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International Journal of

Brain Disorders and TreatmentISSN: 2469-5866

Early Online

 Open Access DOI:10.23937/2469-5866/1410052

Harnessing Magnetic Resonance-Guided Focused Ultrasound for Precise Blood-Brain Barrier Disruption: Advancements in Targeted Therapeutics for Neurological Disorders

Mohammadreza Tahriri

Article Type: Review Article | First Published: 2024/09/28

This review examines the latest advancements in the clinical application of Magnetic Resonance-guided Focused Ultrasound (MRgFUS), also referred to as Magnetic Resonance High-Intensity Focused Ultrasound (MR-HIFUS), for transiently permeabilizing the blood-brain barrier (BBB), thereby enhancing drug delivery for neurological disorders treatments. Extensive preclinical studies and human safety trials have established a robust safety profile for MRgFUS, supporting its use in conditions such as Alz...

 Open Access DOI:10.23937/2469-5866/1410051

Rare Intrasellar Space Occupying Lesion Presenting as Hypopituitarism: Case Report and Review of the Literature on Intrasellar Arachnoid Cyst

Parul Gupta

Article Type: Case Report | First Published: 2024/09/18

Compared to cystic adenomas, craniopharyngiomas, and Rathke's cleft cysts, intrasellar arachnoid cysts are rare. The differential of intrasellar Arachnoid Cysts should be regarded in patients with radiologically confirmed intrasellar cystic lesions....

 Open Access DOI:10.23937/2469-5866/1410050

Recurrent Desmoplastic Infantile Ganglioglioma Treated with Antineoplastons: Partial Response and Overall Survival of > 11.8 Years in a Ten-Month-Old Female

Stanislaw R. Burzynski, Gregory S. Burzynski, Tomasz Janicki Alejandro Marquis and Samuel Beenken

Article Type: Case Report | First Published: 2024/07/21

Desmoplastic infantile tumors (DIT) are rare neoplasms of the central nervous system that occur in infants and young children. According to the World Health Organization (WHO) grading system, DIT are classified into three subtypes: Desmoplastic infantile astrocytoma (DIA), desmoplastic infantile ganglioglioma (DIG), and desmoplastic/nodular medulloblastoma (DNMB). DIA and DIG are WHO grade 1 while DNMB is WHO grade 4. Recurrent WHO grade 1 DIT have a very poor prognosis and there is no standardi...

 Open Access DOI:10.23937/2469-5866/1410049

Investigation on the Relationship between Metabolic Changes and Symptom Burden in Sport-Related Concussion Recovery

Allyn Abadie, José R Fernández and Ryan N Moran

Article Type: Original Research | First Published: 2024/05/17

A sport-related concussion (SRC) is a mild traumatic brain injury resulting from impulsive forces in sports, often presenting various symptoms. Clinicians lack objective measures and rely on subjective patient reports (via symptom checklists or inventories) to guide return-to-play decisions. These methods, however, may not reflect physiologic recovery, with concern over the under-reporting of symptoms to return to activity quicker. Quantitative tracking of physiologic recovery could offer a more...

 Open Access DOI:10.23937/2469-5866/1410048

Cystic Vestibular Schwannomas: Clinical and Therapeutic Particularities

Lotfi Boublata, Oumaima Bouzerara, Imene Lekikot, Ahlem Laouar, Belkacem Boudjaja and Soumeya Amarouche

Article Type: Original Article | First Published: 2024/02/19

The tumor volume and the quality of the tumor resection were evaluated by MRI according to the Kenzaki classification. The facial nerve function was evaluated according to the House and Brackmann classification. The type of the cystic SV according to the position of the cyst and the thickness of the cystic wall was classified into type A and B according to the Piccirillo, et al. classification (PC)....

 Open Access DOI:10.23937/2469-5866/1410047

How Necessary is Duraplasty in the Treatment of Chiari Malformation?

Mahmut CAMLAR, Mustafa Eren YUNCU, Ali KARADAG, Merve OREN, Caglar TURK, Ozgur OZTEKİN and Fusun OZER

Article Type: Original Research | First Published: 2024/02/08

In this study, 46 patients who were operated on for Type I Chiari malformation (CM) in our clinic since 2010 were included. The preoperative and postoperative cranial and spinal MRI examinations of all patients were compared between the two groups in terms of hydrocephalus, tonsillar herniation level, the presence and level of syringomyelia, osseous anomalies, postoperative cisterna magna formation, postoperative obex structure, and syringomyelia status....

 Open Access DOI:10.23937/2469-5866/1410046

Serum Glial Fibrillary Acidic Protein (GFAP) Levels Are Higher in Individuals Taking Selective Serotonin Reuptake Inhibitors (SSRIs)

Mary Jo Kurth, Joanne Watt, Paul Innocenzi, Laura Mooney, John V. Lamont, Peter Fitzgerald and Mark W Ruddock

Article Type: Research Article | First Published: 2024/01/11

PTSD is a mental health condition that can develop in some individuals who have experienced or witnessed a traumatic or life-threatening event. Previously, we identified a combination of blood biomarkers to differentiate controls from a PTSD cohort. This biomarker model could be used to diagnose and monitor treatment of PTSD, both behavioural and pharmacological. ...

 Open Access DOI:10.23937/2469-5866/1410043

Spreading of Trigeminal Neuralgia and Hemifacial Spasm to Blepharospasm: What the Role for Neurovascular Compression of the Vth Cranial Nerve?

Sergio Altomare, Maria Stella Aniello, Ruggiero Leone and Maurizio Giorelli

Article Type: Case Report | First Published: June 30, 2022

Blepharospasm (BB) in an involuntary movement disorder characterized by stereotyped, bilateral, and synchronous spasms of the orbicularis oculi (OO) muscles. Spasms may be either brief or sustained and give rise either to narrowing or spasmodic closure of eyelids thus leading to functional blindness....

 Open Access DOI:10.23937/2469-5866/1410042

Juvenile Stroke in a Patient with Severe Large Vessel Atherosclerosis of the Neck Decades after Radiotherapy for Nasopharyngeal Carcinoma: Are Iatrogenic Endocrinopathies Additional Risk Factors?

Ruggiero Leone, Sergio Altomare, Maria Stella Aniello, Daniele Liuzzi, Immacolata Plasmati, Michele Sardaro, Maria Superbo, Daniela Tato, Rosella Carpentiere, Giuseppe Guglielmi and Maurizio Giorelli

Article Type: Case Report | First Published: June 20, 2022

Juvenile Nasopharyngeal carcinoma (NPC) is a rare head and neck cancer in Western Countries. Neck radiotherapy (RT) is a routine procedure for treating or preventing the nodal metastasis in NPC patients. Ionizing radiation from RT has been associated with enhanced atherosclerotic process of large vessel arteries of the neck and brain which results in higher incidence of cerebrovascular events....

 Open Access DOI:10.23937/2469-5866/1410041

Magnetic Particles in the Human Body: A Short Review on the Effects of these Particles on the Human Health

Manfred Fähnle

Article Type: Review Article | First Published: January 08, 2022

Magnetic particles in the human body have various effects on the human health, ranging from positive effects in the treatment of diseases, e.g., by a hyperthermia treatment, to negative effects, e.g., on Alzheimer’s disease. In the present manuscript a short review is given on these effects of magnetic particles in the human body. It is written that by exposing diseased tissue to elevated temperature for a period of time, called hyperthermia, is a promising treatment of human diseases. Cells a...

Volume 8
Issue 1