Severe Acute Respiratory Syndrome - Coronavirus 2 (SARS-CoV-2) is the virus responsible for the pandemic that in the first months of 2020 caused worldwide more than 8 millions of infected subjects and 436,000 deaths. It has been reported that only few individuals affected by cystic fibrosis (CF) developed the clinical manifestations of the often dramatic SARS-CoV-2 related disease, now known as Coronavirus Disease 19 (COVID-19)....

Obstructive sleep apnea (OSA) is an important public health concern with numerous consequences at the societal level, including motor vehicle accidents, increased cardiovascular morbidity, metabolic dysfunction, and behavioral and cognitive deficit. OSA is characterized by a decrease in, or complete cessation of, airflow despite ongoing efforts to breathe, and is related to oxygen desaturation and sleep fragmentation. The prevalence of OSA has been estimated at 14% in men and 5% in women...

Through the application of a strategic framework, the paper attempts to sharpen the focus, coordination and dissemination of promotion of rational use of medicines (PRUM) framework. The purpose of this strategic framework is to guide and organize the systematic planning, implementation, and evaluation of irrational use of medicines and other efforts aimed at improving rational use of medicines and reducing and, ultimately, eliminating irrational use of medicines. The suggested framework efforts ...