Special Issue

Title: Etiology Therapy and Pathogenesis of Parkinson's Disease


Handling Editor
Robert Ledeen

Department of Neurology & Neurosciences
Rutgers-The State University of New Jersey
New Jersey Medical School

Short biography

My PhD was in organic chemistry, obtained at Oregon State University, and was followed by postdoctoral studies in chemistry at the University of Chicago, Mt. Sinai, and Albert Einstein College of Medicine. At the latter institution I joined the Department of Neurology to become active in their multidisciplinary studies of gangliosides, first from the standpoint of chemical properties and then more broadly in terms of neurochemical and neurobiological functions. Our contributions to the field have continued in this vein, leading to present emphasis on the role of GM1 ganglioside in Parkinson's disease and autoimmune conditions. I became a tenured professor at Einstein and recently moved my lab to New Jersey Medical School (now part of Rutgers University) to become Director of the Division of Neurochemistry. I felt humbled and honored to find a special issue of Neurochemical Research dedicated in my honor (June, 2012).

Research Interests

(a) Ganglioside biochemistry and biological function in the nervous system.

(b) GM1 ganglioside as mediator of neurotrophic activity in Parkinson's disease.

(c) GM1 ganglioside deficiency as determinant in type 1 diabetes.

(d) metabolic activity of myelin in normal brain and Canavan disease; GM1 ganglioside as mediator of immune cell interactions