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International Journal of

Clinical Biostatistics and BiometricsISSN: 2469-5831

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 Open Access DOI:10.23937/2469-5831/1510052

Statistical Analysis in Clinical Trials Using the Study Data Tabulation Model (SDTM) and the Analysis Dataset Model (ADaM): Effects, Obstacles, and Solutions

Sagar Kumar Patel, Srinivasa Reddy Mukkala, Rachna Patel and Sandeep Bolla

Article Type: Review Article | First Published: 2023/09/25

Proper statistical analysis is the most important thing in clinical trials if a person wants to come to accurate conclusions and make smart decisions about the safety and effectiveness of new medical interventions. The utilization of the Study Data Tabulation Model (SDTM) and the Analysis Dataset Model (ADaM) is imperative in facilitating this process. The Study Data Tabulation Model (SDTM) is a universally accepted and standardized framework utilized to structure and display data obtained from ...

 Open Access DOI:10.23937/2469-5831/1510042

The Modeling by Fuzzy Least Squares Regression Approach Relationships between Copper Values in the Soil, Vegetables, Fruits and Human Tissue

Derviş Topuz and Kenan Kiliç

Article Type: Research Article | First Published: September 06, 2021

The aim of this study is to determine whether the potential toxic copper element values measured in soils (X1), vegetables (X2) and waters (X3) have an effect on the copper elements in the stomach and intestinal tissue (Yi) (ppm) of individuals in an area of approximately 2400 km2 covering the east of Erciyes strato volcano. We applied Diamond’s fuzzy least squares (FLS) method, which assumes that the deviation between the observed and the predicted values is due to the fuzziness of the coeffi...

 Open Access DOI:10.23937/2469-5831/1510041

Determination of Factors Influencing the Activities of PR Interval on the Electrocardiogram (ECG) in an Experiment of the Factorial Type

Adisa Jamiu SAKA

Article Type: Medical Statistics | First Published: August 16, 2021

Human heart is a strong muscle that pumps blood to the body. A normal, healthy adult heart is about the size of human clenched fist and it is like an engine that makes a car works, moves and functions properly as such, the heart keeps the body running. A healthy heart supplies the body with just the right amount of blood at the right rate for whatever the body is doing at that time. The flow of blood to the heart could be reduced by plaque build-up or blockage by a plaque suddenly ruptures, thes...

 Open Access DOI:10.23937/2469-5831/1510040

Efficacy and Safety of Rilpivirine-Based Antiretroviral Therapy in Treatment-Naïve and Treatment-Experienced HIV-1- Positive Patients: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Lazzarin A, Rusconi S, Antinori A, Galeone C, Uglietti A, Termini R and Mancusi D

Article Type: Meta-Analysis | First Published: August 16, 2021

Rilpivirine (RPV) is a second-generation non-nucleoside reverse-transcriptase inhibitor used in combination antiretroviral therapy (cART) in naive and experienced HIV-positive adult subjects. To evaluate its efficacy and safety in these patient settings, we performed a metaanalysis of randomized controlled trials with available data at 48 and 96 weeks of follow-up. We considered 4 studies involving 2336 cART-naïve patients and 8 studies involving 3165 cART-experienced virologically controlled p...

 Open Access DOI:10.23937/2469-5831/1510039

Modeling the Risk Assessment of COVID-19 Pandemic in Bingham University of Nigeria

Emmanuel Azuaba, Bimba John Samson, Edwin Ehi Eseigbe, Tamber Jighjigh Abraham, Yusuf Musa, Akude Christian, Isah Omeiza Haroun and Oniore Jonathan Ojarikre

Article Type: Original Research | First Published: July 28, 2021

COVID-19 virus has spread everywhere in Africa and to the 36 states of Nigeria, including the Federal Capital Territory (FCT), Abuja. The outbreak of COVID-19 in Lagos, since February 27, 2020 has generated 158,506 confirmed cases, including 1,969 deaths, as of 8 March 2021. In most cases, community transmission is the prime factor in which the viruses are fast spreading. Fortunately, there has never been a reported incidence of COVID-19 infection on any of the Nigerian university campuses. We a...

Volume 7
Issue 2