Table 3:
Mobilization of NSCs in neurogenesis of the adult brain
Strategies for NSCs activation |
Niches of NSCs activation |
Expected improvement of CNS injuries |
Learning |
HVC (SVZ) |
Developmental verbal dyspraxia; Mental retardation syndrome Fragile X |
Exercise |
Hippocampus |
Major psychiatric disorders (depression, schizophrenia,
drug addiction); Cerebral infarction; Aging-related cognitive decline |
Stroke |
SVZ |
Stroke |
Muse |
Mesenchymal tissue |
Cell-based therapy |
Magnetism |
SVZ/ hippocampus |
Neuropsychiatric disorders (major psychiatric
disorders, schizophrenia, epilepsy, neuropathic pain, amyotrophic lateral
sclerosis, progressive muscle atrophy, multiple sclerosis); Neurodegenerative diseases (Alzheimer’s disease,
Parkinson's disease, Huntington’s disease); Stroke |
Ultrasound |
Hippocampus |
Major depression disorder; Alzheimer’s disease |
Abbreviations: Muse,
multilineage-differentiating stress-enduing cells; HVC, high vocal center;
SVZ, subventricular zone |