International Journal of Medical Nano Research is an open access peer reviewed journal that publishes latest discoveries in wide variety of medical and clinical improvements in the nano research. Nano medical research, an invading technology from the mixture of biomedical and clinical science which has shown great impact in creating structures, systems and devices of length ranging from 1-1000 nanometers. Detailed picture of molecules and events which takes place in a disease can be easily find out by nano science and also used to discovery, develop and testing of novel medicine. This science have already been used in clinical which have good impact for drug development, with increase in demand of nano science many national cancer institute's are attracted towards the nano research for diagnosis, detecting and also treatment for the various cancers. Advancing of the nano science have built a nano sensors which have been used for detecting the biochemical and genetic measurements in living, which make easy to screen the disease and also makes easy for drug discovery.
The main focus of this journal is to publish the recent research in the medical nano technology and also allows for easy access of the articles globally and also various opinions of authors, researchers and doctors for the users online. This journal publishes all types of article like research, review, commentaries and many more. We mainly strengthen and request the authors to submit the results with the clear and detailed explanation to follow by the rigorous review process.
Articles Search by Keyword | Journal title | Author name | DOI
Open Access DOI:10.23937/2378-3664.1410030
Gareth R Williams, Timothy J Prior, Geoffrey Hayes, Barry L Chuckle, and Chas N Dave
Article Type: Short Communication | First Published: August 26, 2019
Spastic colon injure tangible introduces viscoelastic jumpy moist introduces value overconfident tangible value introduces tame; tame tangible overconfident efficacy tame tangible curtail overconfident tangible overconfident injure girth moist island spastic colon. Viscoelastic tangible island and therefore spastic colon injure viscoelastic and therefore tame spastic colon moist curtail efficacy island girth introduces spastic colon jumpy in tangible and therefore moist girth viscoelastic tame o...
Open Access DOI:10.23937/2378-3664.1410029
Ekaterina Posokhina, Nikita Ronzhin, Olga Mogilnaya, Alexey Baron and Vladimir Bondar
Article Type: Research Article | First Published: August 14, 2019
A supramolecular indicator system (cellulose-nanodiamonds- urease) for reusable biochemical detection of urea has been fabricated using sequential immobilization of the components. Modified nanodiamonds (MNDs) were covalently immobilized onto DEAE cellulose granules via the nucleophilic addition reaction. At DEAE cellulose: MND ratio of 4:1 (w/w), up to 110 μg of nanoparticles bound onto 1 mg of the polymer during the addition reaction. Urease was immobilized by covalent conjugation onto the po...
Open Access DOI:10.23937/2378-3664.1410028
Maii I Sholqamy, Ehab S Abd-ElHamid, Amr H Mostafa El-Bolok, Aly F Mohamed and Waleed A El-Said
Article Type: Research Article | First Published: July 17, 2019
The change in cell size and alterations in the distribution of cells at different phases of the cell cycle are indicators of change in cell homeostasis. In this study, the HEp-2 cell line cells were treated for 24 hours by two shapes of Gold nanoparticles (GNPs): Gold nanospheres (GNSs) and Gold nanorods (GNRs). The cytotoxic effect of GNPs was evaluated by different methods. The MTT assay revealed that GNPs have a cytotoxic effect on HEp-2 cells and the GNRs are more toxic than GNSs. Image morp...
Open Access DOI:10.23937/2378-3664.1410027
S Huclier-Markai, E Ntsiba, E Thomas, C Alliot, CS Cutler, F Luxc and O Tillement
Article Type: RESEARCH ARTICLE | First Published: February 25, 2019
Diagnostics that combine imaging techniques such as PET and MRI could enhance disease detection and location if effective multimodal contrast agents can be developed. A nanoparticle called AGuIX has been developed that is comprised of gadolinium-bound by chelates and additional free chelates that can be further labelled with radioactive isotopes enabling both PET and MRI imaging. Herein, we describe the size characterization of these nanoparticles together with their size distribution, which is ...
