Table 2: Cases of pediatric necrotizing AAP treated without octreotide, reported in literature.
References |
Age/sex |
Type of asparaginase/ treatment phase |
Complications |
Surgery |
Outcome |
Raizner et al. [4] |
11.5 y/M |
L-asp/NR |
Pleural effusions, ascites, respiratory distress, pseudocyst, diabetes, exocrine insufficiency |
No |
Recovery |
17.8 y/M |
L-asp/NR |
Pleural effusions, ascites, respiratory distress, hyperglycemia, DIC |
No |
Recovery |
|
Sadoff et al. [24] |
5 y/M |
L-asp/Induction |
Sepsis, pseudocyst, retroperitoneal necrosis |
No |
Died |
Sadoff et al. [25] |
5 y/M |
PEG-asp/Induction |
Infected PFC and pseudocyst |
Yes |
Recovery |
M: Male; L-asp: L-Asparaginase; NR: Not Reported; DIC: Disseminated Intravascular Coagulation; PFC: (peri)- Pancreatic Fluid Collection; Y: Years