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International Journal of

Diabetes and Clinical ResearchISSN: 2377-3634

Early Online

 Open Access DOI:10.23937/2377-3634/1410182

Pathophysiology of the Skin in Type 1 and Type 2 Diabetes and Emerging Therapeutic Opportunities

Priyanka Prabhakar Poonja, MBBS, MSc and Flora Kiss, MD, PhD

Article Type: Review Article | First Published: 2024/05/31

Skin manifestations of diabetes mellitus (DM) occur as a result of impaired insulin signalling, insulin resistance and chronic hyperglycemia. The biophysical properties of the outer barrier of the epidermis the stratum corneum (SC), reflect the status of both epidermal function and systemic conditions, with over two-thirds of DM patients known to experience skin involvement....

 Open Access DOI:10.23937/2377-3634/1410184

Prevalence of Major Comorbidities and Associated Factors among Adult Diabetic Patients Attending Diabetic Follow up Clinic at Selected Public Hospitals of Addis Ababa, Ethiopia

Haleluya Girma, Kabtiymer Shiferaw and Mesfin Aklilu

Article Type: Research Article | First Published: 2024/06/05

Data was collected from April 28 to May 29, 2023. 417 study participants from 4 public hospitals were selected with simple random sampling technique. Data was collected by using structured and pretested questionnaire, medical record was used in order to obtain relevant information’s and measurement was done to obtain BMI. Data was analyzed using SPSS version 25. Bivariable and Multivariable binary logistic regression analysis were done to determine the association between the outcome variable ...

 Open Access DOI:10.23937/2377-3634/1410183

The Relationship between HbA1c and Glucose Management Indicator and Time in Range in Youth with Type 1 Diabetes: A Single Centre Study

Sirisha Kusuma Boddu, Xanthippi Tseretopoulou, A. Emile J. Hendriks, Ajay Thankamony and M. Loredana Marcovecchio

Article Type: Original Article | First Published: 2024/05/31

As continuous glucose monitoring (CGM) becomes increasingly utilized, it is relevant to better understand the relationship between CGM metrics and HbA1c. We aimed to assess the concordance between HbA1c and both glucose management indicator (GMI) and time in range (TIR) in youth with type 1 diabetes (T1D)....

 Open Access DOI:10.23937/2377-3634/1410181

Effect of Asparagus africanus (Asparaceae) Aqueous Extract on Renal Complications in High Fat Diet and Streptozotocin-Induced Type 2 Diabetes in Male albino Wistar Rats

Focham Evans Ngwenah, Oumar Mahamat, Bashi Brenda Mugob and Tume Chrsitopher

Article Type: Research Article | First Published: 2024/05/02

Asparagus africanus has been claimed to possess antidiabetic activity in the ethnomedicinal literature. The present study was carried out to investigate the effect of aqueous extract of A. africanus (EAA) in control of renal complications in experimentally-induced type 2 diabetes mellitus in Wistar rats....

 Open Access DOI:10.23937/2377-3634/1410180

Clinical and Sociodermographic Predictors of Poor Quality of Life among Older Type 2 Diabetes Patients Attending the Family Medicine Clinics at a Tertiary Institution in Nigeria

Oluwatuyi EO, Oduniyi OA, Malomo SO, Sodipo OO, Olopade OB, Odunaye-Badmus SO and Odiana RN

Article Type: Original Article | First Published: 2024/01/27

Type 2 Diabetes mellitus is a chronic metabolic disease with significant implications on health status and quality of life (QoL) in terms of physical, social, environmental, and psychological well-being. Old age also has a significant influence on QOL, therefore, the impact of diabetes on the QOL of older persons can be more severe. In managing these older diabetics attention needs to be paid to the clinical and sociodemographic factors that may impact their QOL so that these can be modified whe...

 Open Access DOI:10.23937/2377-3634/1410179

Gestational Diabetes: Is the Trimester of Diagnosis Determinant on Maternal and Fetal Outcomes?

Fernanda Alves, Ana Margarida Balsa, José Eira, Ana Moreira and Osvaldo Moutinho

Article Type: Original Article | First Published: 2024/01/13

Data were collected on pregnant women with singleton pregnancies whose birth occurred at our center between January 2021 and May 2023. The sample was divided into two groups, according to the trimester of diagnosis of gestational diabetes, which were compared with respect to several variables....

