International Journal of

Blood Research and DisordersISSN: 2469-5696


 Open Access DOI:10.23937/2469-5696/1410014

Pediatric B-cell Non-Hodgkin Lymphoma: 21-year Experience with FAB-LMB Protocols in a Single Institute in Greece

Apostolos Pourtsidis, Marina Servitzoglou, Margarita Baka, Despina Bouhoutsou, Maria Varvoutsi, Dimitrios Doganis, Katherine Strantzia-Michail and Helen Kosmidis

Article Type: Research Article | First Published: May 10, 2015

Aims and background: Our objective was to analyze the clinical and demographic characteristics of children with B-cell lymphoma treated in a single center over the last two decades. Methods: Data was collected by a retrospective review of the charts of all 76 patients treated to our unit, from 1990 to 2010, with FAB LMB 89, 96 protocols and 2003 modifications....

 Open Access DOI:10.23937/2469-5696/1410013

Fetal and Neonatal Alloimmune Thrombocytopenia: Advances in Laboratory Diagnosis and Management

Hacene Brouk and Hanifa Ouelaa

Article Type: Review Article | First Published: April 30, 2015

Fetal and neonatal alloimmune thrombocytopenia (F/NAIT), caused by fetomaternal mismatch for human platelet (PLT) alloantigens (HPAs), is the commonest cause of severe thrombocytopenia in term neonates and is analogous to the fetal/neonatal anaemia caused by haemolytic disease of the newborn (HDN). The most feared complication of this syndrome is the occurrence of intracranial hemorrhage leading to death or neurological sequels....

 Open Access DOI:10.23937/2469-5696/1410012

The Comparison between Microhematocrit and Automated Methods for Hematocrit Determination

Gebrewahd Gebretsadkan, Kebede Tessema, Henock Ambachew and Misganaw Birhaneselassie

Article Type: Research Article | First Published: April 01, 2015

Hematocrit is a test that measures a percentage of blood that is comprised of red blood cell. This is often referred to as packed cell volume (PCV) or erythrocyte volume fraction. It is considered as an integral part of a person's complete blood count, along with hemoglobin concentration, white blood cell count and platelet counts....

 Open Access DOI:10.23937/2469-5696/1410011

Hemolytic Anemia in Alcohol-Induced Liver Disease: A Case Report on Zieve's Syndrome

Shefali Nath and Joshua R Peck

Article Type: Case Report | First Published: March 26, 2015

We report a case of Zieve's syndrome in a patient with a longstanding history of alcohol abuse admitted for acute alcoholic hepatitis. Zieve's syndrome is defied as the triad of hemolytic anemia, hypertriglyceridemia, and jaundice in patients with known liver disease. It is an uncommon diagnosis, but is an important one to consider in patients with known liver disease admitted with these constellation of signs and symptoms....

 Open Access DOI:10.23937/2469-5696/1410010

Lenalidomide in patients with Relapsed or Refractory HTLV-1 Related Adult T cell Leukemia/Lymphoma (ATLL)

Adrienne A. Phillips, Jalanni Giddings, Shing M. Lee and Steven M. Horwitz

Article Type: Case Report | First Published: March 21, 2015

Adult T-cell Leukemia/Lymphoma (ATLL) is resistant to chemotherapy and the acute and lymphomatous subtypes of disease have a dismal prognosis. There is no standard therapy for relapsed or refractory disease in Western countries and new agents are being explored. Lenalidomide is an immunomodulatory agent with promising activity in hematologic malignancies, including non-Hodgkin's lymphoma and represents a novel therapeutic option. ...

 Open Access DOI:10.23937/2469-5696/1410009

The Use of Diffusion Weighted Imaging in the Diagnosis of Intraocular Relapse of Acute Lymphoblastic Leukemia: A Case Report

Kee Kiat Yeo, Jonathan G. Murnick, Marijean M. Miller and Anne L. Angiolillo

Article Type: Case Report | First Published: February 23, 2015

Intraocular relapse of Acute Lymphoblastic Leukemia (ALL) is rare. Prompt diagnosis and treatment can minimize vision loss. We report a case of a young girl diagnosed with pre-B ALL who was initially treated successfully with chemotherapy....