Open Access DOI:10.23937/2378-3664.1410026
Article Type: Review Article | First Published: December 05, 2018
Spray drying plays a crucial role in the processing of pharmaceutical products such as pills, capsules, and tablets as it is used to convert drug-containing liquids into dried powdered forms. Nano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and delivering the drugs to the right place and time in the body. The nano spray dryer developed in the recent years extends the spectrum of produced powder part...
Open Access DOI:10.23937/2378-3664/1410025
Subha Veeramani, Kirubanandan Shanmugam and Renganathan Sahadevan
Article Type: Research Article | First Published: November 22, 2018
Iron oxide nanoparticle is the most promising nanoparticles (NPs) capable in Drug Delivery and targeting. Iron oxide nanoparticles were synthesized by green synthesis. Galactomannan, when attached to the surface of the nanoparticles, increases the biocompatibility of the nanoparticles. Folic acid (FA) is used as the ligand to target folate receptors, which are found abundant in cancer cells. FeNPs-GM-FA could target cancer cells when used as drug carriers. The synthesized iron oxide nanoparticle...
Open Access DOI:10.23937/2378-3664.1410024
Subha Veeramani, Ernest Ravindran RS, Preethi Ramadoss, Cyrril Joseph, Kirubanandan Shanmugam and Renganathan S
Article Type: Research Article | First Published: October 10, 2018
Green synthesis is a novel process for the preparation of numerous metallic nanoparticle and provides a safer and eco-friendly process simultaneously achieving functionalization of nanoparticles with bioactive molecules in the plants extract. Green synthesis of silver nanoparticles (AgNPs) is performed using the aqueous extract of Ipomoea pes-caprae stems which acts as a bio-reducing agent. UV spectroscopic investigation confirms the formation of AgNPs by noticing the peak at 448 nm due to its s...
Open Access DOI:10.23937/2378-3664/1410023
Sandeep Patnaik, Aditya D Kurdekar, LA Avinash Chunduri, C Prathibha and K Venkataramaniah
Article Type: Research Article | First Published: October 08, 2018
Phase solubility behavior, physico-chemical characteristics, cytotoxicity, morphology and dissolution enhancement of Naproxen-PVP Nanoformulations have been studied. Drug-polymer ratios of 1:1, 1:2, 1:3, 1:4 for the poorly water-soluble drug, naproxen and the polymer PVP are prepared via wet milling using a conventional Retsch Planetary ball mill. The highest dissolution enhancement over that of the pure drug, 310% was achieved for the formulation ratio of 1:4. This ability of amphiphilic surfac...
Open Access DOI:10.23937/2378-3664/1410022
Article Type: Research Article | First Published: October 08, 2018
In the current paper, the first step for using Os-Pd/HfC nanocomposites as luminophore in producing Electrochemiluminescence (ECL) biosensor-namely increasing the sensitivity of biosensor through creating Os-Pd/HfC nanocomposites and using it instead of other nanocomposites for detecting and tracking of human gastroenterological cancer cells, tissues and tumors, is evaluated. Further, optimization of tri-n-propylamine (TPrA), 2-(dibutylamino) ethanol (DBAE) and benzyl peroxide (BPO) concentratio...
Open Access DOI:10.23937/2378-3664/1410021
John G Bruno and Taylor Phillips
Article Type: Research Article | First Published: April 30, 2018
DNA aptamers were developed against human growth hormone releasing peptide (GHRP)-6 and the major metabolite of GHRP-2 (pralmorelin) known as AA-3 (D-Ala-D(β-naphthyl)-Ala-Ala-OH) in 10% human serum or 50% human urine. The lead 5'-biotinylated candidate aptamers from ELISA-like microplate screening were conjugated to commercially available Dynal™ streptavidin-polystyrene-coated 2.8 µm diameter magnetic (magnetite) microbeads (MBs) and used to "pull down" and purify or enrich for their cognat...
