International Journal of

Clinical CardiologyISSN: 2378-2951

Early Online

 Open Access DOI:10.23937/2378-2951/1410278

Uric Acid as a Novel Component of Metabolic Syndrome

Rodney G Bowden, PhD, Kathleen A Richardson, PhD and Luke T Richardson, PhD

Article Type: Original Research | First Published: 2023/06/30

A cross-sectional data analysis was conducted using the 2013-2018 NHANES datasets. Sample weights were assigned by NHANES researchers to each participant allowing researchers to generalize results to all non-institutionalized US civilians. The analysis included 6,432 individuals, which were representative of 94,729,059 US citizens....

 Open Access DOI:10.23937/2378-2951/1410274

Effects of Performance Enhancement Drugs on Body Mass Index, Blood Pressure, and Blood Sugar Levels on a Healthy Adult Male: A Case Study

Resti Tito H Villarino and Maureen Lorence F Villarino

Article Type: Original Article | First Published: April 12, 2023

Anabolic-androgenic steroids (AASs) are used as performance enhancement and are widely utilized among athletes and non-athletes worldwide. Although the risk-benefit ratio of using Performance Enhancing Drugs (PEDs) explicitly Anabolic-androgenic steroids are primarily published as systematic reviews and post-mortem case reports, there are limited reports on the effects of PEDs on body mass index, blood pressure, and blood sugar levels. ...

 Open Access DOI:10.23937/2378-2951/1410273

The Impact of Novel Active Fixation Left Ventricular Leads and Conventional Passive Fixation Leads in Cardiac Resynchronization Therapy

Makoto Takano, MD, Hisao Matsuda, Tomoo Harada and Yoshihiro J Akashi

Article Type: Original Article | First Published: January 27, 2023

Left ventricular (LV) leads are important devices for stimulating the most delayed site in cardiac resynchronization therapy (CRT). Since April 2020, the Attain Stability Quad (ASQ) lead, which has a side helix for facilitating active fixation, has become available in Japan. We evaluated the benefits of ASQ leads compared with those of conventional passive fixation LV leads....

 Open Access DOI:10.23937/2378-2951/1410272

Effect of Edoxaban, F-Xa-Directed Oral Anticoagulant on Spontaneous Thrombolytic Activity in Apoe-/- and Ldlr-/- Double Knockout Mice

Kanae Hyodo, MS, Naotaka Ohta, PhD, Hiromitsu Ishii, MD and Tsutomu Yamashita, PhD*

Article Type: Original Article | First Published: December 01, 2022

The details of thrombolytic activity in occlusive disease associated with atherosclerotic lesions are not clear. This study investigated the novel effects of activated coagulation factor X (F-Xa)-directed oral anticoagulant (DOAC) edoxaban on in vivo thrombolytic activity and atherosclerosis progression. Mice were fed an experimental diet (edoxaban 15-50 mg/kg) for 18 weeks. The degree of progression of atherosclerosis was assessed as the area of atherosclerotic vessels as a percentage of the to...

 Open Access DOI:10.23937/2378-2951/1410271

siRNA-Induced Silencing of LP(a) Gene: An Ideal Choice to Prevent Genetic Risk of Myocardial Infarction

Muhammad Arslan

Article Type: Review Article | First Published: November 18, 2022

Elevated level of lipoprotein (a) gene is the main cause of inherited risk of myocardial infarction (MI). Several RNA based therapies are being developed to reduce the expression of LP(a) gene, but none of them are neither available in market, nor have been declared as perfect choice for treatment. An American multinational biopharmaceutical company, Amgen Inc, has recently disclosed remarkable test results of phase II trial of Olpasiran [a small interfering RNA-based (siRNA) therapy to target L...

 Open Access DOI:10.23937/2378-2951/1410270

Unusual Cause of a Left Ventricular Mass in an Octogenarian with Metastatic Squamous Cell Lung Cancer

Steven J Grampp, Christopher D Manko, Pranjal Boruah and Stephen Voyce

Article Type: Case Report | First Published: November 03, 2022

A computed tomography scan of the chest in an 83-year- old male patient with a history of metastatic squamous cell lung cancer revealed a mass localized to the left ventricle. Subsequent imaging revealed this to be an incidental cardiac fibroma. Echocardiographic, computed tomography and cardiac magnetic resonance images and a review of the literature is presented....

