Table 2: Morphological overlap and dissimilarities between DLB and PDD [2].
Morphological overlap | Morphological dissimilarities |
Mixture of cortical and subcortical LB/αSyn and AD-related pathologies Similar Braak LB stages (4-6) and Braak neuritic stages (5 or 6) Relation between pαSyn and tau aggregation to Aβ deposition in cortex Initial αSyn aggregation in pre-synapses inducing neurodegeneration via interference with axonal transport Postsynaptic protein downregulation |
Higher Aβ load in cortex and striatum in DLB Aβ phases and neuritic plaque scores higher in DLB Higher cortical LB load in temporal & parietal cortex in DLB Increased tau loads in cortex and striatum in DLB More frequent and severe αSyn load in hippocampal subareas CA2 in DLB Differential vulnerability to αSyn pathology in anterior insular cortex (PD > PDD > DLB) Minor deviations in severity and lesion pattern in SNc Pedunculopontine cholinergic cell loss in hallucinating PDD, but not in DLB Higher 5-HT1A receptor binding in cerebral cortex in DLB |