Open Access DOI:10.23937/2378-3664/1410020
Hassan Maleki, Farid Dorkoosh, Mahdi Adabi, Masood Khosravani, Hossein Arzani and Morteza Kamali
Article Type: Research Article | First Published: November 23, 2017
The purpose of the current study was to prepare Methotrexate (MTX) loaded Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) and investigates their toxicity effect on human glioblastoma cells. The influence of different experimental parameters including polymer concentration....
Open Access DOI:10.23937/2378-3664/1410019
Cesar Alejandro Almonaci Hernandez, Karla Juarez-Moreno, Martin E Castaneda-Juarez, HoracioAlmanza-Reyes, Alexey Pestryakov and Nina Bogdanchikova
Article Type: Case Report | First Published: September 28, 2017
Diabetic foot ulcers are one of the major complications of patients with diabetes mellitus. And, due to their high susceptibility to microbial infections, are the leading cause of hospitalization and amputation of lower limbs. It has been well studied the antimicrobial properties of silver nanoparticles (AgNPs), therefore their use in biomedicine is a trend. ...
Open Access DOI:10.23937/2378-3664/1410018
J Vincent Edwards, Krystal R Fontenot, Nicolette T Prevost, David Haldane, Nicole Pircher, Falk Liebner, Alfred French and Brian D Condon
Article Type: Research Article | First Published: August 19, 2016
The development of point of care diagnostic protease sensors applied to wound healing has received increased interest in chronic wound treatment as an interface for chronic wound dressings. Biosensor technology and the use of nanomaterials have grown exponentially in recent years. A biosensor is fundamentally a biomolecule (functioning as a transducer) attached to a transducer surface, which is activated by a biochemical property that prompts a detection signal specific to a target biomarker. Fo...
Open Access DOI:10.23937/2378-3664/1410017
Abhimanyu Thakur, Mahadi Hasan MA Shahed, Aishwarya Roy and Nabila Sayed
Article Type: Short Commentary | First Published: February 09, 2016
There has been a global interest worldwide in the recent trend of medical researches, which is basically a merge up between basic biology and engineering tools/technology. Imaging, microfluidics, nanofluidics, surface plasmon resonance (SPR) sensor systems, etc. are the widely used engineering tools in medical researches and has given effective clinical results. The most effective and widely used technology amongst these would be nanotechnology which employs methods like nano drug delivery, nano...
Open Access DOI:10.23937/2378-3664/1410016
Reza Tayebee and Abedien Zabardasti
Article Type: Research Article | First Published: February 02, 2016
Borane complexes are extensively studied and have even been the subject of Nobel Prize by Brown . Many scientific data exist that have shown that boron is an essential microelement in animal cells. With the knowledge that borate linkages function in cell-to-cell adhesion, it has been hypothesised that boronates target structural glycoproteins located along the cytoskeletonplasma membrane-cell wall assembly....
Open Access DOI:10.23937/2378-3664/1410015
Derya Ilem-Ozdemir, Evren Gundogdu, Meliha Ekinci and Makbule Asikoglu
Article Type: Review Article | First Published: January 29, 2016
Cancer is a leading cause of death, the second most common cause, exceeded only by heart disease. Still, the current clinical imaging methods and treatments are in many situations unable to provide timely detection and curative therapy. The field of drug delivery stands to be significant advances in nanotechnology and benefits of novel nanotechnology in oncology already starts. New strategies are being designed to deliver chemotherapeutic drugs or imaging agents to the tumor at higher concentrat...
Open Access DOI:10.23937/2378-3664/1410014
Derya Ilem-Ozdemir, Meliha Ekinci, Evren Gundogdu and Makbule Asikoglu
Article Type: Review Article | First Published: January 02, 2016
Radiopharmaceuticals have applications in biologic research, drug discovery, diagnosis of human disease and molecular therapeutics for a wide variety of medical conditions. With the increasingly central role of radiotracers for non-invasive imaging of animal models and human research, small animal imaging centers are likely to have a growing interest in development of radiopharmaceutical science. Although animal experiments are giving the most valuable information about the drug behavior in the ...
