International Journal of Medical Nano Research is an open access peer reviewed journal that publishes latest discoveries in wide variety of medical and clinical improvements in the nano research. Nano medical research, an invading technology from the mixture of biomedical and clinical science which has shown great impact in creating structures, systems and devices of length ranging from 1-1000 nanometers. Detailed picture of molecules and events which takes place in a disease can be easily find out by nano science and also used to discovery, develop and testing of novel medicine. This science have already been used in clinical which have good impact for drug development, with increase in demand of nano science many national cancer institute's are attracted towards the nano research for diagnosis, detecting and also treatment for the various cancers. Advancing of the nano science have built a nano sensors which have been used for detecting the biochemical and genetic measurements in living, which make easy to screen the disease and also makes easy for drug discovery.

The main focus of this journal is to publish the recent research in the medical nano technology and also allows for easy access of the articles globally and also various opinions of authors, researchers and doctors for the users online. This journal publishes all types of article like research, review, commentaries and many more. We mainly strengthen and request the authors to submit the results with the clear and detailed explanation to follow by the rigorous review process.

 
Journal Information

Title: International Journal of Medical Nano Research

ISSN: 2378-3664

Editor-in-chief: Giuseppe De Rosa

NLM title abbreviation: Int J Med Nano Res

ISO abbreviation: Int J Med Nano Res

Other titles: IJMNR

Category: Nanomedicine

Country of publication: USA

Language: English

DOI: 10.23937/2378-3664

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication type(s): Periodicals

Publisher: ClinMed International Library

Contact email: contact@clinmedjournals.org

 
Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 

 Open Access DOI:10.23937/2378-3664/1410021

Aptamer-Conjugated Magnetic Bead Pull Down and Detection of Human Growth Hormone Releasing Peptides from Serum and Urine by Mass Spectrometry

John G Bruno and Taylor Phillips

Article Type: Research Article | First Published: April 30, 2018

DNA aptamers were developed against human growth hormone releasing peptide (GHRP)-6 and the major metabolite of GHRP-2 (pralmorelin) known as AA-3 (D-Ala-D(β-naphthyl)-Ala-Ala-OH) in 10% human serum or 50% human urine. The lead 5'-biotinylated candidate aptamers from ELISA-like microplate screening were conjugated to commercially available Dynal™ streptavidin-polystyrene-coated 2.8 µm diameter magnetic (magnetite) microbeads (MBs) and used to...
 

 Open Access DOI:10.23937/2378-3664/1410020

Methotrexate-Loaded PLGA Nanoparticles: Preparation, Characterization and their Cytotoxicity Effect on Human Glioblastoma U87MG Cells

Hassan Maleki, Farid Dorkoosh, Mahdi Adabi, Masood Khosravani, Hossein Arzani and Morteza Kamali

Article Type: Research Article | First Published: November 23, 2017

The purpose of the current study was to prepare Methotrexate (MTX) loaded Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) and investigates their toxicity effect on human glioblastoma cells. The influence of different experimental parameters including polymer concentration....
 

 Open Access DOI:10.23937/2378-3664/1410019

Silver Nanoparticles for the Rapid Healing of Diabetic Foot Ulcers

Cesar Alejandro Almonaci Hernandez, Karla Juarez-Moreno, Martin E Castaneda-Juarez, HoracioAlmanza-Reyes, Alexey Pestryakov and Nina Bogdanchikova

Article Type: Case Report | First Published: September 28, 2017

Diabetic foot ulcers are one of the major complications of patients with diabetes mellitus. And, due to their high susceptibility to microbial infections, are the leading cause of hospitalization and amputation of lower limbs. It has been well studied the antimicrobial properties of silver nanoparticles (AgNPs), therefore their use in biomedicine is a trend. ...
 

