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Case Report Open Access

Speech Disorder and Behavioral Involvement in a Thalamic Stroke: A Case Report

Paola Caruso, Moretti R and Manganotti P
Int J Brain Disord Treat Volume 1, Issue 1

Abstract: Data from literature on clinical manifestation of thalamic strokes have been published for ages. First in 1906 Dejerine e Roussy has spoken about sensory motor disturbances and have opened the door to new pathologic disorders that may occur after thalamic lesions. From 1925 behavior and speech disorders related with thalamic injury were described. Since then a classification of thalamic syndromes into four groups based on the four main arterial territories was accepted. As we know thalamic stroke account for 11% of vertebra basilar infarct. Inferolateral territory infarctions are the most common injury (45%), followed by the paramedian territory infarctions (35%) and the anterior territory lesions (12%), the posterior territory infarctions are less frequent (8%).

PDF   | Full Text   DOI: 10.23937/2469-5866/1510007

Case Report Open Access

Subarachnoid Haemorrhage in Patient with Eosinophilic Granulomatosis with Polyangiitis (Churg and Strauss): A Probable Central Nervous Localisation of Vasculitis

Lescuyer Sylvain, Rondeau-Lutz Murielle, Martinez Camille, Rakotoarivelo Hanta-Nirina and Weber Jean-Christophe
Int J Brain Disord Treat Volume 1, Issue 1

Abstract: We report the case of a 43 year-old patient with Subarachnoid haemorrhage (SAH). He was diagnosed with EGPA because of asthma, naso-sinusal polyposis, asymmetrical peroneal neuritis, general signs, eosinophilic count at 4000/mm3, CRP at 50 mg/l and positive pANCA with anti-MPO specificity at 74 U/ml. Arteriography was normal. He was treated by methylprednisolone and cyclophosphamide. Remission was complete. EGPA is a rare primary vasculitis. Only seventeen cases of central nervous haemorrhages have been reported. EGPA may be revealed by an acute neurologic manifestation as in seven (41%) reported cases.

PDF   | Full Text   DOI: 10.23937/2469-5866/1510006

Case Report Open Access

Guillain-Barre Syndrome with Lymphocytic Pleocytosis of the CSF

Sneha Padidam, Jacqueline Kraft and M Kamran Athar
Int J Brain Disord Treat Volume 1, Issue 1

Abstract: 60-year-old man presented with progressive lower-extremity weakness that progressed to involve respiratory failure and are flexia over several weeks. Electromyography showed both demyelinating and axonal features. Lumbar puncture revealed a lymphocytic pleocytosis. Given the abnormalities on these tests with a clinical picture of Guillain-Barre the patient underwent extensive paraneoplastic testing and full neuro-axis imaging. Imaging revealed abnormal enhancement of ventral and dorsal nerve roots which is consistent with Guillain-Barre.

PDF   | Full Text   DOI: 10.23937/2469-5866/1510005

Research Article Open Access

Cranial Electrotherapy Stimulation (CES) in Neuropsychiatry: Definition & Insights from Electric Learning Paradigms

Naisberg Yakov
Int J Brain Disord Treat Volume 1, Issue 1

Abstract: The main point here is that CES method employ at both practices systematic applications of non-invasive, harmless electric currents in the range of 50 micro-to 2 milliamper, varying from 10 Hz to 100 kHz frequencies. They inject from 10 ms to 250 ms by each scalp pair out of an array of EEG electrodes transporting to regions of interest. Such electromagnetic forces induce equivalent number of ionic oscillatory streams crossing the brain in calibrated coulombs. Optimal control regulates by number of personalize treatment sessions reaching transitory homeostatic resynchronizing (THR) effects in electrical stimulated points limited to any electrode pair respectively.

PDF   | Full Text   DOI: 10.23937/2469-5866/1510004

Case Series Open Access

Benefits of Temporary Intrathecal Baclofen Therapy: Management of Tone and Spasticity

Melissa Ann Eppinger, Thomas J. Sernas and Catherine Anne Mazzola
Int J Brain Disord Treat Volume 1, Issue 1

Abstract: Spasticity and dystonia may develop as a consequence of brain or spinal cord injury (SCI). Central nervous system (CNS) injury may be permanent or temporary, depending on the etiology of brain or spinal cord injury. In anoxic brain injury, there may be transient or reactive demyelination due to cell death or cell dysfunction. If there is ischemia without true infarction, or cell death, there may be some ability of the brain to repair itself or reconstitute the myelination of axons within the white matter of the brain.

PDF   | Full Text   DOI: 10.23937/2469-5866/1510003

Review Article Open Access

MicroRNA in Brain Neoplasia: A Review

Michela Visani, Giorgia Acquaviva, Gianluca Marucci, Moira Ragazzi, Enrico Fraceschi, Alba A Brandes, Giovanni Tallini, Annalisa Pession and Dario de Biase
Int J Brain Disord Treat Volume 1, Issue 1

Abstract: MicroRNAs (miRNAs) are small RNAs involved in regulation of several cellular processes and are involved in the silencing of cell's message in a variety of ways. In cancer, miRNAs can be involved in the regulation of important genes involved in tumorigenesis, tumor development, and angiogenesis. For these reasons, miRNAs could have considered oncogenic-miR (miRNA with oncogenic roles) or oncosuppressor-miR (miRNA with tumor suppressor roles). MiRNAs may alter the expression of genes involved in cell cycle, regulation of cell proliferation, apoptosis, angiogenesis, immune response, tumor invasion and metastasis, and genomic instability of cancer cells.

PDF   | Full Text   DOI: 10.23937/2469-5866/1510002

Case Report Open Access

External Carotid Artery Steal Syndrome via Occipital-Vertebral Anastomosis

Menarvia Nixon, Anil Nanda and Hugo Cuellar-Saenz
Int J Brain Disord Treat Volume 1, Issue 1

Abstract: We describe a case of ECA steal syndrome due to occipital- vertebral anastamosis in an 81 y/o female patient who presented with gait ataxia and dizziness. She was referred to Neuro-interventional Radiology after discovery of carotid bruits on her physical examination. A digital subtraction angiogram confirmed mild internal carotid artery stenosis, however, more concerning was the discovery of retrograde flow of the right vertebral artery with filling of the right external carotid artery via anastomosis with the occipital artery.

PDF   | Full Text   DOI: 10.23937/2469-5866/1510001

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