Reference

Study population

Study type

ARDS etiology

Primary outcome

Secondary outcome

Study quality

Mean duration of PP

Beuret, et al.

51 patients aged 54 (mean)

RCT

Only pneumonia listed

Incidence of lung worsening defined by an increase in the Lung Injury,

Score of at least 1 point

Incidence of VAP

Fair

4 h daily for 6.0 d

Manecebo, et al.

136 patients aged 37-71

RCT

Pneumonia, aspiration, sepsis, multiple trauma

ICU mortality

Hospital mortality, associated complication, and length of stay

Good

17 h daily for 10.1 d

Fernandez, et al.

40 patients aged 36-72

RCT

Only lists pulmonary and extra-pulmonary ARDS

Not specifically expressed.

Outcomes noted were: Mortality, ICU length, mechanical ventilation days, hospital stay, and adverse events

Not specifically expressed,

Outcomes noted were: Mortality, ICU length, mechanical ventilation days, hospital stay, and adverse events

Fair

18 h daily

Guérin, et al.

466 patients aged 42-74

RCT

Being comatose leading to pulmonary infection and closure of small airways with alveolar atelectasis

Mortality at day 28

Mortality at day 90, rate of successful extubation, time to successful extubation, length of ICU stay and complications

Good

17 h daily for 4 d