 Open Access DOI:10.23937/2378-2951/1410269

Multimodality Imaging Applied to Dilated Cardiomyopathy

João Baltazar Ferreira, Marco Beringuilho, Inês Fialho, Mariana Passos, Joana Lopes and Carlos Morais

Article Type: Review Article | First Published: October 03, 2022

Dilated cardiomyopathy is a heterogeneous group of diseases, in which imaging modalities are important for diagnosis, guiding therapy and prognostic assessment. Given the plethora of imaging techniques available, each one with its strengths and limitations, it is of crucial importance to appropriately select which ones to use based on the clinical context....

 Open Access DOI:10.23937/2378-2951/1410268

Single-Access Technique and Manta Device in Acute Myocardial Infarction Related Cardiogenic Shock

Andrea Bezzeccheri, MD, Antonietta Di Iorio, MD, Mario Scarpelli, MD and Carlo Briguori, MD, PhD, FACC, FSCAI

Article Type: Case Report | First Published: October 02, 2022

Cardiogenic shock (CS) occurs up to 10% of patients with acute myocardial infarction (AMI) and is associated with a high (> 50%) in-hospital mortality. Mechanical circulatory support (MCS) devices, such as Impella CP, are increasingly being used in patients with AMI complicated by CS. Recent data highlighted the issue of vascular complication and bleeding events in cardiogenic shock patients treated with Impella. In this setting, the “Single-access for High-risk PCI” (SHiP) technique and the...

 Open Access DOI:10.23937/2378-2951/1410265

Innovations in Electrophysiology Technologies and Devices

Samir Rafla, Aly Aboelhoda and Amr Kamal

Article Type: Review article | First Published: August 03, 2022

There are major advances and achievements in devices used in electrophysiology diagnosis and treatment. This short summary is collection of recent publications around this subject....

 Open Access DOI:10.23937/2378-2951/1410264

Improvement in Hypertension Symptoms and Measurement Readings of Blood Pressure with Non-Invasive Positive Pressure Ventilation in Hypertensive Patients having Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)

Original Article

Article Type: Original Article | First Published: August 04, 2022

Hypertension is a common comorbidity in obstructive sleep apnea/hypopnea syndrome (OSAHS). OSAHS can raise blood pressures to pre-hypertensive and hypertensive ranges, increase the prevalence of “nondipping” overnight blood pressure patterns, and increase the risk of resistant hypertension. The gold standard treatment for OSAHS is non-invasive ventilation through CPAP...

 Open Access DOI:10.23937/2378-2951/1410262

Atrial Flow Regulator: A New Player for the Treatment of Refractory Heart Failure

Vincenzo Rizza, MD, Giuseppe Uccello, MD, Francesco Federico, MD, Mariano Pellicano, MD, PhD, Maurizio Tespili, MD and Alfonso Ielasi, MD

Article Type: Case Report | First Published: July 23, 2022

Described herein the case of a 55-year-old man diagnosed with advanced heart failure. He had a history of ischemic heart disease leading to moderate left ventricular systolic disfunction, symptomatic for effort dyspnoea despite optimal medical therapy. After coronary angiography and right heart catheterization (showing basal pulmonary capillary wedge pressures - PCWP - 20 mmHg), the patient underwent percutaneous inter-atrial shunt therapy (IAST) through the opposition of an Atrial Flow Regulato...

 Open Access DOI:10.23937/2378-2951/1410261

A New Method for Left Ventricular Lead Delivery: A Side Helix Can Overcome the Tortuous Left Lateral Vein of the Coronary Sinus

Makoto Takano, MD, Yukihiro Inamura, Hisao Matsuda, Tomoo Harada and Yoshihiro J Akashi

Article Type: Review Article | First Published: July 20, 2022

Cardiac resynchronization therapy (CRT) has become an established treatment for heart failure patients with conduction disorders and a significantly reduced ejection fraction. Nevertheless, CRT is limited by several complications, many of which are associated with the insertion of the left ventricular (LV) lead. The LV lead should be placed at the most delayed site in the left ventricle....

