Table 1: Characteristics of patients with moderate-severe
community-acquired pneumonia
|
Characteristic |
All Patients (n =156) |
Deceased Patients (n =31) |
Survived Patients (n
=125) |
p-value |
Patients with Complications(n = 81) |
Patients without
complications (n = 5) |
p-value |
|
Age
(years)
|
74.36
± 10.78 |
77.07
± 7.78 |
73.69
± 11.32 |
0.06 |
72.33
± 11.71 |
76.55
± 9.26 |
0.01 |
|
Gender |
|
|
|
0.55 |
|
|
0.26 |
|
Male |
83
(53.21%) |
18
(58.06%) |
65
(52%) |
|
47
(58.02%) |
36
(48%) |
|
|
Female |
73
(46.79%) |
13
(41.94%) |
60
(48%) |
|
34
(41.98%) |
39
(52%) |
|
|
Co-morbid
Conditions |
|
|
|
|
|
|
|
|
Chronic
heart disease |
132
(84.62%) |
26 (83.87%) |
106
(84.80%) |
1.000 |
67 (82.72%) |
65 (86.67%) |
0.52 |
|
Chronic
lung disease |
62
(39.74%) |
14
(45.16%) |
48
(38.40%) |
0.54 |
35
(43.21%) |
27
(36%) |
0.41 |
|
Cancer |
42
(26.92%) |
11
(35.48%) |
31
(24.80%) |
0.26 |
16
(19.75%) |
26
34.67%) |
0.05 |
|
Neurologic
disease |
46
(29.49%) |
14
(45.16%) |
32
(25.60%) |
0.05 |
27
(33.33%) |
19
(25.33%) |
0.30 |
|
Chronic
renal disease |
44
(28.21%) |
11
(35.48%) |
33
(26.40%) |
0.37 |
29
(35.8%) |
15
(20%) |
0.03 |
|
Patients
from LTCF |
31
(19.87%) |
8
(25.80%) |
23
(18.40%) |
0.45 |
19
(23.46%) |
12
(16%) |
0.32 |
|
Systemic
steroids use |
41
(26.28%) |
7
(22.58%) |
34
(27.20%) |
0.66 |
21
(25.93%) |
20
(26.67%) |
1.000 |
|
Duration
of symptoms before presentation (days) |
4.95
± 5.44 |
7.68
± 7.97 |
4.24
± 4.34 |
0.04 |
5.14
± 4.75 |
4.74
± 6.14 |
0.67 |
|
Hospitalization
in last 90 days |
35
(22.58%) |
8
(25.81%) |
27
(21.77%) |
0.64 |
17
(20.99%) |
18
(24.32%) |
0.70 |
|
Weekend
admission |
49
(31.41%) |
11
(35.48%) |
38
(30.40%) |
0.67 |
25
(30.86%) |
24
(32%) |
1.000 |
|
Time
to first appropriate antibiotic since time of triage (hours) |
6.62
± 9.01 |
9.35
± 5.76 |
5.95
± 9.54 |
0.01 |
7.39
± 11.46 |
5.79
± 5.16 |
0.26 |
|
First
appropriate antibiotic >4hours
since time of triage |
73
(46.79%) |
23
(74.19%) |
50
(40%) |
0.001 |
37
(45.68%) |
36
(48%) |
0.87 |
|
Time
to first appropriate antibiotic since time of physician assessment (hours) |
4.80
± 5.08 |
8.13
± 5.86 |
3.84
± 4.42 |
0.001 |
4.77
± 5.32 |
4.84
± 4.87 |
0.93 |
|
Time
seen by physician since time of triage (hours) |
0.95 ± 1.20 |
1.04 ± 0.90 |
0.93 ± 1.28 |
0.60 |
1.08 ± 1.33 |
0.82 ± 1.04 |
0.24 |
|
Duration
of antibiotics (days) |
11.05
± 4.61 |
11.07
± 5.93 |
11.04 ± 4.25 |
0.98 |
11.49 ± 5.09 |
10.54
± 3.99 |
0.20 |
|
Length
of hospital stay (days) |
10.48
± 1.53 |
11.29 ± 15.17 |
9.54
± 8.85 |
0.10 |
13.53
± 12.37 |
7.19
± 6.75 |
0.0001 |
|
Patients
on macrolide |
80
(51.28%) |
13
(41.94%) |
67
(53.60%) |
0.32 |
41
(50.62%) |
39
(52%) |
0.87 |
|
Patients
on fluoroquinlones |
43
(27.56%) |
8
(25.81%) |
35
(28%) |
1.000 |
23
(28.40%) |
20
(26.67%) |
0.59 |
|
Positive
culture (respiratory
or blood) |
13
(8.33%) |
2
(6.45%) |
11
(8.80%) |
0.16 |
6
(7.41%) |
7
(9.33%) |
0.11 |
|
Complications |
81
(51.92%) |
27
(87.10%) |
54
(43.20%) |
<
0.0001 |
|
|
|
|
Complications
within 24 hours of admission |
54
(34.62%) |
21
(67.74%) |
33
(26.40%) |
<
0.0001 |
|
|
|
|
Complications
after 24 hours of admission |
59
(37.82%) |
23
(74.19%) |
36
(28.80%) |
<
0.0001 |
|
|
|
|
Cardiac
complications |
13
(8.33%) |
6
(19.35%) |
7
(5.60%) |
0.02 |
|
|
|
|
Death |
|
|
|
|
27
(33.33%) |
4
(5.33%) |
<
0.0001 |
LTCF: long
term care facility
Data expressed as mean ± SD or frequency and percentage as indicated.