Treatment Outcome

AL (N total = 72)

ASMF (N total = 72)

DHAP (N total = 72)

Fever clearance Time (hours)

12.57 h ± 3.50

11.25 h ± 5.11

11.02 h ± 2.33

Parasite Clearance time (hours) SD (CI95%)

34.3 ± 18.4 (3.2-8.1; P = 0.0001)

39.7 ± 21.4 (7.3-14.7; P = 0.0001)

28.7 ± 9.64 (3.2-8.1; P = 0.0001)

Positive blood film at D1 (N (%))

18 (25)

21 (29.2)

14 (19.4)

Positive blood film at D2 (N (%))

11 (15.3)

13 (18.0)

11 (15.3)

Positive blood film at D3 (N (%))

2 (2.8)

1 (1.4)

0

Withdrawal/loss to follow-up (D1-D7)

0

0

0

Withdrawal/loss to follow-up (D7-14)

2

0

0

LTF (D7-14)

0

0

0

Analysed at D14

70

72

72

aAdequate clinical and Parasitological Response (ACPR) Day 14 (N,%)

70 (100)

72 (100 )

72 (100 )

Analysed at D28

69

70

70

Withdrawal/loss to follow up

1

2

2

LTF (D15-28)

2

4

1

Late parasitological failure (LPF) (N/total, %)

7

3

4

aAdequate clinical and Parasitological Response (ACPR) Day 28 (N, %)

60 (86.9) (IC95%; 85.3-88.5%)

63 (90.0) (IC95%; 88.8-91.2%)

65 (92.9) (IC95%; 92.1-93.7%)

Analysed at D42

69

68

70

Withdrawal/loss to follow-up

0

0

0

Late treatment failure on day 42

4

0

1

Late parasitological failure (LPF) (N/total, %)

9

11

5

aAdequate clinical and Parasitological Response (ACPR) Day 42 (N/total, %)

56 (81.1) (IC95% 78.8-83.4%)

57 (83.8) (IC95%; 81.8-85.8%)

63 (91.3) (IC95%; 90.3-92.3%)