Original Research Article | Volume 2, Issue 3
The Effect of Dexmedetomidine and Propofol on Oxidative Stress Parameters during Lower Extremity Surgery: A Prospective Randomized Trial
Safinaz Karabayirli, Ismail Uras, Cemile Koca, Merve Ergin, Ruveyda Irem Demircioglu, Bunyamin Muslu
Tourniquets are routinely applied during lower extremity surgery in order to reduce bleeding during surgery, provide better surgical conditions and consequently to shorten the duration of the operation. However, an inflammatory response is often activated by tourniquet application, leading to prolonged ischemia and reperfusion; consequently, organ damage such as acute lung injury may occur. Muscular ischemia causes hypoxic cellular changes and anaerobic glycolysis, and its neutrophil activation with reperfusion causes the formation of oxygen radicals and the release of vasoactive mediators.
Review Article | Volume 2, Issue 3
Jeppe T Jensen, Peter Vilmann, Lars Konge and Moller
Hospitals and healthcare centers are continuously pushed to deliver a better quality of care with a higher turnover. Hence, there is an increasing demand for shorter procedures and shorter time to discharge. Some of these requirements can be met if sedation is used instead of general anesthesia. Furthermore, sedation, as an alternative to nothing, has its benefits. Two recent studies have shown that sedation for endoscopies increases endoscopist satisfaction, the patient's willingness to undergo a repeat procedure, and the likelihood for successful cecal intubation.
Original Article | Volume 2, Issue 3
The Effects of High-Dose Sugammadex on Erythrocyte Deformability in Rats with Renal Failure Generated by Unilateral Ureteral Obstruction
Fusun Bozkirli, Fikriye Dogrul, Faruk Metin Comu, Hande Arpaci, Omer Bayrak, Mustafa Arslan and Yusuf unal
One of the most common causes of renal insufficiency in children and adults is obstructive nephropathy. Unilateral ureteral obstruction (UUO) is a well-known model to imitate the obstructive nephropathy process in a simple, accelerated and species-independent manner. Previous studies have revealed that morphological lesions in the obstructed kidney are peritubular capillaries rarefaction, tubular atrophy, inflammatory infiltration, widen interstitial space, and progressive tubulointerstitial fibrosis.
Original Research | Volume 2, Issue 3
Ismail Sirit, Ibrahim Ozturk, Dilek Yazicioglu
We aimed to investigate that whether intraoperative intravenous aminophylline is effective for prevention of postdural puncture headache after caesarean section or not. Materials and method: Records of patients who underwent caesarean section between January, 2013 and November, 2013 with spinal anesthesia were examined retrospectively. Patients older than 18 were included in the study. Failed and conversion to general anesthesia was the exclusion criteria.
Commentary | Volume 2, Issue 3
David D. Nguyen, Daneshvari Solanki, Christopher Babl, Nikolaus Gravenstein and Rene Przkora
Pain is a global epidemic and in America is considered the fifth vital sign. It causes significant suffering and disability, and pain contributes to massively increased healthcare costs. Effective pain management is an important outcome and quality measure.