Atypical Clinical Picture of Breast Cancer with Dominant Symptoms of Hematologic and Gastrointestinal Malignancies
Malwina Rybicka-Ramos, Grzegorz Kasiarz, Katarzyna Pluta, Tomasz Wilczynski, Jerzy Pruszynski and Ewa Ziolko
Article Type: Case Report | First Published: June 03, 2020
Gastrointestinal malignancy was suspected in a 68-year-old woman with long-term anemia, thrombocytopenia, leukopenia, the presence of fecal occult blood and elevated levels of CEA and CA 19- 9. However, malignancy was not confirmed. The patient was later hospitalized in the Department of Hematology where hematologic disease was excluded. Cervical and inguinal lymphadenopathy and atypical bone marrow cells collected by aspiration biopsy gave rise to the suspicion of bone marrow involvement by tum...
Multicentric Castleman’s Disease with Disseminated Kaposi’s Sarcoma: A Report of Prolonged Misdiagnosis
Xiao Hu, Monika Pilichowska and Cindy Varga
Article Type: Case Report | First Published: June 06, 2020
54-year-old gentleman was diagnosed with acquired immunodeficiency syndrome (AIDS) when presenting with shingles in 2016. He was started on HAART but soon noted a very rapid increase in the size of his cervical, axillary and inguinal lymph nodes, along with profound constitutional symptoms. Immune reconstitution syndrome was suspected and prednisone was tried but did not alleviate symptoms. One month later, a core biopsy of the left axillary lymph node was undertaken and demonstrated predominant...
Heparin-Induced Thrombocytopenia Presenting as Splenic Hemorrhage Following Cardiac Surgery: A Case Report
J Ferry, S Youssef, P WU and L Hegerova
Article Type: Case Report | First Published: May 25, 2020
Heparin induced thrombocytopenia with thrombosis (HIT) is a paradoxical prothrombotic complication of anticoagulant therapy. We report a case of atraumatic splenic hemorrhage due to splenic vein thrombosis as main indicator to diagnosis of HIT. The presentation is reminiscent of the rare bilateral adrenal hemorrhage due to adrenal necrosis that occurs in HIT. Alternative anticoagulation is mainstay of therapy for HIT despite hemorrhage, given the underlying acquired hypercoagulability....
Effects of TSH on Erythrocyte Osmotic Fragility: Signaling Pathway
Evelyn Mendonca-Reis, Camila Cristina Guimaraes Nobre, Artur Paes-Chagas, Leandro Miranda-Alves and Clemilson Berto-Junior
Article Type: Original Article | First Published: March 09, 2020
TSH is a peptide hormone synthetized and secreted by pituitary with fundamental importance for thyroid function. TSH receptors are found in other tissue than thyroid playing diverse roles, including erythrocyte. Based on the fact that deformability is one of the most important features of a mature erythrocyte, we aimed to verify if TSH modulates erythrocytes volume and, if does, which signaling is involved in this modulation. Using hemolysis assay, we create a hemolysis curve of erythrocyte in p...
Analysis of Twelve Cardiovascular Disease Related Gene Mutations among Turkish Patients with Coronary Artery Disease
Gulsah Durmus, Nevin Karakus, Serkan Yuksel and Nurten Kara
Article Type: Research Article | First Published: February 12, 2020
Coronary artery disease (CAD) is a multifactorial disorder. It is important to identify gene mutations that may be responsible for the development of CAD. The aim of this study was to determine the frequency of twelve cardiovascular disease (CVD) related gene mutations in coronary artery patients. The CVD StripAssay (Vienna Lab, Austria) was performed to analyze the twelve gene mutations on 52 coronary artery patients and 39 healthy controls. After DNA isolation from blood samples, hybridization...