Table 3: Effect of CoQ10, NAC or their combination on serum total protein, albumin, creatinine and creatinine clearance.
Groups | Total Protein (g/dL) | Albumin (g/dL) | Creatinine (mg/dL) | Creatinine clearance (mL/min) |
Control | 7.55 ± 0.071 | 3.65 ± 0.042 | 0.426 ± 0.032 | 1.134 ± 0.088 |
STZ DN | 4.83 ± 0.152a | 1.55 ± 0.154a | 2.96 ± 0.091a | 0.238 ± 0.017ab |
CoQ10 (10 mg/kg) | 6.25 ± 0.152ab | 2.46 ± 0.055ab | 1.002 ± 0.050ab | 0.615 ± 0.038ab |
NAC (300 mg/kg) | 6.13 ± 0.269ab | 2.61 ± 0.094ab | 1.06 ± 0.046ab | 0.564 ± 0.052ab |
CoQ10 + NAC | 6.78 ± 0.119abd | 2.96 ± 0.071abd | 0.78 ± 0.036abcd | 0.869 ± 0.083abcd |
Values are expressed as mean ± SEM; n = 6; a: P < 0.001 as compared to normal control group; b: P < 0.001 as compared to diabetic control group; c: P < 0.001 as compared to diabetic CoQ10 alone treated group; d: P < 0.001 as compared to diabetic NAC alone treated group.