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Original Research  |   Volume 3, Issue 2

Coronary Artery Imaging in Patients with Congenital Heart Disease: Improved Image Quality Using an Intravascular Contrast Agent and Specific Magnetic Resonance Sequence Design

Nathalie Dedieu, Dirk Lossnitzer, Marcus R Makowski, Miguel Silva Nodgueira Vieira, Tarique Hussain, James Wong, Reza Razavi, Rene M Botnar and Gerald F Greil
Abstract

In patients with congenital heart disease (CHD) imaging of coronary artery origin and course can be crucial for preoperative planning. A novel intravascular contrast agent Gadofosveset trisodium (GdT) has demonstrated to be superior for angiography due to improved intravascular contrast compared to the currently used extravascular contrast agent Gadopentetate dimeglumine (GdD).

  PDF   |    Full Text | DOI: 10.23937/2378-3656/1410092

Case Report  |   Volume 3, Issue 2

A Case of Macrovascular Complications after Treatment with DPP-4 Inhibitor, Sitagliptin, in a Patient with Type 2 Diabetes Mellitus

Kyuzi Kamoi and Hideo Sasaki
Abstract

Our case involved a 72-year-old woman [height, 1.47 m; body mass index (BMI), 19.9 kg/m2] with T2DM and cardiovascular disturbance. She had been diagnosed with non-obese T2DM (BMI, 20 kg/m2; anti-GAD antibody, negative) during examination for coldness of the lower extremities attributed to cerebral ischemic attack or transient ischemic attack (TIA) in June 2008 (at 65 years old).

  PDF   |    Full Text | DOI: 10.23937/2378-3656/1410093

Case Report  |   Volume 3, Issue 2

Multiple Myeloma and Amyloidosis Presenting as a Restrictive Lung Disease with Respiratory Failure

Marta Pereira, Luis Afonso, Goncalo Fernandes and Rui Araujo
Abstract

Amyloidosis refers to the extracellular tissue deposition of fibrils resulting from abnormal folding of proteins. It may affect multiple organs, causing a broad range of symptoms, thus making the diagnosis particularly challenging. Polyneuropathy is one of the recognized manifestations of Amyloid Light-chain (AL) amyloidosis.

  PDF   |    Full Text | DOI: 10.23937/2378-3656/1410091

Case Report  |   Volume 3, Issue 2

Tetanus: A Case Report following an Upper Extremity Injury

John D. Hill, Eric Wombwell, Jelyn Miller and Gina M. Rochetti
Abstract

Clostridium tetani is a spore-forming, toxin-producing, anaerobic, gram-positive bacillus which enters the CNS causing painful muscle contractions within the host. These painful spasms and stiffness typically manifest initially in the form of trismus, or lockjaw. According to the CDC, tetanus treatment includes the administration of Tetanus Immune Globulin (TIG), a tetanus toxoid booster, agents to control muscle spasms (benzodiazepines), and antibiotics (metronidazole).

  PDF   |    Full Text | DOI: 10.23937/2378-3656/1410090

Case Report  |   Volume 3, Issue 2

Aeroportia - A Rare Finding for a Frequent Disease

Marta Pereira, Luis Miguel Afonso, Sofia Patrao and Rui Araujo
Abstract

A 69-year-old female was admitted to our hospital with complaints of abdominal pain and diarrhea for the last 2 weeks. She was obese, diabetic, and had peripheral arterial disease, but no history of bowel disease or previous gastrointestinal symptoms. Physical examination revealed severe dehydration, hypotension, and diffuse abdominal discomfort. Acute kidney injury with anuria and significant leukocytosis were documented. Furthermore, the patient had severe lactic acidosis.

  PDF   |    Full Text | DOI: 10.23937/2378-3656/1410089

Case Report  |   Volume 3, Issue 2

Stevens - Johnson Syndrome and Intestinal Perforation following regorafenib Administration for Metastatic Rectal Cancer: A Case Report

Tetsuhito Muranaka, Yoshito Komatsu, Kentaro Sawada, Hiroshi Nakatsumi, Yasuyuki Kawamoto, Satoshi Yuki, Riichiro Abe, Kanako C Hatanaka and Naoya Sakamoto
Abstract

Regorafenib monotherapy is useful for the treatment of colorectal cancer (CRC), which is refractory to multiple anti-cancer agents. However, it is associated with a high incidence of adverse events such as hand-foot skin reactions, elevated liver enzymes, etc. Although there are few reports of Stevens-Johnson syndrome (SJS) or intestinal perforation associated with regorafenib, such events should be taken into consideration, as with various other anti-cancer therapies, including bevacizumab.

  PDF   |    Full Text | DOI: 10.23937/2378-3656/1410088