 Open Access DOI:10.23937/2378-2951/1410260

In-Hospital Cardiac Manifestations of COVID-19 Pneumonia and their Management

Rajkumar Gangappa Nadakinamani, Prashanth Panduranga, Mohammed Aziz Khandekar, James Pallivathukkal and Baher Youssef Hanna

Article Type: Review Article | First Published: July 09, 2022

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 has been declared a pandemic. Broadly, hospitalized COVID-19 pneumonia patients suffer two important cardiac effects. Firstly, when COVID-19 pneumonia affects people with pre-existing cardiovascular disease (CVD), they have worst outcomes compared to those without CVD....

 Open Access DOI:10.23937/2378-2951/1410259

Sudden Cardiac Arrest in Patient with Aortic Stenosis and Preexcitation

Vikas Kalra, MD and Krittapoom Akrawinthawong, MD

Article Type: Case Report | First Published: June 23, 2022

58-year-old male sustained sudden cardiac arrest (SCA) due to ventricular fibrillation (VF) while at work and was resuscitated with shock therapy. He had prior history of coronary artery disease with bypass, preexcitation, pulmonary hypertension, hyperlipidemia, Hodgkin's disease, hypothyroidism and squamous cell carcinoma....

 Open Access DOI:10.23937/2378-2951/1410258

Awareness of Smoking Cessation Aids in Heart Disease Patients at Governmental Hospitals

Hanin Bogari, Raghad Althubaiti, Ghaidaa Garoot and Asmaa Ali

Article Type: Original research article | First Published: June 13, 2022

Over one million people are smoking worldwide and the total numbers is expected to increase each year. Several studies have shown a relation between smoking and heart problems, which highlight special consideration in smoking cessation awareness in heart disease patients with established vascular disease as a secondary prevention....

 Open Access DOI:10.23937/2378-2951/1410257

Recurrent Pericardial Effusion following Diaphragmatic Hernia Repair

Rony Shah, MD, Aakash Patel, MD, James Craig, MD, Hassan Baydoun, MD and Jeffrey Jordan, MD

Article Type: Case report | First Published: June 13, 2022

The pericardial space is defined as the cavity between the visceral and parietal pericardium and it normally contains 10-50 mL of fluid. A pericardial effusion exists when the intrapericardial volume exceeds these limits. Any process that causes inflammation, injury, or decreased lymphatic drainage can cause a pericardial effusion....

 Open Access DOI:10.23937/2378-2951/1410256

The Effects of Intracoronary Nitroglycerine Administration on Lesion Parameters, Intervention Success and 1-Year MACE in Patients with Acute Coronary Syndromes

Hakan Duman, MD, Elif Ergül, MD, Hikmet Hamur, MD and Selami Demirelli

Article Type: Original Article | First Published: June 03, 2022

Nitroglycerine (NTG) was used to relieve ischemic symptoms in patients with coronary artery disease. However, some studies demonstrated the positive effects of NTG on coronary circulation. In addition, NTG has been administrated to evaluate culprit lesion characteristics during coronary angiography....

 Open Access DOI:10.23937/2378-2951/1410255

Acute Management of a Spontaneous Coronary Artery Dissection with a Distal Occlusive Thrombus

Trinava Roy, DO, Jason Naftulin, DO, Keith Brown, DO and Nicholas Roy, DO

Article Type: Case Report | First Published: May 30, 2022

We describe a unique case of a 57-year-old female who presented with chest pain who was found to have a ST segment elevation myocardial infarction (STEMI) on electrocardiogram....

