Table 1: Infusion details with MSC quality control metrics.
|
Infusion # |
Date of administration (day/month/year) |
Total Cell Count (million) |
Cell viability (%) |
CD73 (%)
|
CD29 (%)
|
CD45 (%)
|
CD31 (%)
|
|
1 |
07/17/2019 |
57.1 |
95.12 |
97.7 |
100.0 |
0.06 |
0.02 |
|
2 |
08/02/2019 |
57.1 |
97.10 |
97.0 |
100.0 |
0.06 |
0.18 |
|
3 |
08/16/2019 |
57.1 |
94.44 |
99.8 |
100.0 |
0.04 |
0.10 |
|
4 |
08/30/2019 |
57.1 |
92.99 |
99.4 |
99.9 |
0.33 |
0.86 |
|
5 |
09/12/2019 |
57.1 |
97.63 |
98.3 |
100.0 |
0.17 |
0.35 |
|
6 |
09/26/2019 |
42.9 |
96.67 |
97.4 |
100.0 |
0.07 |
0.23 |
|
7 |
10/11/2019 |
57.1 |
96.60 |
98.7 |
100.0 |
0.04 |
0.08 |
|
8 |
10/23/2019 |
57.1 |
96.49 |
99.8 |
100.0 |
0.09 |
0.22 |
|
9 |
01/29/2020 |
57.1 |
96.59 |
98.5 |
100.0 |
0.01 |
0.10 |
|
10 |
02/05/2020 |
57.1 |
93.90 |
98.4 |
99.9 |
0.06 |
0.22 |
|
11 |
03/04/2020 |
57.1 |
97.10 |
99.5 |
100.0 |
0.00 |
0.14 |
|
12 |
04/03/2020 |
57.1 |
93.62 |
100.0 |
100.0 |
0.00 |
0.11 |
|
13 |
04/30/2020 |
28.7* |
97.10 |
98.1 |
99.8 |
0.24 |
0.75 |
|
14 |
05/27/2020 |
57.1 |
95.16 |
98.9 |
100.0 |
0.17 |
0.39 |
|
15 |
06/25/2020 |
57.1 |
97.58 |
93.9 |
99.5 |
0.02 |
2.18 |
|
16 |
07/23/2020 |
57.1 |
97.87 |
87.7 |
99.7 |
0.03 |
0.09 |
|
17 |
08/21/2020 |
57.1 |
95.69 |
97.8 |
99.6 |
0.08 |
0.00 |
|
18 |
09/16/2020 |
57.1 |
98.04 |
78.8 |
99.8 |
0.00 |
0.03 |
|
19 |
10/14/2020 |
57.1 |
95.61 |
96.9 |
99.9 |
0.03 |
0.03 |
|
20 |
11/11/2020 |
57.1 |
98.65 |
98.2 |
95.3 |
0.07 |
0.07 |
|
21 |
12/02/2020 |
57.1 |
93.06 |
99.0 |
99.8 |
0.00 |
0.00 |
|
22 |
01/06/2021 |
57.1 |
97.96 |
97.3 |
99.9 |
0.03 |
0.00 |
|
23 |
02/03/2021 |
57.1 |
94.77 |
80.9 |
99.8 |
0.12 |
0.02 |
|
24 |
03/04/2021 |
57.1 |
97.01 |
77.1 |
99.9 |
0.02 |
0.04 |
|
25 |
04/01/2021 |
57.1 |
96.76 |
93.3 |
96.2 |
0.22 |
1.65 |
|
26 |
04/28/2021 |
57.1 |
94.23 |
98.5 |
99.9 |
0.11 |
0.03 |
|
27 |
05/26/2021 |
57.2 |
95.59 |
97.7 |
100.0 |
0.16 |
0.00 |
|
28 |
06/23/2021 |
57.1 |
90.27 |
98.5 |
99.8 |
0.18 |
0.00 |
|
29 |
07/23/2021 |
57.1 |
96.88 |
99.3 |
100.0 |
0.12 |
0.00 |
|
30 |
08/29/2021 |
57.1 |
100.00 |
97.7 |
100.0 |
0.18 |
0.00 |
|
31 |
09/19/2021 |
57.2 |
94.83 |
96.9 |
99.9 |
0.06 |
0.03 |
|
32 |
10/15/2021 |
57.1 |
91.84 |
89.4 |
99.9 |
0.14 |
0.00 |
*Low cell-count due to slower cell growth.
MSCs are expected to be positive for CD73 and CD29 and negative for CD45 and CD31 cell surface markers.