Arterial Hypertension |
• No known cause: Idiopathic (IPAH) • Inherited: Heritable (HPAH) • Caused by drugs/toxins • Caused by conditions(APAH): HIV, Liver disease etc., |
Group 2 Pulmonary Hypertension |
• PH with left heart disease • Caused by conditions that affect the left side of the heart: Mitral valve disease, High blood pressure |
Group 3 Pulmonary Hypertension |
• PH associated with lung diseases: COPD, Interstitial lung disease |
Group 4 Pulmonary Hypertension |
• Caused by blood clots in the lungs • Caused by blood clotting disorders |
Group 5 Pulmonary Hypertension |
• Caused by unclear multifactorial mechanisms: Blood disorders System disorders Metabolic disorders Other conditions like tumor |