Clinical Medical

Reviews and Case ReportsISSN: 2378-3656

Current Issue

 Open Access DOI:10.23937/2378-3656/1410388

A Double-Edged Sword - Multiorgan Dysfunction as a Rare Complication of Dual Checkpoint Immunotherapy

Matthew Boykow, Ami K Patel1, Neil Sondhi, Eli Wercberger, Asif Mohammed, Devarajan Iyengar, Antonios Tsompanidis and John Dedousis

Article Type: Case Report | First Published: March 31, 2022

There are many immune checkpoints in the body which serve different functions. Some Immune checkpoints are molecules involved in the maintenance of immunologic homeostasis, and therefore help to maintain peripheral tolerance to self-molecules. Other immune checkpoints such as CTLA-4 and PD- 1, are important for augmenting or inhibiting the immune response. Yervoy (Ipilimumab) and Opdivo (Nivolumab) are monoclonal antibodies developed to target CTLA-4 and PD-1 respectively to augment the immune s...

 Open Access DOI:10.23937/2378-3656/1410387

A Spontaneous Tracheal Breach and a Pneumomediastinum in an 18-Month-Old Child: An Extremely Rare Case Report

Othmane Benhoummad, Sara Rochd, Zineb Sarda, Youssef Rochdi and Abdelaziz Raji

Article Type: Case Report | First Published: March 31, 2022

Spontaneous pneumomediastinum (SPM) in children was first defined by Hamman in 1939, Its Association to a posterior tracheal tear is even more uncommon. We report the case of an 18-month-child that presented a SPM associated to a posterior tracheal tear. The patient had no medical history and presented two days before her admission a dry cough and a shortness of breath. The radiological investigation showed a pneumomediastinum with an extensive subcutaneous emphysema and a posterior tear in the ...

 Open Access DOI:10.23937/2378-3656/1410378

One Head Trauma, Three ENT Manifestations

Pedro Santos, MD, Ângela Rego, MD, Isabel Carvalho, MD and Luís Meireles, MD

Article Type: Case Report | First Published: December 31, 2021

It is well known that head trauma (HT) can cause hypoacusis; as well as benign positional paroxysmal vertigo (BPPV) and anosmia, which are frequently referred as sequelae of HY. However, the post-HT triad of BPPV, hypoacusis and anosmia is extremely rare to occur in the same patient, with only two cases reported in the literature. With this case report we wish to describe a clinical case of HT that caused hypoacusis, BPPV and anosmia as sequelae, and to review the importance of ENT evaluation in...

 Open Access DOI:10.23937/2378-3656/1410377

Acute Limb Ischemia as an Unusual Presentation of Spontaneous Coronary Artery Dissection

Basel Musmar and Alaa Gabi

Article Type: Case Report | First Published: December 31, 2021

Spontaneous coronary artery dissection (SCAD) is a rare, though, important cause of acute coronary syndrome that is more commonly seen in young and middle-aged women without risk factors for, or a history of, coronary artery disease. Acute embolization of left ventricular (LV) thrombus is an uncommon but known cause of acute limb ischemia. In this case, we present a rare case of SCAD that led to acute limb ischemia due to embolization of LV thrombus. A 53-year-old female with a past medical his...

 Open Access DOI:10.23937/2378-3656/1410376

Bilateral Lung Transplantation Due to Sjögren’s Syndrome in a Patient with Klinefelter Syndrome

Beauperthuy Levy Thais, MD, Anguera de Francisco Gabriel, MD, Fonfría Esparcia Carles, MD and Mancheño Franch N, MD

Article Type: Case Report | First Published: December 24, 2021

Klinefelter syndrome is one of the most frequent congenital chromosome disorders. Autoimmune diseases are not uncommon in patients with Klinefelter syndrome and associations between them have long been described. However, there is a paucity of literature regarding the effect of hypogonadism on respiratory system in these patients. Herein, we described a 28-year-old patient who presented with a constellation of unexplained respiratory signs and symptoms, such as tachypnea, hypoxemia, crackles rec...

 Open Access DOI:10.23937/2378-3656/1410375

An Unusual Complication of Mesenteric-Portal Axis Thrombosis and Septic Shock in a Patient with Mesangial Proliferative Glomerulonephritis

Sicharam Vijaya Luxmi, Sun Yue, Chen Xing Qing, Cao Fang Fang, Swalay Fedally and Du Xiao Gang

Article Type: Case Report | First Published: December 18, 2021

Thromboembolic events contribute to the most serious outcomes in patients with nephrotic syndrome. We report a case of a young male patient with mesangial proliferative glomerulonephritis presenting with nephrotic syndrome, which rapidly progressed to mesenteric and portal veins thrombosis and septic shock, ultimately leading to death. A 19-years-old, male patient was admitted due to bilateral lower extremity edema and abdominal distension. The abdominal distension appeared 2 months ago with acc...

Volume 8
Issue 12