Table 1: Commonly accepted classification of CMT based on type with descriptive features.
Type of CMT |
Descriptive Features |
CMT Type 1 |
Autosomal dominant and demyelinating form. The most common form of CMT. |
CMT Type 2 |
Axonal form that is dominantly inherited. |
CMT Type 3 |
Severe form often with early onset. The term Dejerine-Sottas Syndrome may be used to describe those with onset by the age of 3 years. Often have extremely slow nerve conduction velocities. |
CMT Type 4 |
Autosomal recessive, considered rare, and often have systemic manifestations such as cataracts and deafness. |
X-Linked CMT |
CMT in which the affected gene is located on the X-chromosome. Males more often affected than females. CMT1X is the second most common form of CMT. |