Table 4: Association of loci or haplotypes with case-control status in multivariable logistic regression using additive coding.
Allele and gene description |
Parameter estimate (SE) |
p-value* |
rs352038 (CXCL3) |
0.205 (0.088) |
0.67 |
rs2234693 (ESR1) |
0.220 (0.111) |
0.048 |
rs9340799 (ESR1) |
-0.115 (0.113) |
0.31 |
rs3020314 (ESR1) |
0.019 (0.119) |
0.88 |
rs1255998 (ESR2) |
0.136 (0.184) |
0.46 |
rs944050 (ESR2) |
0.587 (0.315) |
0.062 |
rs4775936 (CYP19A1) † |
-0.156 (0.102) |
0.12 |
rs28366003 (MT2A) |
-0.053 (0.227) |
0.81 |
rs3918249 (MMP9) |
0.052 (0.115) |
0.65 |
rs12011793 (AR X) |
0.154 (0.207) |
0.46 |
rs12011518 (AR X) |
-0.190 (0.217) |
0.38 |
ESR1Hap†-rs2234693:rs9340799:rs3020314 |
|
|
CGC-CAT |
-0.175 (0.357) |
0.62 |
CGT-CAT |
-0.188 (0.289) |
0.52 |
TAC-CAT |
0.063 (0.285) |
0.82 |
TAT-CAT |
-0.011 (0.267) |
0.97 |
TGC-CAT |
-0.645 (0.543) |
0.23 |
TGT-CAT |
0.224 (0.314) |
0.48 |
CAC-CAT |
-1.906 (0.931) |
0.041 |
CGC-CAC |
1.731 (0.918) |
0.059 |
CGT-CAC |
1.718 (0.869) |
0.048 |
TAC-CAC |
1.969 (0.875) |
0.024 |
TAT-CAC |
1.896 (0.872) |
0.03 |
TGC-CAC |
1.261 (0.986) |
0.2 |
TGT-CAC |
2.130 (0.887) |
0.016 |
CGT-CGC |
-0.013 (0.281) |
0.96 |
TAC-CGC |
0.238 (0.283) |
0.4 |
TAT-CGC |
0.165 (0.259) |
0.53 |
TGC-CGC |
-0.470 (0.542) |
0.39 |
TGT-CGC |
0.399 (0.315) |
0.21 |
TAC-CGT |
0.251 (0.167) |
0.13 |
TAT-CGT |
0.177 (0.148) |
0.23 |
TGC-CGT |
-0.457 (0.495) |
0.36 |
TGT-CGT |
0.412 (0.224) |
0.067 |
TAT-TAC |
-0.074 (0.148) |
0.62 |
TGC-TAC |
-0.708 (0.500) |
0.16 |
TGT-TAC |
0.161 (0.227) |
0.48 |
TGC-TAT |
-0.635 (0.483) |
0.19 |
TGT-TAT |
0.234 (0.219) |
0.28 |
TGT-TGC |
0.869 (0.547) |
0.11 |
ESR2Hap -rs1255998:rs944050 |
|
|
CA-GG |
-0.580 (0.316) |
0.066 |
GA-GG |
-0.646 (0.362) |
0.074 |
CA-GA |
0.067 (0.215) |
0.76 |
ARHap -rs12011793:rs12011518†† |
|
|
CG-TG |
0.126 (0.614) |
0.84 |
CT-TG |
-0.184 (0.218) |
0.4 |
CG-CT |
0.310 (0.655) |
0.64 |
CXCL = chemokine (C-X-C motif) ligand 3; ESR1 = estrogen receptor 1; ESR2 = estrogen receptor 2; CYP19A1 = cytochrome P450, family 19, subfamily A, polypeptide 1; MT2A = metallothionein 2A; MMP9 = matrix metallopeptidase 9; AR = androgen receptor.
*Multivariable model included: age at diagnosis, non-Hispanic African-American race, marital status, BMI, ever tried to lose weight, smoking status, pack-years smoking, history of endometriosis, history of breast cancer, history of ovarian cancer, history of uterine fibroids, endometrial cancer in 1st degree relative, years of oral contraceptive use, years of unopposed estrogen use, menopause after age 56, menopause status, number of protein shakes per week, 5 or more servings per week whole milk; †Log2-transformed adjusted cadmium concentration was not included in models for rs4775936 and ESR1hap; ††Only one copy of the TT allele was identified so not included in haplotype analysis.