 Open Access DOI:10.23937/2378-3664/1410018

Protease Biosensors Based on Peptide-Nanocellulose Conjugates: From Molecular Design to Dressing Interface

J Vincent Edwards, Krystal R Fontenot, Nicolette T Prevost, David Haldane, Nicole Pircher, Falk Liebner, Alfred French and Brian D Condon

Article Type: Research Article | First Published: August 19, 2016

The development of point of care diagnostic protease sensors applied to wound healing has received increased interest in chronic wound treatment as an interface for chronic wound dressings. Biosensor technology and the use of nanomaterials have grown exponentially in recent years. A biosensor is fundamentally a biomolecule (functioning as a transducer) attached to a transducer surface, which is activated by a biochemical property that prompts a d...
 

 Open Access DOI:10.23937/2378-3664/1410017

Ovarian Cancer Treatment by Suicide Gene Therapy: Beauty of Nanotechnology in Medicine

Abhimanyu Thakur, Mahadi Hasan MA Shahed, Aishwarya Roy and Nabila Sayed

Article Type: Short Commentary | First Published: February 09, 2016

There has been a global interest worldwide in the recent trend of medical researches, which is basically a merge up between basic biology and engineering tools/technology. Imaging, microfluidics, nanofluidics, surface plasmon resonance (SPR) sensor systems, etc. are the widely used engineering tools in medical researches and has given effective clinical results. The most effective and widely used technology amongst these would be nanotechnology w...
 

 Open Access DOI:10.23937/2378-3664/1410016

Studying Complex Interaction of B2H4 with HOR(R = H, CH3) and Nhn(CH3)3-N (N = 0-3) Molecules

Reza Tayebee and Abedien Zabardasti

Article Type: Research Article | First Published: February 02, 2016

Borane complexes are extensively studied and have even been the subject of Nobel Prize by Brown [1]. Many scientific data exist that have shown that boron is an essential microelement in animal cells. With the knowledge that borate linkages function in cell-to-cell adhesion, it has been hypothesised that boronates target structural glycoproteins located along the cytoskeletonplasma membrane-cell wall assembly....
 

 Open Access DOI:10.23937/2378-3664/1410015

Nanoparticles: From Diagnosis to Therapy

Derya Ilem-Ozdemir, Evren Gundogdu, Meliha Ekinci and Makbule Asikoglu

Article Type: Review Article | First Published: January 29, 2016

Cancer is a leading cause of death, the second most common cause, exceeded only by heart disease. Still, the current clinical imaging methods and treatments are in many situations unable to provide timely detection and curative therapy. The field of drug delivery stands to be significant advances in nanotechnology and benefits of novel nanotechnology in oncology already starts. New strategies are being designed to deliver chemotherapeutic drugs o...
 

 Open Access DOI:10.23937/2378-3664/1410014

Estimating Binding Capability of Radiopharmaceuticals by Cell Culture Studies

Derya Ilem-Ozdemir, Meliha Ekinci, Evren Gundogdu and Makbule Asikoglu

Article Type: Review Article | First Published: January 02, 2016

Radiopharmaceuticals have applications in biologic research, drug discovery, diagnosis of human disease and molecular therapeutics for a wide variety of medical conditions. With the increasingly central role of radiotracers for non-invasive imaging of animal models and human research, small animal imaging centers are likely to have a growing interest in development of radiopharmaceutical science. Although animal experiments are giving the most va...
 

 Open Access DOI:10.23937/2378-3664/1410013

Modification of the Uranyl Acetate Replacement Staining Protocol for Transmission Electron Microscopy

Santhana Raj L, Paramsavaran S, Koay BT, Izan Shahrina A and Siti Aminah N

Article Type: Review Article | First Published: January 02, 2016

A uranyl acetate replacement staining protocol has eliminated the need for highly toxic uranyl acetate in the electron microscopy laboratory. However, the method is results in undesirable charging effects when viewed under the transmission electron microscope and can be further improved. A modification of the uranyl acetate replacement staining protocol that simplifies the process is described. The modified method takes less time, and produces be...
 