 Open Access DOI:10.23937/2469-5696/1410008

Thrombophilia: Demographics and Clinical Presentation in United Arab Emirates

Fatma H Sajwani and Moza A Khuzam

Article Type: Research Article | First Published: February 20, 2015

Thrombophilia is a group of disorders that increases the patient's risk of thrombosis. Inherited causes of thrombophilia are challenging to diagnose and once diagnosed may subject the patient to prolonged treatment. The extent of the condition is not well established in UAE and data on prevalence and demographics are lacking. This study aimed at setting a baseline data on the prevalence, demographics and clinical presentation of thrombophilia in UAE....

 Open Access DOI:10.23937/2469-5696/1410007

HemoCue versus Complete Blood Count for Hemoglobin Measurement in Adults with Vaso-occlusive Crisis due to Sickle Cell Disease

Michael Bursey, Kane Curtis, Robert Gibson, Hongyan Xu and Matthew Lyon

Article Type: Research Article | First Published: February 17, 2015

Hemoglobin (Hgb) measurement is an important risk-stratification tool for patients presenting to the Emergency Department with vaso-occlusive crisis (VOC) from sickle cell disease (SCD). Point-of- care (POC) Hgb testing such as the HemoCue device decreases time to identification of significant anemia. However, there are no studies evaluating the accuracy of HemoCue testing in patients with SCD and VOC. The purpose of this study was to evaluate the correlation of Hgb measurements from HemoCue com...

 Open Access DOI:10.23937/2469-5696/1410006

The Study of the Mechanism of Action of the Newly Synthesized Direct Anticoagulant of Thiazoline Ammonium -4-Chlorophenyl-2-Hydroxy-4-Oxo-2-Butenoate

Starkova AV, Syropyatov B Ya, Sobin FV and Pulina NA

Article Type: Case Report | First Published: February 08, 2015

The aim of this research is to study the mechanism of action of the newly synthesized substance - Thiazoline Ammonium 4-Chlorophenyl-2-Hydroxy-4-Oxo-2-Butenoate (FS-169), which possesses the direct anticoagulant activity. The research was conducted with the use of 'АPG4-02-P' coagulometer. For the purposes of the study the rabbit plasma was used. The results show that FS-169 effectively changes Partial thromboplastin time and prothrombin time indicators. However, FS-169 has no influence on...

 Open Access DOI:10.23937/2469-5696/1410005

A Case of Localized Neuroblastoma in Caffey Disease, with Early and Uncommon Progression

Manuela Pagano, Chiara Galletto, Maurizio Bianchi and Franca Fagioli

Article Type: Case Report | First Published: January 21, 2015

Background: Caffey disease is a rare syndrome caused by mutation in the alpha-1 collagen type I gene, not described in literature as a predisposing condition to cancer development. Observation: We report a case of a 6-years-old female diagnosed with Caffey disease that developed a localized neuroblastoma. The patient had a poor clinical and radiological response with unusual disease dissemination and progression until death. Conclusion: The case is a rare example of rapid progression of localize...

 Open Access DOI:10.23937/2469-5696/1410004

Diverse Genotype Presentation of the Saudi-Type Poly A Signal Mutation (αTsaudiα) in the Population of Bahrain

Nabeel Al Moamen, Fawzia Mahdi, Ahmed Thabet, Rugaya Abbas, Ebtihal Salman and Ahmed Al Alawi

Article Type: Letter to Editor | First Published: January 15, 2015

A total of 1187 patients with α-thalassemia phenotype presentation have been recruited for this investigation. Preliminary diagnosis of α-thalassemia was based on low hematological indices (MCV and MCH) of the red blood cells and/or persistently low hemoglobin levels, along with low or normal levels of HbA2 and absence of iron deficiency. Th molecular diagnosis of α-thalassemia was established by using a commercially available α-thalassemia strip assay (α-Globin StripAss...

Volume 2
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