Open Access DOI:10.23937/2378-3664/1410013
Santhana Raj L, Paramsavaran S, Koay BT, Izan Shahrina A and Siti Aminah N
Article Type: Review Article | First Published: January 02, 2016
A uranyl acetate replacement staining protocol has eliminated the need for highly toxic uranyl acetate in the electron microscopy laboratory. However, the method is results in undesirable charging effects when viewed under the transmission electron microscope and can be further improved. A modification of the uranyl acetate replacement staining protocol that simplifies the process is described. The modified method takes less time, and produces better contrast and less charging effects compared t...
Open Access DOI:10.23937/2378-3664/1410012
V Tamara Perchyonok, John Souza, Shengmiao Zhang, Desigar Moodley and Sias Grobler
Article Type: Research Article | First Published: November 02, 2015
The bio-active modified polymethyl methacrylate denture resins (PMMA) were prepared by dispersion of the corresponding component in glycerol and acetic acid with the addition of chitosan gelling agent. The release behaviors at physiological pH and also under acidic conditions and stability of the antioxidant-chitosan were also evaluated. Mechanical performance such as tensile strength and compressive strength were measured as well bio-adhesive studies were investigated in order to assess the sui...
Open Access DOI:10.23937/2378-3664/1410011
Koji Kawamura, Ai Matsumoto and Takashi Murashima
Article Type: Research Article | First Published: September 21, 2015
A novel, facile DNA detection method based on aggregation/disaggregation of an AIE (aggregation induced emission) dye-labeled peptide nucleic acid (PNA) probe was developed. This PNA probe plays the role of both target recognition and signal emission, thus it can quantify the target DNA without requiring additives such as intercalators and can distinguish the target from other sequences....
Open Access DOI:10.23937/2378-3664/1410010
Preethi GU, Manu M Joseph, Unnikrishnan BS, Shiji R and Sreelekha TT
Article Type: Review Article | First Published: September 17, 2015
Nanotechnology is one of the most popular branches of science in the current decade where nanofiber scaffolds (NS) attain principal attraction. NS are composed of several nanometer to micrometer diameter fibers similar in nature to collagen, keratin and elastin fibers of the extracellular matrix (ECM) and helps in cell attachment, proliferation and differentiation. NS with desired features can be fabricated using various chemical, physical and biological methods such as electrospinning, phase se...
Open Access DOI:10.23937/2378-3664/1410009
Yen-Wei Chen, Jeanie L. Drury, Whasun Oh Chung, David T. Hobbs and John C. Wataha
Article Type: Review Article | First Published: June 13, 2015
Metal ions are notorious environmental contaminants, some causing toxicity at exquisitely low (ppm-level) concentrations. Yet, the redox properties of metal ions make them attractive candidates for bio-therapeutics. Titanates are insoluble particulate compounds of titanium and oxygen with crystalline surfaces that bind metal ions; these compounds offer a means to scavenge metal ions in environmental contexts or deliver them in therapeutic contexts while limiting systemic exposure and toxicity. I...
Open Access DOI:10.23937/2378-3664/1410008
Ze-Zhi Wu and William S. Kisaalita
Article Type: Editorial | First Published: April 06, 2015
It is a great challenge to simultaneously engineer the three MEFs in a single effort to create physiologically relevant cell culture microenvironments. A survey of the literature has shown that in such a scenario some MEFs may not be as important as others....
Open Access DOI:10.23937/2378-3664/1410007
Cesare Achilli, Stefania Grandi, Annarita Ciana and Giampaolo Minetti
Article Type: Commentary | First Published: January 22, 2015
We have recently had the chance to read the editorial 'Boron Neutron Capture Therapy of cancer as a part of modern nanomedicine', by Alexander V. Safronov, in which the potential of nanomaterials as boron-carriers for the treatment of many types of tumors by BNCT is discusses. The author argues that "Most of the modern papers on BNCT report 'potential' BNCT agents [...] and don't even include cell studies", and "In some cases the abbreviation BNCT may become a 'golden ticket' for authors who jus...
