International Archives of

Clinical PharmacologyISSN: 2572-3987


 Open Access DOI:10.23937/2572-3987.1510020

Oncolytic Viruses and Their Application to Cancer Treatment

Xie FZ and Zheng LL

Article Type: Research Article | First Published: August 24, 2019

Early in the 20th Century, a case was reported in The Lancet, that a notable decline in abnormal leucocyte of a female chronic-leukemia suffer was seen, and resulted in her unexpectedly improved condition, after her accidental infection of influenza virus. In 1912, Italian doctor Deface found that tumors of patients with cervical cancer would spontaneously shrink or regress if inoculated attenuated rabies vaccines. And this has raised the curtain on oncolytic virus therapy for tumors. Several mo...

 Open Access DOI:10.23937/2572-3987.1510019

Effect of the Peripheral Trpm8 Ion Channel Activation on the Cardiovascular Parameters

TV Kozyreva, VP Kozaruk and ES Meyta

Article Type: Research Article | First Published: July 06, 2019

The role of TRP ion channels in the physiological processes is far from clear. In this work we studied the effect of the activation of the peripheral TRPM8 ion channel by its agonist menthol on the cardiovascular parameters in normotensive and hypertensive rats when animals were coming out of anesthesia. The role of the TRPM8 ion channel in the regulation of blood pressure was clearly seen in normotensive animals: Activation of this channel by application of 1% menthol (agonist of TRPM8 ion chan...

 Open Access DOI:10.23937/2572-3987.1510018

Incidence of Hypoglycemia in Patients with Renal Dysfunction Treated for Hyperkalemia with Regular Insulin: A Single Center, Retrospective Cohort Study

Dannielle R Brown, PharmD, BCPS, Chase C Brown, Tracie A Delay, Genevieve L Hayes and Ruth C Campbell

Article Type: Research Article | First Published: June 03, 2019

The primary outcome was the incidence of hypoglycemia during the hospitalization after the administration of insulin for hyperkalemia. Key secondary outcomes included incidence of hypoglycemia within 24 hours of insulin administration and identification of risk factors associated with hypoglycemia. Data collected included patient age, sex, race, history of diabetes, stage of CKD, weight, body mass index (BMI), baseline blood glucose, inciting serum potassium concentration, units of regular insul...

Volume 5
Issue 1