 Open Access DOI:10.23937/2378-3664/1410012

Bio-Active Designer Materials and Dentures: from Design to Application

V Tamara Perchyonok, John Souza, Shengmiao Zhang, Desigar Moodley and Sias Grobler

Article Type: Research Article | First Published: November 02, 2015

The bio-active modified polymethyl methacrylate denture resins (PMMA) were prepared by dispersion of the corresponding component in glycerol and acetic acid with the addition of chitosan gelling agent. The release behaviors at physiological pH and also under acidic conditions and stability of the antioxidant-chitosan were also evaluated. Mechanical performance such as tensile strength and compressive strength were measured as well bio-adhesive st...
 

 Open Access DOI:10.23937/2378-3664/1410011

Facile DNA Detection Based on Fluorescence Switching of A Hydrophobic AIE Dye-Labeled Peptide Nucleic Acid Probe by Aggregation/Disaggregation

Koji Kawamura, Ai Matsumoto and Takashi Murashima

Article Type: Research Article | First Published: September 21, 2015

A novel, facile DNA detection method based on aggregation/disaggregation of an AIE (aggregation induced emission) dye-labeled peptide nucleic acid (PNA) probe was developed. This PNA probe plays the role of both target recognition and signal emission, thus it can quantify the target DNA without requiring additives such as intercalators and can distinguish the target from other sequences....
 

 Open Access DOI:10.23937/2378-3664/1410010

Biomedical Applications of Natural Polymer Based Nanofibrous Scaffolds

Preethi GU, Manu M Joseph, Unnikrishnan BS, Shiji R and Sreelekha TT

Article Type: Review Article | First Published: September 17, 2015

Nanotechnology is one of the most popular branches of science in the current decade where nanofiber scaffolds (NS) attain principal attraction. NS are composed of several nanometer to micrometer diameter fibers similar in nature to collagen, keratin and elastin fibers of the extracellular matrix (ECM) and helps in cell attachment, proliferation and differentiation. NS with desired features can be fabricated using various chemical, physical and bi...
 

 Open Access DOI:10.23937/2378-3664/1410009

Titanates and Titanate-Metal Compounds in Biological Contexts

Yen-Wei Chen, Jeanie L. Drury, Whasun Oh Chung, David T. Hobbs and John C. Wataha

Article Type: Review Article | First Published: June 13, 2015

Metal ions are notorious environmental contaminants, some causing toxicity at exquisitely low (ppm-level) concentrations. Yet, the redox properties of metal ions make them attractive candidates for bio-therapeutics. Titanates are insoluble particulate compounds of titanium and oxygen with crystalline surfaces that bind metal ions; these compounds offer a means to scavenge metal ions in environmental contexts or deliver them in therapeutic context...
 

 Open Access DOI:10.23937/2378-3664/1410008

Micro and Nanofabrication: Is a Practical Three-Dimensional Cell Culture Platform for Drug Discovery Achievable?

Ze-Zhi Wu and William S. Kisaalita

Article Type: Editorial | First Published: April 06, 2015

It is a great challenge to simultaneously engineer the three MEFs in a single effort to create physiologically relevant cell culture microenvironments. A survey of the literature has shown that in such a scenario some MEFs may not be as important as others....
 

 Open Access DOI:10.23937/2378-3664/1410007

Bnct and Nanoparticles: A Long Way to a Routine Clinical Method

Cesare Achilli, Stefania Grandi, Annarita Ciana and Giampaolo Minetti

Article Type: Commentary | First Published: January 22, 2015

We have recently had the chance to read the editorial 'Boron Neutron Capture Therapy of cancer as a part of modern nanomedicine', by Alexander V. Safronov, in which the potential of nanomaterials as boron-carriers for the treatment of many types of tumors by BNCT is discusses. The author argues that "Most of the modern papers on BNCT report 'potential' BNCT agents [...] and don't even include cell studies", and "In some cases the abbreviation BNC...
 

