Uric Acid as a Novel Component of Metabolic Syndrome
Rodney G Bowden, PhD, Kathleen A Richardson, PhD and Luke T Richardson, PhD
Article Type: Original Research | First Published: 2023/06/30
A cross-sectional data analysis was conducted using the 2013-2018 NHANES datasets. Sample weights were assigned by NHANES researchers to each participant allowing researchers to generalize results to all non-institutionalized US civilians. The analysis included 6,432 individuals, which were representative of 94,729,059 US citizens....
Effect of Edoxaban, F-Xa-Directed Oral Anticoagulant on Spontaneous Thrombolytic Activity in Apoe-/- and Ldlr-/- Double Knockout Mice
Kanae Hyodo, MS, Naotaka Ohta, PhD, Hiromitsu Ishii, MD and Tsutomu Yamashita, PhD*
Article Type: Original Article | First Published: December 01, 2022
The details of thrombolytic activity in occlusive disease associated with atherosclerotic lesions are not clear. This study investigated the novel effects of activated coagulation factor X (F-Xa)-directed oral anticoagulant (DOAC) edoxaban on in vivo thrombolytic activity and atherosclerosis progression. Mice were fed an experimental diet (edoxaban 15-50 mg/kg) for 18 weeks. The degree of progression of atherosclerosis was assessed as the area of atherosclerotic vessels as a percentage of the to...
siRNA-Induced Silencing of LP(a) Gene: An Ideal Choice to Prevent Genetic Risk of Myocardial Infarction
Article Type: Review Article | First Published: November 18, 2022
Elevated level of lipoprotein (a) gene is the main cause of inherited risk of myocardial infarction (MI). Several RNA based therapies are being developed to reduce the expression of LP(a) gene, but none of them are neither available in market, nor have been declared as perfect choice for treatment. An American multinational biopharmaceutical company, Amgen Inc, has recently disclosed remarkable test results of phase II trial of Olpasiran [a small interfering RNA-based (siRNA) therapy to target L...
Multimodality Imaging Applied to Dilated Cardiomyopathy
João Baltazar Ferreira, Marco Beringuilho, Inês Fialho, Mariana Passos, Joana Lopes and Carlos Morais
Article Type: Review Article | First Published: October 03, 2022
Dilated cardiomyopathy is a heterogeneous group of diseases, in which imaging modalities are important for diagnosis, guiding therapy and prognostic assessment. Given the plethora of imaging techniques available, each one with its strengths and limitations, it is of crucial importance to appropriately select which ones to use based on the clinical context....
Single-Access Technique and Manta Device in Acute Myocardial Infarction Related Cardiogenic Shock
Andrea Bezzeccheri, MD, Antonietta Di Iorio, MD, Mario Scarpelli, MD and Carlo Briguori, MD, PhD, FACC, FSCAI
Article Type: Case Report | First Published: October 02, 2022
Cardiogenic shock (CS) occurs up to 10% of patients with acute myocardial infarction (AMI) and is associated with a high (> 50%) in-hospital mortality. Mechanical circulatory support (MCS) devices, such as Impella CP, are increasingly being used in patients with AMI complicated by CS. Recent data highlighted the issue of vascular complication and bleeding events in cardiogenic shock patients treated with Impella. In this setting, the “Single-access for High-risk PCI” (SHiP) technique and the...
Atrial Flow Regulator: A New Player for the Treatment of Refractory Heart Failure
Vincenzo Rizza, MD, Giuseppe Uccello, MD, Francesco Federico, MD, Mariano Pellicano, MD, PhD, Maurizio Tespili, MD and Alfonso Ielasi, MD
Article Type: Case Report | First Published: July 23, 2022
Described herein the case of a 55-year-old man diagnosed with advanced heart failure. He had a history of ischemic heart disease leading to moderate left ventricular systolic disfunction, symptomatic for effort dyspnoea despite optimal medical therapy. After coronary angiography and right heart catheterization (showing basal pulmonary capillary wedge pressures - PCWP - 20 mmHg), the patient underwent percutaneous inter-atrial shunt therapy (IAST) through the opposition of an Atrial Flow Regulato...
In-Hospital Cardiac Manifestations of COVID-19 Pneumonia and their Management
Rajkumar Gangappa Nadakinamani, Prashanth Panduranga, Mohammed Aziz Khandekar, James Pallivathukkal and Baher Youssef Hanna
Article Type: Review Article | First Published: July 09, 2022
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 has been declared a pandemic. Broadly, hospitalized COVID-19 pneumonia patients suffer two important cardiac effects. Firstly, when COVID-19 pneumonia affects people with pre-existing cardiovascular disease (CVD), they have worst outcomes compared to those without CVD....
