Oxidative stress (OS) could be involved during intracranial aneurysms (ICA) progression but knowledge about comorbidities likely to induce OS is poor. We studied the medical and surgical history of patients with an ICA discovered after a subarachnoidal haemorrhage (SAH) or unruptured (UIA).
175 patients, 58 with a UIA, had been successively recruited from a single centre. Their medical history, comorbidities and treatments had been gathered from hospital files, general practitioners, relatives and patients. Frequency of each diseases had been compared between UIA and SAH groups and to the French population prevalence (FPP) issued from national organisations.
A "significant" medical or surgical history was absent in 14% of patients. Withdrawn smokers were more frequent in the UIA group. Dyslipidaemias, diabetes, were more frequent (p < 0.05) in the SAH group than FPP. High blood pressure, other cardiovascular diseases were not higher than FPP. Migraines and psychiatric disorders, hypothyroidism, cancers and benign tumours were significantly elevated. Twelve orphan diseases were diagnosed, most of them involving connective tissue disorders, others being of unknown origin. Twenty five percent of women had a heavy gynaecological history. A surgical history was more frequent in the UIA group. NSAID, aspirin, antidepressants were found prescribed in a higher proportion than the FPP.
Central nervous system diseases, orphan diseases and tumours are abnormally more frequent in this cohort as compared to the FPP likely to induce a significant oxidative stress-related systemic impairment. Further studies are required to check whether ICA without noticeable comorbidities could be predominantly familial and represent a particular entity.