Table 1: Potential drug classes for therapy in PIH/placental dysfunction.
Drug Class | Potential mechanism | Class members | Pregnancy class |
Nitrate donors | NO diffusion | Arginine, nitrates | B |
PDE-5 blockers | Increased local NO production | Tadafil, sildenafil, numerous others | B except sildenafil C |
Prostacyclin receptor agonists | Reduced vasoconstriction | Iloprost, beraprost | B iloprost beraprost unrated |
Endothelin receptor blockers | Reduced vasoconstriction improved endothelial function | Sitaxentan, zilosentan numerous others | unrated |