Clinical Criteria

Interpretation

References

1

Tumor size

Size > 10 cm correlates with higher RM.

[46,66]

2

Surgical margins

Positive margins correlate with LR.

[64]

Resectability

It is one of the most reliable prognostic factor

[58,64]

3

4

Cartilage and bone erosion or infiltration

Associated with infiltrative margins and high grade at histology. On images, it correlates with aggressive behavior and poor clinical outcome.

[47]

Histologic Criteria

Interpretation

References

1

^#Cellularity

Hypocellular lesions usually behave benignly

^#arbitrary criterion, according to some authors.

[12,57]

2

Tumor cells atypia

Usually mild or absent in benign lesions

[47,57]

3

Mitotic rate

> 4/10HPF correlates with RM, DOD.

[46,57]

4

Tumor necrosis

Correlates with aggressiveness and poor clinical outcome

[57]

5

Anaplastic/sarcomatoid/ dedifferentiated foci

Correlates with higher rate of LR, RM, DOD

[50]

6

Infiltrative margins

Correlate with risk of positive margins and LR

[47]