Patient 1

Patient 2

Patient 3

Age (y)

30

57

38

Gender

Male

Male

Male

Presenting symptoms

Severe headache for 3 days, LOC

Hypertensive bout, Acute right-side motor deficit, Broca’s aphasia, Agitation, LOC

Headache, Nausea, Vomiting, Altered consciousness, Agitation, seizures

Fever on admission

No

No (hypothermia)

No

Presence of seizures

No

No

Yes, Generalized

Initial GCS

4 (M2 V1 O1)

Sedated

13 (M6 V4 O3)

Pupils on admission

Fixed, Mydriatic

Myotic (sedation)

Reactive, Isochoric

Ventilated on arrival

Yes

Yes

No

Brain CT findings (admission)

Intraparenchymal hematoma, No vascular anomaly, Involvement of all ventricles, Secondary SAH

Intraparenchymal hematoma, No vascular anomaly, Involvement of all ventricles

Pretruncal nonaneurysmal SAH, Involvement of 4^th ventricle

Type and Location of ICH

Right thalamic, Panventricular extension,

Right sylvian SAH

Left thalamic, Panventricular extension

Pretruncal SAH, 4^th ventricle extension

Initial lung CT findings

Ground glass opacities in the inferior right lobe, Thin pleural fluid collection bilaterally

Ground glass opacities affecting both lungs, Bilateral fluid collection approx. 1 cm thick

Ground glass opacities in the lower lobes

COVID-19 PCR positivity date

24.11.2020

09.11.2020

30.11.2020

Days intubated

6

20

7 (interrupted)

Anticoagulant/antiplatelet (after admission)

No

Fraxiparine

Fraxiparine

clexane

Intervention for ICH

Right EVD

Right EVD

Right EVD

Concomitant infections

None detected

None detected

Pulmonary

CSF pressure and Aspect (surgery)

Increased pressure, Blood red

Increased pressure, Blood red

Increased pressure, Slightly tinted red

Lab Findings on Admission (measure units)

WBC (10⁹/L)

19.52 (4-10)

13.54 (4-10)

16.68 (4-10)

RBC (10¹²/L)

5.78 (4.5-5.5)

5.31

4.82

HGB (g/dL)

16.5

15.7

14.3

HCT (%)

49.9

48.8

42.6

MCV (fL)

86.3

92.0

88.4

MCH (pg)

28.5

29.7

29.6

MCHC (g/dL)

33.0

32.2

33.4

RDW-SD (fL)

40.9

41.5

41.0

RDW-CV (%)

13.7

13.0

13.1

PLT (10⁹/L)

375

175

253

PDW (fL)

15.9

16.3 (10.1-16.1)

15.7

MPV (fL)

9.3

11.7

9.3

PCT (%)

0.351% (0.17-0.32%)

0.204%

0.237%

P-LCR (%)

21.0%

36.6%

20.2%

NEUT%

83.8% (30-75%)

81.5% (30-75%)

85.9% (30-75%)

NEUT# (10⁹/L)

16.35 (1.5-6.6)

11.03 (1.5-6.6)

16.04 (1.5-6.6)

LYMPH%

8.6% (20-45%)

11.0% (20-45%)

5.9% (10-45%)

LYMPH#

1.68

1.49

1.10

MONO%

7.6%

7.4%

8.0%

MONO#

1.48 (0.21-0.92)

1.01 (0.21-0.92)

1.50 (0.21-0.92)

EO%

0.0% (1-5%)

0.0% (1-5%)

0.1 (1-5%)

EO#

0.00 (0.02-0.67)

0.00 (0.02-0.67)

0.02

BASO%

0.0

0.1%

0.1%

BASO#

0.01

0.01

0.02

ALAT

45

24

26

ASAT

29

25

19

Direct bilirubin

0.06

0.15

0.20

Total bilirubin

0.32

0.79

0.89

Ionized calcium (mg/dL)

4.38 (4.4-5.4)

4.62

4.47

Total calcium (mg/dL)

8.77 (8.8-10.6)

9.02

8.52 (8.8-10.6)

Creatin kinase (U/L)

226 (< 171)

165

350 (< 171)

CK-MB (U/L)

29 (< 24)

13

9

Creatinine (mg/dL)

0.93

2.24 (0.67-1.17)

0.61 (0.67-1.17)

Alkaline phosphatase

76

62

71

GGT (U/L)

28

38

22

Glycemia (mg/dL)

174 (74-106)

122 (74-106)

96

Sodium [Na] (mmol/L)

138

141

142

Potassium [K] (mmol/L)

4.47

4.39

3.47 (3.5-5.1)

Chloride [Cl] (mmol/L)

105

105

106

LDH (U/L)

231

214

N/A

C-reactive Protein (mg/dL)

0.34

1.17 (< 0.5)

10.77 (< 0.5)

Urea (mg/dL)

30

64 (17-43)

24

APTT (sec.)

21.3

21.7

20.8

PT (sec.)

12.8

12.8

16.2 (10.5-15)

Prothrombin index (%)

89.1

89.1

70.6 (80-120)

INR

1.12

1.12

1.34 (0.8-1.22)

Outcome

Deceased

Deceased

Alive (in ICU)