 Open Access DOI:10.23937/2377-3634/1410177

Anti-oxidative, Anti-inflammatory and Anti-apoptotic Efficacy of Anacardium occidentale Nuts Methanolic Extract in Pancreas of High-Fat Diet/Streptozotocin-Induced Diabetic Rats

Folasade Omobolanle Ajao, Marcus Olaoye Iyedupe, Oluwatosin Akanmu, Noheem Olaolu Kalejaiye, Ayobami Lydia Adegoke and Luqmon Adekunle Adeniji

Article Type: Research Article | First Published: 2023/12/22

Adverse complication of anti-diabetic drugs demand for alternative novel therapy. This study investigated efficacy of Anacardium occidentale nut methanolic extract on oxidative stress, inflammation and apoptosis in pancreas of HFD/streptozotocin (STZ)-induced diabetic rats....

 Open Access DOI:10.23937/2377-3634/1410175

Impact of Social Determinants of Health on Charcot Neuroarthropathy: A Retrospective Chart Review

Kelly M Dopke, BS, Mahad Muhammad, Nicole Fye, BS, Andrea Shehaj, BS, Kirsten Mansfield, BA, MPH, Shelby Alwine, BS, Kaitlin Saloky, MD, Christopher Stauch, MD, Sohrab Vatsia, MD, Erdi Ozdemir, MD and Michael Aynardi, MD

Article Type: Brief Report | First Published: 2023/12/02

Charcot neuroarthropathy (CN) is a destructive condition, commonly affecting the foot, and manifests secondary to diabetes mellitus. We compare basic demographics and investigate trends among patients with CN treated at a large, quaternary academic medical center according to surgical procedure, attendance at physical therapy (PT), and all-cause mortality....

 Open Access DOI:10.23937/2377-3634/1410174

Insulin Injection Abscesses caused by Bacteria of the Burkholderia cepacia Complex

Md Ejaz Alam, Mohammad Hayat Ahmad Bhat, Shoiab M Patto and Mohammad Afaan Bhat

Article Type: Case Report | First Published: 2023/11/04

Burkholderia cepacia complex (BCC) consists of more than 20 distinct gram-negative bacterial species. While commonly associated with cystic fibrosis (CF), BCC infections are not frequently reported in individuals with diabetes mellitus (DM). In this case report a 70-year-old female with multiple comorbidities, including Type 2 Diabetes Mellitus (DM), Chronic Kidney Disease (CKD), and Hypertension (HTN), who presented with a Burkholderia cepacia skin abscess at an insulin injection site on her an...

 Open Access DOI:10.23937/2377-3634/1410167

Remission of Type 2 Diabetes with High-Fiber, Low-Fat, and Calorie Restricted Plant-Based Diet Study

Gunadhar Panigrahi, MD, FACC, DipABLM

Article Type: Clinical Research | First Published: March 11, 2023

Type 2 Diabetes (T2D) is a chronic progressive disease, and its prevalence is on the rise around the world. Despite advances in pharmacotherapy, mitigating the burden of the disease on individuals, societies and the healthcare system remains a challenge. Remission has emerged as a therapeutic target in T2D with wide range of interventions. A plant-based diet seems to be promising to achieve this goal. The present study is conducted to establish the feasibility of achieving remission of type 2 di...

 Open Access DOI:10.23937/2377-3634/1410166

High Rate of Mortality in Children and Youth with HIV Infection Compared to those with Diabetes in Tanzania

Edna S Majaliwa MD, MMED, FESPE, Joel Ndayongeje BSC, MSC MPh, Kaushik Ramaiya MBBS, MMED, Blandina T Mmbaga MD, MMED, PhD and Sayoki G Mfinanga MD, PhD

Article Type: Original Article | First Published: March 11, 2023

Pediatric and youth diabetes mellitus (DM) and pediatric and youth human immunodeficiency virus (HIV) infection are among the chronic diseases with significant public health implications and high mortality. The availability of mortality statistics in type 1 diabetes and HIV/AIDS is critical for addressing the two conditions in one setting. To compare the mortality of children and youth living with Diabetes (CYLDM) versus children and youth living with HIV (CYLHIV)....

 Open Access DOI:10.23937/2377-3634/1410165

A Randomized, Double-Blind, Monocentric, and Placebo- Controlled Blood Glycemic Response Evaluation of Sweetch, a Natural Sugar Replacement Blend, on Healthy Volunteers

Le A Minh, Do A Tu and Khaiat Alain, PhD

Article Type: Clinical Study | First Published: January 25, 2023

Diabetes mellitus is a serious global concern due to its long-term health-related effects and the financial burden it poses to healthcare systems and families around the world. Excess consumption of sugar is one of the main causes of the issue. There are many sweetening ingredients that claim to be the solution to substitute normal sugar while maintaining the blood sugar level at a low level, yet the evidence is lacking and not always substantiated....