Sudden Cardiac Arrest in Patient with Aortic Stenosis and Preexcitation
Vikas Kalra, MD and Krittapoom Akrawinthawong, MD
Article Type: Case Report | First Published: June 23, 2022
58-year-old male sustained sudden cardiac arrest (SCA) due to ventricular fibrillation (VF) while at work and was resuscitated with shock therapy. He had prior history of coronary artery disease with bypass, preexcitation, pulmonary hypertension, hyperlipidemia, Hodgkin's disease, hypothyroidism and squamous cell carcinoma....
Awareness of Smoking Cessation Aids in Heart Disease Patients at Governmental Hospitals
Hanin Bogari, Raghad Althubaiti, Ghaidaa Garoot and Asmaa Ali
Article Type: Original research article | First Published: June 13, 2022
Over one million people are smoking worldwide and the total numbers is expected to increase each year. Several studies have shown a relation between smoking and heart problems, which highlight special consideration in smoking cessation awareness in heart disease patients with established vascular disease as a secondary prevention....
Recurrent Pericardial Effusion following Diaphragmatic Hernia Repair
Rony Shah, MD, Aakash Patel, MD, James Craig, MD, Hassan Baydoun, MD and Jeffrey Jordan, MD
Article Type: Case report | First Published: June 13, 2022
The pericardial space is defined as the cavity between the visceral and parietal pericardium and it normally contains 10-50 mL of fluid. A pericardial effusion exists when the intrapericardial volume exceeds these limits. Any process that causes inflammation, injury, or decreased lymphatic drainage can cause a pericardial effusion....
Coronary Artery Ectasia and Oral Anticoagulation: A Case Report
Shivum Desai, BS, Justin Dombrowski, BS and Joseph Klag, DO, FACC, FSCAI
Article Type: Case Report with Brief Literature Review | First Published: April 30, 2022
Coronary Artery Ectasia is a pathology effecting nearly 4.9% of the general population. This disease process can be found in any one of the coronary arteries and often presents in patients with comorbid conditions such as coronary artery atherosclerosis and hypertension. This combination of disease processes is often difficult to treat due to the lack of peer-reviewed data and treatment guidelines for coronary artery aneurysms. Additionally, there is currently no general consensus on the use of ...
Partially Resolving Myocardial Fibrosis Five Months Following the mRNA COVID-19 Vaccine: An MRI Based Case Report
AFM Ashik Imran, DO, MBBS, Won Jun Park, MD and Michael R Sood, MD, MS
Article Type: Case Report | First Published: April 27, 2022
Myocarditis is a disease that has varying degrees of clinical manifestations. Furthermore, its diagnosis and management can pose as a challenge to clinicians. With over 250 million people receiving the mRNA covid vaccine, there have been rare reports of myocarditis, pericarditis or other cardiovascular involvement. However, its natural course remains unclear. We report a 30-year-old healthy male who was hospitalized 3 days after the second dose of the covid-19 vaccination. He had high cardiac la...
STEMI during Cardiocerebral Infarction (CCI): Is it Safe to Perform Primary Percutaneous Coronary Intervention?
Thon Hon Yong, Jia Hao Jason See and Boon Wah Liew
Article Type: Case Series | First Published: April 14, 2022
Emergency percutaneous coronary intervention (PCI) is a critically important reperfusion strategy for myocardial salvage in the event of acute ST elevation myocardial infarction (STEMI). However, it poses great challenges to the treating cardiologist if there is a simultaneous acute cerebral infarction because of potential intracranial complications. Particularly, the use of dual antiplatelet and high dose anticoagulants during PCI has been well documented to increase the risk for cerebral hemor...
Enlarged Left Ventricular Diastolic Dimension does not Predict Irreversible Left Ventricular Systolic Function in Patients with Atrial Arrhythmia
Hisao Matsuda, Yui Nakayama, Airi Noda, Toru Nakanishi, Dan Koto, Mizuho Kasahara, Takayuki Warisawa, Kei Mizukoshi, Makoto Takano, Koichi Mizuno, Akira Kasagawa, Tarou Suchi, Daisuke Togashi, Ikutarou Nakajima, Kenichi Sasaki, Hidekazu Miyazaki, Toshiyuki Furukawa, Tomoo Harada and Yoshihiro J Akashi
Article Type: Original Article | First Published: April 20, 2022
Atrial arrhythmia (AA) and left ventricular systolic dysfunction (LVSD) frequently co-exist, and potentially represent growing public health problems. Determining whether tachycardia is an indicator or consequence of LVSD in patients with tachycardia and LVSD is difficult. Tachycardia-mediated cardiomyopathy (TCM) raises a “chicken or egg” question. Regardless of the etiology, patients with severe LVSD are considered candidates for the implantation of a cardioverter defibrillator as primary ...