Poormoghim H (2019) Foot Pain and Lesions in Systemic Sclerosis: Prevalence and Association with Organ Involvement. J Rheum Dis Treat 5:075.


© 2019 Poormoghim H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESS DOI: 10.23937/2469-5726/1510076

Foot Pain and Lesions in Systemic Sclerosis: Prevalence and Association with Organ Involvement

Hadi Poormoghim1*, Elham Andalib1, Arash Jalali2, Maryam Salimi-beni1 and Gholam Hossein Ghafarpour1

1Iran University of Medical Sciences, Firoozgar Hospital, Iran

2Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Iran



Our goal was to evaluate prevalence of foot pain and lesions in patients with systemic sclerosis (SSc) and their association with other organ involvements.

Materials and methods

In this cross-section study 133 scleroderma patients were probed throughout a survey in which both forms of digital and non-digital plantar lesions were included. Chi-square test and student's t-test were used to determine the associations of foot pain and lesion with clinical features and serologic findings of the disease. multivariate analysis was used for determining independent factors associated with foot lesion and pain.


Of all patients, 119 (89%) were women with a mean age +Standard Deviation (SD) of 39.3 + 13.1 years, 32 (24.1%) patients had foot pain, and 40.6% were classified as having diffuse cutaneous SSc. Mean disease duration was 6.7 ± 5.8 years. Foot lesions were found in 47 (35%) of patients; from which 30 (93.8%) patients reported foot pain. In univariate analysis, Foot lesion were associated with vascular lesion, such as Raynaud 's phenomenon on the foot (p < 0.001), digital ulcer/gangrene (p < 0.005), calcinosis (p < 0.00 1), and high pulmonary arterial pressure on echocardiography (PAP), (p < 0.05). Additionally, we noticed the association of foot lesion with inflammatory disease, such as arthritis (p < 0.001), tendon friction rub (p < 0.004), pericardial effusion (p < 0.003), and esophageal dysmotility (p < 0.03) for vascular foot lesion. In the multivariate model, the diffuse subtype of the disease, presence of telangiectasia, calcinosis and Raynaud's on foot showed a significant association with vascular foot lesion.


Foot pain and lesion are common in Scleroderma patients, the diffuse subtype of the diseases, foot's Raynaud's, calcinosis, and telangiectasia were independently associated factors with foot lesion.