Oncolytic Viruses and Their Application to Cancer Treatment
Xie FZ and Zheng LL
Article Type: Research Article | First Published: August 24, 2019
Early in the 20th Century, a case was reported in The Lancet, that a notable decline in abnormal leucocyte of a female chronic-leukemia suffer was seen, and resulted in her unexpectedly improved condition, after her accidental infection of influenza virus. In 1912, Italian doctor Deface found that tumors of patients with cervical cancer would spontaneously shrink or regress if inoculated attenuated rabies vaccines. And this has raised the curtain on oncolytic virus therapy for tumors. Several mo...
Effect of the Peripheral Trpm8 Ion Channel Activation on the Cardiovascular Parameters
TV Kozyreva, VP Kozaruk and ES Meyta
Article Type: Research Article | First Published: July 06, 2019
The role of TRP ion channels in the physiological processes is far from clear. In this work we studied the effect of the activation of the peripheral TRPM8 ion channel by its agonist menthol on the cardiovascular parameters in normotensive and hypertensive rats when animals were coming out of anesthesia. The role of the TRPM8 ion channel in the regulation of blood pressure was clearly seen in normotensive animals: Activation of this channel by application of 1% menthol (agonist of TRPM8 ion chan...
Incidence of Hypoglycemia in Patients with Renal Dysfunction Treated for Hyperkalemia with Regular Insulin: A Single Center, Retrospective Cohort Study
Dannielle R Brown, PharmD, BCPS, Chase C Brown, Tracie A Delay, Genevieve L Hayes and Ruth C Campbell
Article Type: Research Article | First Published: June 03, 2019
The primary outcome was the incidence of hypoglycemia during the hospitalization after the administration of insulin for hyperkalemia. Key secondary outcomes included incidence of hypoglycemia within 24 hours of insulin administration and identification of risk factors associated with hypoglycemia. Data collected included patient age, sex, race, history of diabetes, stage of CKD, weight, body mass index (BMI), baseline blood glucose, inciting serum potassium concentration, units of regular insul...