 Open Access DOI:10.23937/2377-3634/1410164

Utilization of Continuous Glucose Monitors in a Group Medical Visit Setting

Laura A. Buchanan, MD, Matthew W. Calkins, MD, Charlotte T. Boyd, MA, Erin M. Saner, MD, Carmen G. Strickland, MD, John G, Spangler, MD and Julienne K. Kirk, PharmD*

Article Type: Brief Report | First Published: December 29, 2022

The aim of this study is to assess the utilization of CGMs in a GMV setting to improve patient activation and engagement, quality of life, and metabolic outcomes including glycemic control through modified lifestyle behaviors in patients with Type 2 diabetes. Group medical visits (GMV) are an evidence- based care model shown to improve outcomes in diabetes. Monitoring tools that readily demonstrate cause-and-effect relationships between recommended lifestyle interventions and optimal glycemic c...

 Open Access DOI:10.23937/2377-3634/1410163

Diabetes and Driving - Significant Deficits in Knowledge and Practice

IN Khan, F Capatana, LD Premawardhana and MA Adlan

Article Type: Research Article | First Published: December 22, 2022

Motor vehicle drivers who are diabetic and health care professionals who care for them, lack awareness of regulations pertaining to safe driving. We aim to assess their knowledge, practice, and adherence to recommendations in this study of diabetics who drive while taking hypoglycaemic agents....

 Open Access DOI:10.23937/2377-3634/1410162

Personalized Evidence, and Young Adults’ Attitude and Behaviour Towards Type 2 Diabetes Mellitus Preventive Lifestyle Measures

Rabi Ilemona Ekore, John Oselenbalu Ekore and Hany Ramadan

Article Type: Original Research | First Published: December 03, 2022

Behaviour change programmes have demonstrated diabetes risk-reduction benefits. Studies on diabetes preventive lifestyle activities largely focus on middle-aged/older adults. We investigated non-diabetic young adults’ risk of developing Type 2 diabetes mellitus, and their attitudes and behaviours towards preventive lifestyle activities....

 Open Access DOI:10.23937/2377-3634/1410160

Diabetic Complications and Associated Factors among Diabetic Patients in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Melak Gedamu, Camilla Mulusew and Mamo Feyissa Senbeta

Article Type: Original Research | First Published: November 17, 2022

Diabetes mellitus is a rapidly increasing chronic disease associated with complications resulting in long-term damage and failure of various organ systems. In Ethiopia, there is a dearth of evidence on the prevalence of Diabetic complications....

 Open Access DOI:10.23937/2377-3634/1410159

Intelligent Prophylaxis of Diabetic Foot Ulcer

Arthur Grünerbel and Lorenz Grünerbel

Article Type: Clinical Study | First Published: September 30, 2022

A high skin surface pressure at the feet over a longer period of time can cause foot ulcers. It can occur due to insufficient relief of tissue and a lack of alarm signals from the nervous system, especially for patients with Diabetic Polyneuropathia. A healthy person would move and relieve the foot after a while. A medical wearable can warn a patient without natural alarm signals....

 Open Access DOI:10.23937/2377-3634/1410158

What Impact Does Glycemic Control Have on the Final Outcome of Diabetic Patients with Severe COVID-19?

Fadila Salmane, Faïza Charif, Zaynab Mahdi, Rayhana Rahouti, Hafça Lahbib, Aouatif Boucht, Meryem Smouni, Ouassima Bernichi, Mohamed Hannana, Wiam Ftouh, Hicham Sbai, Ismail Labib, Youssef Moutiaa, Adil Najdi and Mariam Benkacem

Article Type: Original Research | First Published: September 30, 2022

Diabetes represents one of the most frequently reported comorbidities in patients with COVID-19 disease; and is a risk factor for disease progression, and death. Assessing the impact of glycemic control on the progression of Covid-19 disease....

 Open Access DOI:10.23937/2377-3634/1410157

Changing the Face of Diabetes

Stanley S Schwartz, MD, FACP, FACE

Article Type: Short Commentary | First Published: May 28, 2022

To be clear, this is not a criticism of current doctrine or those that came before us. In fact, this is a call to recognize that time, knowledge, and understanding marches forward and we should not be too slow to appreciate this fact....

 Open Access DOI:10.23937/2377-3634/1410156

Skin Barrier Changes in T1DM and T2DM

Priyanka Prabhakar Poonja, MBBS, MSc

Article Type: Review Article | First Published: April 15, 2022

Cutaneous manifestations of diabetes mellitus (DM) are a group of skin disorders that characteristically arise from prolonged chronic hyperglycemia and impaired insulin signaling or insulin resistance. There are several skin diabetic pathologies associated with the two main types of diabetestype 1 (T1DM) and type 2 diabetes (T2DM), which tend to negatively impact the patients quality of life. The literature reveals variations in the skin barrier changes between the two DM types, and this may pro...

Volume 9
Issue 2