Patient

DSAs

Pre TPE

Post - TPE

DSA Trend

Days 1-14

Days 14-28

Days 28-55

Days 56-82

1

Day 8

Day 16

Day 31

Class I -Decreased level of A2 and disappearance of A3, B57.

Class I:

Class I:

Class I:

Class I:

Class II - Disappearance of DQA1, new weak DQ6.

A2 (M)

A2 (W)

A2 (W)

A2 (W)

A3 (W)

B57 (W)

B57 (W)

Class II: DQA1^*01:03 (S)

Class II:

Class II:

Class II:

DQA1^*01:01 (M)

DQ6 (M)

DQ6 (M)

DQ6 (W)

DQA1^*01:02 (M)

DQA1^*02:01 (W)

2

Day 6

Day 20

Day 28

Class I – Disappearance of A30, new weak CW6 and CW17.

Class I:

Class I:

Class I:

Class I:

Class II – Disappearance of DR7, new DQ7 and DQ9.

A30 (M)

A30 (W)

A30 (W)

CW6 (W)

B57 (W)

B57 (W)

CW17 (W)

CW6 (W)

CW6 (W)

CW17 (W)

CW17 (W)

Class II

Class II:

Class II:

Class II:

DR7 (M)

DR7 (W)

DR7 (W)

DQ7 (M)

DQ7 (S)

DQ7 (S)

DQ9 (M)

DQ9 (M)

DQ9 (M)

3

Day 5

Day 40

Day 71

Class I – Disappearance of B58.

Class I:

Class I:

Class I:

Class I:

Class II – Disappearance of DQ2 and DQA1^*05.

B58 (M)

B58 (W)

No DSA

No DSA

Class II:

Class II:

Class II:

Class II:

DQ2(S)

DQ2(M)

No DSA

No DSA

DQA1^*05 (S)

DQA1^*05 (M)

4

Day 7

Day 15

Day 30

Class I – Decreased levels of A2, A68, B57. Disappearance of CW8.

Class I:

Class I:

Class I:

Class I:

Class II - New DQ2 and DR53. DR53 disappeared on follow up.

A2 (S)

A2 (S)

A2 (M)

A2 (M)

A68 (M)

A68 (L)

A68 (L)

A68 (L)

B57 (L)

B57 (M)

B57 (L)

B57 (VL)

CW8 (L)

CW8 (L)

CW8 (L)

Class II: No DSAs

Class II:

Class II:

Class II:

DR53 (L)

DQ2 (L)

DQ2 (L)

DQ2 (VL)

5

Day 1

Class I – No change.

Class I:

Class I:

Class II – No change.

A2 (S)

A2 (S)

B8 (L)

B8 (L)

Class II:

Class II:

DR53 (S)

DR53 (S)

DQ8 (S)

DQ8 (S)

DR4 (S)

DR4 (S)

DQ2 (M)

DQ2 (M)

6

Day 8

Day 16

Day 42

Day 80

Class I - Not applicable.

Class I:

Class I:

Class I:

Class I:

Class I:

Class II - Decrease in level of DPB1^*04:02. Disappearance of DR52 and DR13.

No DSAs

No DSAs

No DSAs

No DSAs

No DSAs

Class II:

Class II:

Class II:

Class II:

Class II:

DQ7 (S)

DQ7 (S)

DQ7 (S)

DQ7 (S)

DQ7 (S)

DR13 (S)

DR13 (W)

DR13 (W)

DR13 (W)

DPB1^*04:02 (W)

DR52 (M)

DPB1^*04:02 (W)

DPB1^*04:02 (W)

DPB1^*04:02 (M)