 Open Access DOI:10.23937/2378-3664/1410006

Optimization and Validation of a New Method for the Production of Lipid Nanoparticles for Ophthalmic Application

Rosario Pignatello, Antonio Leonardi and Sarha Cupri

Article Type: Research Article | First Published: December 29, 2014

Within a wider research project aimed at the pre-industrial development of nanotechnology platforms for the treatment of eye diseases, this work exploited the possibility of obtaining solid lipid nanocarriers (SLN) using ingredients and operating conditions that could be compatible with the technological requirements of medical formulations used for ophthalmic therapies and, above all, capable of an easy industrial scale-up....
 

 Open Access DOI:10.23937/2378-3664/1410005

Development of A Cellular Hepatocarcinoma Animal Model for the Evaluation of Pt(Acac)2/Tio2 Nanoparticles Effect

Tessy Lopez Goerne, Mayra Alvarez Lemus, Gustavo Jardon Guadarrama, Paola Ramirez Olivares, Aurora Sanchez Garcia, Daniel Rembao Bojorquez, Ruben Arguero Sanchez and Octavio Novaro Penalosa

Article Type: Research Article | First Published: December 16, 2014

Because of the worldwide increasing incidence of cancer new alternative therapies are needed. The use of nanotechnology for clinical applications is constantly growing. The objective of this work was to evaluate the effect of the administration of platinum inorganic nanoparticles over livers from Wistar rats. In order to reach this goal cellular Hepatocarcinoma was fist induced with N-nitrosodiethylamine (NDEA) and Carbon tetrachloride....
 

 Open Access DOI:10.23937/2378-3664/1410004

Reliability for Drug Targeting In Cancer Treatment through Nanotechnology (A Psychometric Approach)

Nader Ebrahimi and Ali Mansoori G

Article Type: Research Article | First Published: November 28, 2014

The primary focus of the nanotechnology therapeutic approaches has been on early disease detection, drug discovery and monitoring, controlled release of therapeutic agents, and targeted drug delivery. Targeted drug delivery system requires more research including statistical modelling to establish the reliability in success of drug targeting. This part of every nanotechnology therapeutic approach is especially fundamental for reaching stronger th...
 

 Open Access DOI:10.23937/2378-3664/1410003

Graphene: A Multifaceted Nanomaterial for Cutting Edge Biomedical Application

Reshma S Cherian and Mohanan PV

Article Type: Review Article | First Published: October 27, 2014

Graphene, a discrete class of nanomaterial, has come into the limelight after its discovery in 2004. Its unique physico-chemical characteristics like electrical, optical, thermal properties and high mechanical strength has piqued the curiosity of the scientific community worldwide. These properties have been utilized for innovative and novel applications in the field of nanoelectronics and biomedicine. The review focuses on the opportunities and ...
 

 Open Access DOI:10.23937/2378-3664/1410002

Anti-Oxidant and Anti-Inflammatory Effects of Vildagliptin in NonAlcoholic Fatty Liver Disease of Mice

Sahar Mohamed Kamal

Article Type: Research Article | First Published: October 13, 2014

Background: Vildagliptin is one of the Dipeptidyl Peptidase-4 (DPP-4) inhibitors. It is used as a novel oral anti-diabetic drug for the treatment of Type 2 Diabetes Mellitus (T2DM) with significant control of glycated hemoglobin and a lower incidence of hypoglycemia or weight gain. Aim: The present study hypothesized that the DPP-4 inhibitor vildagliptin may exert protective effects on liver in Non-Alcoholic Fatty Liver Disease (NAFLD) in chole...
 

 Open Access DOI:10.23937/2378-3664/1410001

Boron Neutron Capture Therapy of Cancer as a Part of Modern Nanomedicine

Alexander V. Safronov

Article Type: Editorial | First Published: August 16, 2014

Boron neutron capture therapy (BNCT) is a method of cancer therapy with a simple idea behind it. Positioning a certain amount of 10B-enriched boron-containing compounds into tumor cells with subsequent irradiation of the tumor tissue by thermal or epithermal neutrons causes tumor damage and death. The mechanism of the tumor cell damage during BNCT is based on the capture-fission reaction between the boron-10 nucleus and a neutron resulting in an ...

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