 Open Access DOI:10.23937/2378-2951/1410254

Coronary Artery Ectasia and Oral Anticoagulation: A Case Report

Shivum Desai, BS, Justin Dombrowski, BS and Joseph Klag, DO, FACC, FSCAI

Article Type: Case Report with Brief Literature Review | First Published: April 30, 2022

Coronary Artery Ectasia is a pathology effecting nearly 4.9% of the general population. This disease process can be found in any one of the coronary arteries and often presents in patients with comorbid conditions such as coronary artery atherosclerosis and hypertension. This combination of disease processes is often difficult to treat due to the lack of peer-reviewed data and treatment guidelines for coronary artery aneurysms. Additionally, there is currently no general consensus on the use of ...

 Open Access DOI:10.23937/2378-2951/1410253

Partially Resolving Myocardial Fibrosis Five Months Following the mRNA COVID-19 Vaccine: An MRI Based Case Report

AFM Ashik Imran, DO, MBBS, Won Jun Park, MD and Michael R Sood, MD, MS

Article Type: Case Report | First Published: April 27, 2022

Myocarditis is a disease that has varying degrees of clinical manifestations. Furthermore, its diagnosis and management can pose as a challenge to clinicians. With over 250 million people receiving the mRNA covid vaccine, there have been rare reports of myocarditis, pericarditis or other cardiovascular involvement. However, its natural course remains unclear. We report a 30-year-old healthy male who was hospitalized 3 days after the second dose of the covid-19 vaccination. He had high cardiac la...

 Open Access DOI:10.23937/2378-2951/1410251

STEMI during Cardiocerebral Infarction (CCI): Is it Safe to Perform Primary Percutaneous Coronary Intervention?

Thon Hon Yong, Jia Hao Jason See and Boon Wah Liew

Article Type: Case Series | First Published: April 14, 2022

Emergency percutaneous coronary intervention (PCI) is a critically important reperfusion strategy for myocardial salvage in the event of acute ST elevation myocardial infarction (STEMI). However, it poses great challenges to the treating cardiologist if there is a simultaneous acute cerebral infarction because of potential intracranial complications. Particularly, the use of dual antiplatelet and high dose anticoagulants during PCI has been well documented to increase the risk for cerebral hemor...

 Open Access DOI:10.23937/2378-2951/1410252

Enlarged Left Ventricular Diastolic Dimension does not Predict Irreversible Left Ventricular Systolic Function in Patients with Atrial Arrhythmia

Hisao Matsuda, Yui Nakayama, Airi Noda, Toru Nakanishi, Dan Koto, Mizuho Kasahara, Takayuki Warisawa, Kei Mizukoshi, Makoto Takano, Koichi Mizuno, Akira Kasagawa, Tarou Suchi, Daisuke Togashi, Ikutarou Nakajima, Kenichi Sasaki, Hidekazu Miyazaki, Toshiyuki Furukawa, Tomoo Harada and Yoshihiro J Akashi

Article Type: Original Article | First Published: April 20, 2022

Atrial arrhythmia (AA) and left ventricular systolic dysfunction (LVSD) frequently co-exist, and potentially represent growing public health problems. Determining whether tachycardia is an indicator or consequence of LVSD in patients with tachycardia and LVSD is difficult. Tachycardia-mediated cardiomyopathy (TCM) raises a “chicken or egg” question. Regardless of the etiology, patients with severe LVSD are considered candidates for the implantation of a cardioverter defibrillator as primary ...

 Open Access DOI:10.23937/2378-2951/1410250

Left Atrial Myxoma and Systolic Anterior Motion of the Mitral Valve with Sigmoid Septum complicated by Left Ventricular Outflow Tract Obstruction

Zhenwei Teo, Jian Jing Tan, Chakaramakkil Mathew Jose and Jia Hao Jason See

Article Type: Case Report | First Published: March 30, 2022

Patients with symptomatic systolic anterior motion (SAM) of the anterior mitral valve leaflet and left ventricular outflow tract obstruction (LVOTO) pose significant challenges in their management. This often occurs in a setting of hypertrophic cardiomyopathy (HCM), and occurrence of SAM without HCM is uncommon. In this report, we present a case of anterior mitral valve leaflet SAM with sigmoid septum complicated by LVOT obstruction, as well as a concomitant left atrial myxoma, which was treated...

Volume 9
Issue 2