Table 1: Children with AAP treated with octreotide.
Reference |
Age/sex |
Type of ASP/treatment phase |
Type of pancreatitis |
Complications/ Surgery |
Time from last dose of ASP and pancreatitis |
Octreotide dose/duration |
Octreotide side effects |
Re-exposure |
Outcome |
Wu et al. [5] |
8 y/M |
L-asp/ Induction |
NR |
Diabetes/No |
Median 5.2 d (range 2-14 d) |
7.2 µg/kg/d civ for 6 d |
No |
No |
Recovery |
12 y/F |
L-asp/ Induction |
NR |
Diabetes/No |
7.2 µg/kg/d civ for 7 d |
No |
No |
Recovery |
||
13 y/F |
L-asp/ Induction |
NR |
No/No |
7.2 µg/kg/d civ for 4 d |
No |
No |
Recovery |
||
3 y/F |
L-asp/ Induction |
NR |
No/No |
7.2 µg/kg/d civ for 4 d |
No |
No |
Recovery |
||
Cheung et al. [17] |
8 y/F |
L-asp/ Induction |
Edematous |
No/No |
5 d |
5.1-8.7 µg/kg/d iv tid for 44 d |
NR |
Yes, with Erwinia-asp |
Recovery |
Koker et al. [18] |
15 y/F |
L-asp/ Induction |
Edematous |
Hyperglycemia/No |
1 d |
2 μg/kg/h for 5 d |
No |
Yes, with PEG-asp |
Recovery |
2 y/M |
L-asp/ Induction |
Edematous |
No/No |
3 d |
2 μg/kg/h/NR |
No |
Yes, with PEG-asp |
Recovery |
|
Garrington et al. [19] |
5 y/F |
L-asp/ Induction |
Necrotizing |
Pleural effusion, ascites, pseudocyst/No |
6 d |
5 µg/kg/d iv bid for 7 d |
No |
No |
Recovery |
Top et al. [20] |
15 y/F |
L-asp/ Induction |
Necrotizing |
Sepsis, PFC pseudocyst, diabetes*/Yes |
NR |
NR/NR |
NR |
No |
Recovery |
Hatzipantelis et al. [21] |
6.5 y/F |
L-asp/ Induction |
Necrotizing |
No/No |
5 d |
3.6 μg/kg/d civ for 8 d |
Seizures |
NR |
Recovery |
Acer et al. [22] |
9 y/M |
L-asp/NR |
Necrotizing |
Ascites, PFC, necrosis of transverse colon/Yes |
NR |
NR/NR |
NR |
NR |
Recovery |
Plotka et al. [23] |
13 y/M |
PEG-asp/Reinduction |
Necrotizing |
Pleural effusion, ascites, pseudocyst, hyperglycemia/ No |
13 d |
NR/NR |
NR |
No |
Recovery |
Our case |
3 y/M |
PEG-asp/Induction |
Necrotizing |
Pleural effusion, ascites, PFC, pseudocyst, hyperglycemia/No |
10 d |
1 µg/kg/h for 18 d |
No |
No |
Recovery |
F: Female; D: Day; IV: Intravenous; TID: Three Times Daily; BID: Two Times Daily; PFC: (peri)-Pancreatic Fluid Collection; NR: Not Reported; M: Male; CIV: Continuous Intravenous Infusion; Y: Years
*The patient had been on insulin treatment for over a year, and then insulin treatment was stopped.