Open Access DOI:10.23937/2378-3664/1410006
Rosario Pignatello, Antonio Leonardi and Sarha Cupri
Article Type: Research Article | First Published: December 29, 2014
Within a wider research project aimed at the pre-industrial development of nanotechnology platforms for the treatment of eye diseases, this work exploited the possibility of obtaining solid lipid nanocarriers (SLN) using ingredients and operating conditions that could be compatible with the technological requirements of medical formulations used for ophthalmic therapies and, above all, capable of an easy industrial scale-up....
Open Access DOI:10.23937/2378-3664/1410005
Tessy Lopez Goerne, Mayra Alvarez Lemus, Gustavo Jardon Guadarrama, Paola Ramirez Olivares, Aurora Sanchez Garcia, Daniel Rembao Bojorquez, Ruben Arguero Sanchez and Octavio Novaro Penalosa
Article Type: Research Article | First Published: December 16, 2014
Because of the worldwide increasing incidence of cancer new alternative therapies are needed. The use of nanotechnology for clinical applications is constantly growing. The objective of this work was to evaluate the effect of the administration of platinum inorganic nanoparticles over livers from Wistar rats. In order to reach this goal cellular Hepatocarcinoma was fist induced with N-nitrosodiethylamine (NDEA) and Carbon tetrachloride....
Open Access DOI:10.23937/2378-3664/1410004
Nader Ebrahimi and Ali Mansoori G
Article Type: Research Article | First Published: November 28, 2014
The primary focus of the nanotechnology therapeutic approaches has been on early disease detection, drug discovery and monitoring, controlled release of therapeutic agents, and targeted drug delivery. Targeted drug delivery system requires more research including statistical modelling to establish the reliability in success of drug targeting. This part of every nanotechnology therapeutic approach is especially fundamental for reaching stronger therapeutic effects with lower side effects....
Open Access DOI:10.23937/2378-3664/1410003
Reshma S Cherian and Mohanan PV
Article Type: Review Article | First Published: October 27, 2014
Graphene, a discrete class of nanomaterial, has come into the limelight after its discovery in 2004. Its unique physico-chemical characteristics like electrical, optical, thermal properties and high mechanical strength has piqued the curiosity of the scientific community worldwide. These properties have been utilized for innovative and novel applications in the field of nanoelectronics and biomedicine. The review focuses on the opportunities and prospects of graphene in biomedical field mainly d...
Open Access DOI:10.23937/2378-3664/1410002
Sahar Mohamed Kamal
Article Type: Research Article | First Published: October 13, 2014
Background: Vildagliptin is one of the Dipeptidyl Peptidase-4 (DPP-4) inhibitors. It is used as a novel oral anti-diabetic drug for the treatment of Type 2 Diabetes Mellitus (T2DM) with significant control of glycated hemoglobin and a lower incidence of hypoglycemia or weight gain. Aim: The present study hypothesized that the DPP-4 inhibitor vildagliptin may exert protective effects on liver in Non-Alcoholic Fatty Liver Disease (NAFLD) in cholesterol-fed albino mice. Methods: Thirty six albi...
Open Access DOI:10.23937/2378-3664/1410001
Alexander V. Safronov
Article Type: Editorial | First Published: August 16, 2014
Boron neutron capture therapy (BNCT) is a method of cancer therapy with a simple idea behind it. Positioning a certain amount of 10B-enriched boron-containing compounds into tumor cells with subsequent irradiation of the tumor tissue by thermal or epithermal neutrons causes tumor damage and death. The mechanism of the tumor cell damage during BNCT is based on the capture-fission reaction between the boron-10 nucleus and a neutron resulting in an α-particle release inside the cell. A success...
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