Author;
No. of patients
|
Design; Duration,
Intervention
|
Outcomes |
Results |
ARIPIPRAZOLE
|
Warsi et al. (2005) [68]
n=1
|
CR
2 months
SCH + AD
ARI (20 mg/d)
|
Psychiatric symptoms (BPRS)
Daily alcohol used
Alcohol craving (PCS, SRCS)
|
ARI was associated with an improvement in psychiatric symptoms, cessation of daily alcohol intake and reduction in alcohol craving |
Beresford et al. (2005) [69]
n=10
|
Pros, OL study
8 weeks
SCH + COD
ARI (maximum 15 mg/d)
|
Psychiatric symptoms (BPRS)
Cocaine and alcohol craving (UTS, BCRS)
|
Positive UTS dropped significantly (p< 0.001)
Mean cocaine (p=0.026) and alcohol (p=0.006) craving scores significantly declined
Declining psychosis scores were significantly associated with declining cocaine and alcohol craving (p< 0.01)
|
Brown et al. (2005) [70]
n=20
|
OL study
12 weeks
BD (n=19) or SAD (n=1) + AD (n=17) and/or COUD (n=9)
ARI (up to 30 mg/d)
|
Psychiatric symptoms (YMRS, HDRS, BPRS)
Substance craving (VAS)
Substance use (days of use/week, money spent on substances/week and UTS)
|
ARI was associated with significant improvements in psychiatric symptoms (p< 0.05), significant reductions in alcohol craving (p=0.003) and money spent on alcohol/week (p=0.042) and significant reductions in cocaine craving (p=0.014). No significant changes were observed in days/week of alcohol and cocaine use, and in money spent on cocaine/week |
Kim et al. (2010) [37]
n=139
|
Pros, RCT
8 weeks
SCH + ND
OLZ (n=32) or RIS (n=41) or ARI (n=31) or HAL (n=35)
|
Psychopathology (SANS, SAPS)
EPS (AIMS)
Severity of ND and cigarette craving (FTQ)
|
No significant differences in the degrees of change in psychiatric symptoms among the four groups. At 8 weeks, HAL was associated with higher EPS (p< 0.01).HAL was associated with less reduction in the severity of ND (p< 0.01) and cigarette craving (p< 0.01) compared to AAP. Among AAP, RIS increased cigarette craving (p=0.03), there were no significant changes in ND severity and cigarette craving associated with OLZ, and ARI showed a reduction in both severity of ND and cigarette craving (p< 0.01) |
Bruno et al. (2014) [71]
n=20
|
OL study
8 weeks
SAD + OD + MMT
ARI (10 mg/d) + TOP (200 mg/d)
|
Tapering and suppression of MET |
ARI + TOP was effective to achieve MET suppression reducing clinical symptoms |
Farnia et al. (2014) [53]
n=45
|
Pros, DB, RCT
1 year follow-up
AMP induced psychosis
RIS (4 mg/d) or ARI (15 mg/d)
|
Psychopathology (SANS, SAPS) |
SANS and SAPS scores decreased significantly in both groups. Mean SAPS score reduction was greater in the RIS group (p< 0.001). Mean SANS score reduction was greater in the ARI group (p = 0.08) |
AMISULPRIDE
|
Dervaux and Cazali (2007) [72]
n=1
|
CR
Over 25 months
SCH + AD
CLO (600-1200 mg/d) + AMS (600 mg/d)
|
Psychopathology
Alcohol addictive behaviour
|
CLO + AMS was effective in controlling psychiatric symptoms and alcohol addictive behaviour |
Máñez et al. (2010) [73]
n=97
|
Pros study
9 months
SUD (alcohol, cannabis, cocaine and heroin + psychotic symptoms
AMS in two ranges (100-300 mg/D or >400 mg/d, mean dose 493.5 ± 197.1 mg/d)
|
Psychosocial distress
Craving
Psychosocial functioning
|
Overall improvement in their psychological distress, a decrease in carving and an improvement in their psychological and psychosocial functioning |
ZIPRASIDONE
|
Stuyt et al. (2006) [38]
n=55
|
Ret, OL
2 years
SCH (61%) or SAD (54%) + SUD or AUD
Polyvalent SUD (34%), Alcohol (27%), Cocaine (16%), other SUD (21%)
OLZ (2.5-30 mg/d, mean dosage 18.7 mg/d) (n=15) or RIS (n=16) (2-8 mg/d, mean dosage 3.9 mg/d) or ZIP (60-160 mg/d, mean dosage 132.8 mg/d) (n=10) or TAP depot (n=10)
|
Retention rate
Success in completing a DD Programme
|
RIS and ZIP had higher rates of retention compared to OLZ (p=0.0002 and p=0.004, for RIS and ZIP respectively) and TAP (p=0.003 and p=0.03, for RIS and ZIP, respectively). No significant differences in length of stay were found between RIS and ZIP. 88% of RIS patients and 64% of ZIP completed the DD program, whereas only 40% of patients taking TAP and 33% of patients in the OLZ successfully completed the program. This difference in successful completion was statistically significant for RIS vs OLZ (p=0.02) and TAP (p=0.017) |