Table 2: Effect of total flavonoids extract of P. kotschyi on production of TNF-α and LTB4 by asthmatic patient neutrophil.

Total flavonoid extract

(µg.ml-1)

TNF-α production inhibition (%)

P value

LTB4 production inhibition (%)

P value

8

9.09 ± 4.54

ns

6.98 ± 3.85

ns

16

24.12 ± 8.89

***

26.62 ± 0.54

***

32

44.08 ± 7.45

***

51.49 ± 5.95

***

64

66.48 ± 4.76

***

67.46 ± 3.80

***

128

85.83 ± 9.66

***

89.06 ± 6.48

***

IC50

54.07 ± 13.16

 

48.97 ± 3.33

 

***p < 0.001 compared with effect of fMLP (10 mM.ml-1) which was 0% inhibition; Ns: No difference.