Table 4: Characteristics of the individual and total studies examined the association between acute ischemic stroke and PON1 gene Q192R polymorphism in Turkish population.
Study |
Region |
Q192R |
Patients |
Controls |
p |
OR (CI 95%) |
|
Aydin et al., 2006 (24) |
İstanbul |
Genotypes |
|||||
QQ : QR : RR |
14 (21.5) : 40 (61.5) : 11 (16.9) |
38 (45.2) : 35 (41.7) : 11 (13.1) |
0.010 |
- |
|||
QQ : QR+RR |
14 (21.5) : 51 (78.5) |
38 (45.2) : 46 (54.8) |
0.003 |
0.332 (0.160-0.690) |
|||
QQ+QR : RR |
54 (83.1) : 11 (16.9) |
73 (86.9) : 11 (13.1) |
0.514 |
0.740 (0.299-1.832) |
|||
Alleles |
|||||||
Q : R |
68 (52.3) : 62 (47.7) |
111 (66.1) : 57 (33.9) |
0.016 |
0.563 (0.352-0.901) |
|||
Demirdöğen et al., 2009 (26) |
Ankara |
Genotypes |
|||||
QQ : QR : RR |
77 (44.8) : 74 (43.0) : 21 (12.2) |
46 (43.8) : 50 (47.6) : 9 (8.6) |
0.572 |
- |
|||
QQ : QR+RR |
77 (44.8) : 95 (55.2) |
46 (43.8) : 59 (56.2) |
0.876 |
1.040 (0.638-1.695) |
|||
QQ+QR : RR |
151 (87.8) : 21 (12.2) |
96 (91.4) : 9 (8.6) |
0.345 |
0.674 (0.296-1.533) |
|||
Alleles |
|||||||
Q : R |
228 (66.3) : 116 (33.7) |
142 (67.6) : 68 (32.4) |
0.745 |
0.941 (0.653-1.356) |
|||
Present study |
Tokat |
Genotypes |
|||||
QQ : QR : RR |
78 (72.9) : 23 (21.5) : 6 (5.6) |
58 (58.6) : 36 (36.4) : 5 (5.1) |
0.061 |
- |
|||
QQ : QR+RR |
78 (72.9) : 29 (27.1) |
58 (58.6) : 41 (41.4) |
0.030 |
1.901 (1.060-3.411) |
|||
QQ+QR : RR |
101 (94.4) : 6 (5.6) |
94 (94.9) : 5 (5.1) |
0.859 |
0.895 (0.264-3.032) |
|||
Alleles |
|||||||
Q : R |
179 (83.6) : 35 (16.4) |
152 (76.8) : 46 (23.2) |
0.079 |
1.548 (0.948-2.526) |
|||
Total studies |
Genotypes |
||||||
QQ : QR : RR |
169 (49.1) : 137 (39.8) : 38 (11.0) |
142 (49.3) : 121 (42.0) : 25 (8.7) |
0.587 |
- |
|||
QQ : QR+RR |
169 (49.1) : 175 (50.9) |
142 (49.3) : 146 (50.7) |
0.965 |
0.993 (0.726-1.358) |
|||
QQ+QR : RR |
306 (89.0) : 38 (11.0) |
263 (91.3) : 25 (8.7) |
0.323 |
0.765 (0.450-1.302) |
|||
Alleles |
|||||||
Q : R |
475 (69.0) : 213 (31.0) |
405 (70.3) : 171 (29.7) |
0.624 |
0.942 (0.740-1.198) |
PON1, Paraoxinase 1. The results that are statistically significant are shown in boldface.